Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: May 17, 2024
Abstract
This
study
investigates
the
dynamic
fluctuations
of
pH
caused
by
gastric
acid
secretion,
a
process
both
biological
and
clinical
significance,
with
microrobots.
Abnormal
patterns
acidity
often
indicate
gastrointestinal
diseases,
underlying
importance
precise
intragastric
monitoring.
Traditional
methods
using
fluorescent
probes
face
challenges
due
to
their
faint
solid‐state
fluorescence,
limited
target
specificity,
accuracy.
To
overcome
these
obstacles,
pH‐responsive
organic
microparticles
decorated
magnetite
(Fe
3
O
4
)
nanoparticles
are
engineered.
These
microrobots
exhibit
unique
fluorescence
switching
capability
at
critical
pH,
enabling
monitoring
acidity.
The
magnetic
part
ensures
maneuverability
enable
targeted
navigation.
microrobots’
mechanism
is
elucidated
through
comprehensive
spectroscopy,
microscopy,
X‐ray
diffraction
analyses,
revealing
molecular‐level
structural
transformations
upon
interaction
antacids.
transformations,
specifically
protonation
deprotonation
components,
prompt
distinct
response
correlating
shifts.
In
vitro
ex
vivo
experiments,
simulating
stomach
conditions,
confirm
efficacy
in
imaging.
results
showcase
promising
diagnostic
potential
for
tract
marking
significant
advancement
imaging‐based
medical
diagnostics
locations.
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: July 14, 2023
Early
detection
and
diagnosis
of
many
cancers
is
very
challenging.
Late
stage
a
cancer
always
leads
to
high
mortality
rates.
It
imperative
develop
novel
more
sensitive
effective
therapeutic
methods
for
treatments.
The
development
new
treatments
has
become
crucial
aspect
medical
advancements.
Nanobots,
as
one
the
most
promising
applications
nanomedicines,
are
at
forefront
multidisciplinary
research.
With
progress
nanotechnology,
nanobots
enable
assembly
deployment
functional
molecular/nanosized
machines
increasingly
being
utilized
in
treatment.
In
recent
years,
various
practical
have
transitioned
from
theory
practice,
vitro
experiments
vivo
applications.
this
paper,
we
review
analyze
advancements
treatments,
with
particular
emphasis
on
their
key
fundamental
features
drug
delivery,
tumor
sensing
diagnosis,
targeted
therapy,
minimally
invasive
surgery,
other
comprehensive
At
same
time,
discuss
challenges
potential
research
opportunities
revolutionizing
future,
expected
sophisticated
capable
performing
multiple
functions
tasks,
ultimately
becoming
true
nanosubmarines
bloodstream.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(19)
Published: May 12, 2023
The
recent
rise
of
swarming
microrobotics
offers
great
promise
in
the
revolution
minimally
invasive
embolization
procedure
for
treating
aneurysm.
However,
targeted
treatment
aneurysm
using
microrobots
has
significant
challenges
delivery
capability
and
filling
controllability.
Here,
we
develop
an
interventional
catheterization-integrated
microrobotic
platform
on-demand
physiological
blood
flow.
A
pH-responsive
self-healing
hydrogel
doped
with
magnetic
imaging
agents
is
developed
as
embolic
microgels,
which
enables
long-term
self-adhesion
under
biological
condition
a
controllable
manner.
strategy
initiated
by
catheter-assisted
deployment
followed
application
external
field
aggregation
into
sac
real-time
guidance
ultrasound
fluoroscopy
imaging.
Mild
acidic
stimulus
applied
to
trigger
welding
microgels
satisfactory
bio-/hemocompatibility
physical
stability
realize
complete
embolization.
Our
work
presents
promising
connection
between
design
control
swarms
toward
practical
applications
dynamic
environments.
Micromachines,
Journal Year:
2023,
Volume and Issue:
14(3), P. 668 - 668
Published: March 17, 2023
Nanoscale
fluorescence
emitters
are
efficient
for
measuring
biomolecular
interactions,
but
their
utility
applications
requiring
single-unit
observations
is
constrained
by
the
need
large
numerical
aperture
objectives,
intermittency,
and
poor
photon
collection
efficiency
resulting
from
omnidirectional
emission.
Photonic
crystal
(PC)
structures
hold
promise
to
address
aforementioned
challenges
in
enhancement.
In
this
review,
we
provide
a
broad
overview
of
PCs
explaining
structures,
design
strategies,
fabrication
techniques,
sensing
principles.
Furthermore,
discuss
recent
PC-enhanced
fluorescence-based
biosensors
incorporated
with
emerging
technologies,
including
nucleic
acids
sensing,
protein
detection,
steroid
monitoring.
Finally,
current
associated
an
outlook
enhancement
photonic-plasmonics
coupling
point-of-care
biosensing
as
well
monitoring
analytes
biological
environmental
relevance.
The
review
presents
transdisciplinary
arena
spectroscopy
photo-plasmonics,
life
science
research,
materials
chemistry,
cancer
diagnostics,
internet
things.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(48)
Published: Nov. 29, 2023
Biocompatible
swarming
magnetic
nanorobots
that
work
in
blood
vessels
for
safe
and
efficient
targeted
thrombolytic
therapy
vivo
are
demonstrated.
This
is
achieved
by
using
beads
elaborately
grafted
with
heparinoid-polymer
brushes
(HPBs)
upon
the
application
of
an
alternating
field
B
(
t
).
Because
dense
surface
charges
bestowed
HPBs,
demonstrate
reversible
agglomeration-free
reconfigurations,
low
hemolysis,
anti-bioadhesion,
self-anticoagulation
high-ionic-strength
environments.
They
confirmed
vitro
to
perform
synergistic
thrombolysis
efficiently
“motile-targeting”
drug
delivery
mechanical
destruction.
Moreover,
completion
removal
),
disassemble
into
dispersed
particles
blood,
allowing
them
safely
participate
circulation
be
phagocytized
immune
cells
without
apparent
organ
damage
or
inflammatory
lesion.
provides
a
rational
multifaceted
HPB
biointerfacing
design
strategy
biomedical
general
motile
platform
deliver
drugs
therapies.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(16), P. 15254 - 15276
Published: Aug. 3, 2023
Stimuli-responsive
functional
micro-/nanorobots
(srFM/Ns)
are
a
class
of
intelligent,
efficient,
and
promising
microrobots
that
can
react
to
external
stimuli
(such
as
temperature,
light,
ultrasound,
pH,
ion,
magnetic
field)
perform
designated
tasks.
Through
adaptive
transformation
into
the
corresponding
forms,
they
perfectly
match
demands
depending
on
different
applications,
which
manifest
extremely
important
roles
in
targeted
therapy,
biological
detection,
tissue
engineering,
other
fields.
Promising
srFM/Ns
be,
few
reviews
have
focused
them.
It
is
therefore
necessary
provide
an
overview
current
development
these
intelligent
clear
inspiration
for
further
this
field.
Hence,
review
summarizes
advances
stimuli-responsive
regarding
their
response
mechanism,
achieved
functions,
applications
highlight
pros
cons
stimuli.
Finally,
we
emphasize
existing
challenges
propose
possible
strategies
help
accelerate
study
field
promote
toward
actual
applications.
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: May 29, 2023
Abstract
Micro/nanorobots
can
propel
and
navigate
in
many
hard-to-reach
biological
environments,
thus
may
bring
revolutionary
changes
to
biomedical
research
applications.
However,
current
MNRs
lack
the
capability
collectively
perceive
report
physicochemical
unknown
microenvironments.
Here
we
propose
develop
swarming
responsive
photonic
nanorobots
that
map
local
conditions
on
fly
further
guide
localized
photothermal
treatment.
The
RPNRs
consist
of
a
nanochain
periodically-assembled
magnetic
Fe
3
O
4
nanoparticles
encapsulated
hydrogel
shell,
show
multiple
integrated
functions,
including
energetic
magnetically-driven
motions,
bright
stimuli-responsive
structural
colors,
conversion.
Thus,
they
actively
complex
environments
utilizing
their
controllable
then
visualize
targets
(e.g.,
tumor
lesion)
by
mapping
out
abnormal
pH,
temperature,
or
glucose
concentration)
via
external
light
irradiation
initiate
This
work
facilitates
development
intelligent
motile
nanosensors
versatile
multifunctional
nanotheranostics
for
cancer
inflammatory
diseases.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(14), P. 12971 - 12999
Published: July 11, 2023
Swarms,
which
stem
from
collective
behaviors
among
individual
elements,
are
commonly
seen
in
nature.
Since
two
decades
ago,
scientists
have
been
attempting
to
understand
the
principles
of
natural
swarms
and
leverage
them
for
creating
artificial
swarms.
To
date,
underlying
physics;
techniques
actuation,
navigation,
control;
field-generation
systems;
a
research
community
now
place.
This
Review
reviews
fundamental
applications
micro/nanorobotic
The
generation
mechanisms
emergent
micro/nanoagents
identified
over
past
elucidated.
advantages
drawbacks
different
techniques,
existing
control
systems,
major
challenges,
potential
prospects
discussed.
