A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing DOI

Jumin Yang,

Xin Jin, Wenguang Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: Sept. 11, 2023

Inadequate oxygenation is one of the chief culprits for delayed wound healing. However, current oxygen therapies, such as hyperbaric therapy and topical therapy, face hurdles in providing sustained long-term to reverse hypoxia. Furthermore, their efficacy rejuvenating injury restricted by limited penetration bed. Herein, this study proposes a programmable portable device (named GUFO oxydevice) ingeniously integrating i) controllable generation unidirectional transmission system (COGT-UTS), ii) supramolecular assembled perfluorinated hyperbranched polymer/gelatin (GUF) hydrogel which polymer (FHBP) acts an reservoir ensure convenient replenishment thus directly regulate hypoxic microenvironment. Accelerating healing process oxydevice achieved both diabetic rat acute porcine model without any secondary tissue damages. The present demonstrates that holds promise practically feasible candidate treatment.

Language: Английский

Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics DOI
Dengshuai Wei, Yong Sun,

Hu Zhu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

Citations

111
Designing self-healing hydrogels for biomedical applications DOI
Xiaoya Ding, Lu Fan, Li Wang

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 3929 - 3947

Published: Jan. 1, 2023

Self-healing hydrogels based on various dynamic interactions are comprehensively summarized and their biomedical applications also thoroughly elaborated.

Language: Английский

Citations

61
Extremely strengthening fatigue resistance, elastic restorability and thermodynamic stability of a soft transparent self-healing network based on a dynamic molecular confinement-induced bioinspired nanostructure DOI
Tong Liu,

Chuanlong Li,

Hai Yao

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(8), P. 2968 - 2979

Published: Jan. 1, 2023

Soft self-healing materials are crucial for the development of next-generation wearable electronics that could function in dynamic environments and resist mechanical damage. However, several challenges remain, including fatigue fracture, poor elasticity, thermodynamic lability, which significantly limit their practical applications. Here, with a model system soft polyurea, we propose molecular engineering strategy transforming inherently fragile an island-like structure into resilient ones bicontinuous nanophase separation using 2-ureido-4-pyrimidinone (UPy) supramolecular motifs as structural regulators. The continuous hard domains modified by UPy formed repairable network similar to those reticular layer animal dermis. This design allows simultaneous tremendous improvement threshold (34.8-fold increase), elastic restorability (the maximum elongation full dimensional recovery increasing from 6 times 13 times), stability (4 orders magnitude characteristic flow transition relaxation time), without compromising compliance, autonomous self-healing, optical transparency. These improvements address current limitations unfilled reliable substrates transparent strain-electronics.

Language: Английский

Citations

43
Boron-doped three-dimensional porous carbon framework/carbon shell encapsulated silicon composites for high-performance lithium-ion battery anodes DOI
Junkai Zhao, Bo Wang, Ziheng Zhan

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 664, P. 790 - 800

Published: March 11, 2024

Language: Английский

Citations

43
Viscoelasticity of Polymers with Dynamic Covalent Bonds: Concepts and Misconceptions DOI
Murillo L. Martins, Xiao Zhao, Zoriana Demchuk

et al.

Macromolecules, Journal Year: 2023, Volume and Issue: 56(21), P. 8688 - 8696

Published: Nov. 3, 2023

Polymers with dynamic covalent bonds are an exciting class of materials properties and potential applications that rapidly gain significant attention from diverse scientific communities. While the number publications on this emerging topic increases exponentially, navigating through literature reveals a series physical inconsistencies in previously established concepts some misconceptions data analysis interpretation. The current paper presents practices often applied to characterization systems emphasizes particular may lead critical divergences misinterpretations results. We particularly focus should be avoided interpretation stress–relaxation viscoelastic estimates bond dissociation energy. Instead, we suggest using traditional approaches have been polymer for decades. Lastly, emphasize challenges full understanding microscopic behavior vitrimers.

Language: Английский

Citations

42
A human muscle-inspired, high strength, good elastic recoverability, room-temperature self-healing, and recyclable polyurethane elastomer based on dynamic bonds DOI
Shanshan Wang, Xingyu Chen,

Lizhen Guo

et al.

Composites Science and Technology, Journal Year: 2024, Volume and Issue: 248, P. 110457 - 110457

Published: Jan. 21, 2024

Language: Английский

Citations

33
Strong self-healing close-loop recyclable vitrimers via complementary dynamic covalent/non-covalent bonding DOI Creative Commons
Cheng Wang, Siqi Huo, Guofeng Ye

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157418 - 157418

Published: Nov. 1, 2024

Language: Английский

Citations

29
Smart batteries for powering the future DOI Creative Commons
Qianqian Meng, Yongxin Huang, Li Li

et al.

Joule, Journal Year: 2024, Volume and Issue: 8(2), P. 344 - 373

Published: Feb. 1, 2024

Language: Английский

Citations

25
Multifunctional phase change film with high recyclability, adjustable thermal responsiveness, and intrinsic self-healing ability for thermal energy storage DOI
Bo Yang, Xuelai Zhang,

Jun Ji

et al.

Journal of Energy Chemistry, Journal Year: 2024, Volume and Issue: 97, P. 216 - 227

Published: June 10, 2024

Language: Английский

Citations

19
Strong, healable materials with bio‐like ordered architectures and versatile functionality DOI Creative Commons
Xinkai Li, Yuyan Wang,

Xinxing Zhang

et al.

SusMat, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract The capacity of biological tissues to undergo self‐healing is crucial for the performance functions and continuation life. Conventional intrinsic materials demonstrate analogous functionality depending on dissociation‐recombination reversible bonds with no need extra repair agents. However, trade‐off relationship between mechanical strength kinetics in systems, coupled lack additional functionality, restricts their service life practical applications. Diversified highly ordered structures organisms significantly affect energy dissipation mechanism, signal transmission efficiency, molecular network reconstruction capability due multi‐dimensional differentiated macroscopic composite constructions, microscopic orientation textures, topologies/bonding types at level. These architectures exhibit distinctive strengthening mechanisms functionalities, which provide valuable references. This review aims providing current status advanced biomimetic internal micro/nanostructures. Through highlighting specific examples, classifications, design inspirations, fabrication strategies these newly developed based integrating dynamic interactions nano/microstructures are outlined. Furthermore, balance mechanisms, structure–functionalization relationships, potential application values discussed. concludes a perspective challenges, opportunities, prospects development, application, promotion self‐healable bio‐like architectures.

Language: Английский

Citations

19