An oral microbiota-based deep neural network model for risk stratification and prognosis prediction in gastric cancer

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

Background This study aims to develop an oral microbiota-based model for gastric cancer (GC) risk stratification and prognosis prediction.

Language: Английский

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Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Emerging roles of the gut microbiota in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 22, 2023

Gut microbiota represents a hidden treasure vault encompassing trillions of microorganisms that inhabit the intestinal epithelial barrier host. In past decade, numerous in-vitro , animal and clinical studies have revealed profound roles gut in maintaining homeostasis various physiological functions, especially immune modulation, remarkable differences configuration microbial communities between cancers healthy individuals. addition, although considerable efforts been devoted to cancer treatments, there remain many patients succumb their disease with incremental burden worldwide. Nevertheless, compared stability human genome, plasticity renders it promising opportunity for individualized treatment. Meanwhile, burgeoning findings indicate is involved close interactions outcomes diverse immunotherapy protocols, including checkpoint blockade therapy, allogeneic hematopoietic stem cell transplantation, chimeric antigen receptor T therapy. Here, we reviewed evidence capacity microflora modulate immunotherapies, highlighted opportunities microbiota-based prognostic prediction, as well microbiotherapy by targeting potentiate anticancer efficacy while attenuating toxicity, which will be pivotal development personalized treatment strategies.

Language: Английский

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Engineering Clinically Relevant Probiotics with Switchable “Nano‐Promoter” and “Nano‐Effector” for Precision Tumor Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: Oct. 4, 2023

Probiotics have the potential as biotherapeutic agents for cancer management in preclinical models and human trials by secreting antineoplastic or immunoregulatory tumor microenvironment (TME). However, current probiotics lack ability to dynamically respond unique TME characteristics, leading limited therapeutic accuracy efficacy. Although progress has been made customizing controllable through synthetic biology, engineering process is complex predictability of production relatively low. To address this, here, first time, this work adopts pH-dependent peroxidase-like (POD-like) artificial enzymes both an inducible "nano-promoter" "nano-effector" engineer clinically relevant achieve switchable control probiotic therapy. The nanozyme initially serves "nano-promoter," generating trace amounts nonlethal reactive oxygen species (ROS) stress upregulate acidic metabolites probiotics. Once acidify a threshold, switches "nano-effector," producing great deal lethal ROS fight cancer. This approach shows promise subcutaneous, orthotopic, colitis-associated colorectal tumors, offering new methodology modulating metabolism pathological environment.

Language: Английский

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Insights into the enigma of oral streptococci in carcinogenesis

Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(2)

Published: March 20, 2024

SUMMARYThe genus

Language: Английский

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