Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 703 - 703
Published: Oct. 30, 2024
Hyaluronic
acid
(HA),
an
important
natural
polysaccharide
and
meanwhile,
essential
component
of
extracellular
matrix
(ECM),
has
been
widely
used
in
tissue
repair
regeneration
due
to
its
high
biocompatibility,
biodegradation,
bioactivity,
the
versatile
chemical
groups
for
modification.
Specially,
HA-based
dynamic
hydrogels,
compared
with
conventional
offer
adaptable
network
biomimetic
microenvironment
optimize
process
a
striking
resemblance
ECM.
Herein,
this
review
comprehensively
summarizes
recent
advances
hydrogels
focuses
on
their
applications
articular
cartilage
repair.
First,
fabrication
methods
advantages
HA
are
presented.
Then,
illustrated
from
perspective
cell-free
cell-encapsulated
and/or
bioactive
molecules
(drugs,
factors,
ions).
Finally,
current
challenges
prospective
directions
outlined.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(21)
Published: Nov. 22, 2023
Abstract
Hydrogels
have
emerged
as
powerful
building
blocks
to
develop
various
soft
bioelectronics
because
of
their
tissue‐like
mechanical
properties,
superior
bio‐compatibility,
the
ability
conduct
both
electrons
and
ions,
multiple
stimuli‐responsiveness.
However,
hydrogels
are
vulnerable
damage,
which
limits
usage
in
developing
durable
hydrogel‐based
bioelectronics.
Self‐healing
aim
endow
with
property
repairing
specific
functions
after
failure,
thus
improving
durability,
reliability,
longevity.
This
review
discusses
recent
advances
self‐healing
hydrogels,
from
mechanisms,
material
chemistry,
strategies
for
properties
improvement
hydrogel
materials,
design,
fabrication,
applications
bioelectronics,
including
wearable
physical
biochemical
sensors,
supercapacitors,
flexible
display
devices,
triboelectric
nanogenerators
(TENGs),
implantable
etc.
Furthermore,
persisting
challenges
hampering
development
prospects
proposed.
is
expected
expedite
research
Supramolecular Materials,
Journal Year:
2023,
Volume and Issue:
2, P. 100045 - 100045
Published: Oct. 24, 2023
The
self-healing
capability
of
a
material
refers
to
its
ability
autonomously
heal
fractures
or
defects
and
restore
original
structures
functionalities.
Self-healing
hydrogels,
with
enhanced
lifespan
mechanical
performances
compared
traditional
fragile
can
serve
as
ideal
synthetic
analogues
living
tissues,
holding
great
promise
in
wide
range
biomedical,
electrical
environmental
applications.
Reversible
interactions
play
crucial
roles
the
construction
hydrogel
networks.
A
deep
understanding
these
bonds
is
critical
for
rational
design
hydrogels
desirable
properties.
In
this
short
review,
we
first
introduce
experimental
tools
direct
measurements
reversible
intermolecular
interactions,
followed
by
discussing
via
diverse
noncovalent
(i.e.,
hydrogen
bonding,
ionic
interaction,
metal-ligand
coordination,
hydrophobic
association
π-interactions)
dynamic
covalent
imines,
boronic
esters,
hydrazones
disulfide
bond).
Challenges
our
opinions
on
future
development
are
also
provided.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
Wound
management
has
always
been
a
challenge
in
the
clinical
treatment
of
diabetes.
In
this
study,
glucose
oxidase
(GOx)
is
grafted
onto
natural
pullulan
polysaccharides,
and
oxidization
carried
out
to
form
self‐healing
hydrogel
using
carboxymethyl
chitosan
by
means
reversible
Schiff
base
covalent
bonding.
The
smart‐response
drug
release
properties
are
demonstrated
diabetic
wounds
taking
advantage
two
key
factors,
namely
pH‐responsive
nature
bonding
fact
that
GOx
reduces
pH
wounds.
To
further
enhance
biological
functions
dressing,
exosomes
(Exos)
introduced
into
system.
present
system
improves
high‐glucose
microenvironment
wounds,
releasing
H
2
O
impart
antimicrobial
effects,
ensuring
realizes
function.
component
used
construct
plays
an
effective
antibacterial
role.
Moreover,
Exos
loaded
effectively
promotes
neovascularization
wound.
also
regulates
macrophage
polarization
levels
persistent
inflammation
These
results
suggest
smart
responsive,
multifunctional,
dressing
ideal
for
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 3011 - 3022
Published: Jan. 18, 2024
The
divergent
supramolecular
behavior
of
a
series
tripeptide
stereoisomers
was
elucidated
through
spectroscopic,
microscopic,
crystallographic,
and
computational
techniques.
Only
two
epimers
were
able
to
effectively
self-organize
into
amphipathic
structures,
leading
hydrogels
or
crystals,
respectively.
Despite
the
similarity
between
peptides'
turn
conformations,
stereoconfiguration
led
different
abilities
engage
in
intramolecular
hydrogen
bonding.
Self-assembly
further
shifted
pKa
value
C-terminal
side
chain.
As
result,
across
pH
range
4–6,
only
one
epimer
predominated
sufficiently
as
zwitterion
reach
critical
molar
fraction,
allowing
gelation.
By
contrast,
differing
values
higher
dipole
moment
other
favored
crystallization.
four
tested
for
gold
nanoparticle
(AuNP)
formation,
with
hydrogel
being
key
control
stabilize
AuNPs,
yielding
nanocomposite
that
catalyzed
photodegradation
dye.
Importantly,
AuNP
formation
occurred
without
use
reductants
than
peptide,
redox
chemistry
investigated
by
LC–MS,
NMR,
infrared
scattering-type
near
field
optical
microscopy
(IR
s-SNOM).
This
study
provides
important
insights
rational
design
simple
peptides
minimalistic
green
building
blocks
functional
nanocomposites.
