Recent Progresses in Two‐Dimensional Carbon‐Metal Composites for Catalysis Applications DOI
Yongjie Zhang, Kah Meng Yam, Hao Wang

et al.

Wiley Interdisciplinary Reviews Computational Molecular Science, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 1, 2025

ABSTRACT Catalysis stands as a cornerstone for the global economy and human society, with metals metal oxides assuming significant roles in catalytic research. The emergence of two‐dimensional (2D) carbon materials, such graphene (GR), graphyne (GY), graphdiyne (GDY), boasting unique structural tunable electronic properties, opens up new avenues exploration heterogeneous catalysts. In this review, we initially analyze limitations inherent metal‐ oxide‐based Subsequently, present an overview latest advancements catalysts pertaining to 2D carbon‐metal composites. We categorize these composites into two groups: support‐induced disordered lattices metal‐carbon crystals. realm predominantly encompasses GR‐, GY‐, GDY‐supported single‐atom (SACs), dual‐atom (DACs), single‐cluster (SCCs). Meanwhile, domain crystals primarily includes organic frameworks (MOFs), transition carbides (MXenes), graphite (g‐MCs). This review encapsulates comprehensive understanding structure, stability, application all from theoretical standpoint, placing particular emphasis on coordination structure –performance relationship. To conclude, brief summary outlook are provided, offering insights future study

Language: Английский

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol DOI Creative Commons
Chengshuai Yang, Yan Wang, Zhen Su

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 15, 2024

Abstract Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have characterized, stepwise reactions from the well-characterized di-oxygenated taxoids to tetracyclic core skeleton are yet be elucidated. Here, we uncover pathways for few tri-oxygenated via confirming critical reaction order of second third hydroxylation steps, unearth taxoid 9 α -hydroxylase catalyzing fourth hydroxylation, identify CYP725A55 oxetane ester formation cascade oxidation-concerted acyl rearrangement mechanism. After identifying acetyltransferase C7-OAc, producing highly-oxygenated 1 β -dehydroxybaccatin VI with elucidated its complete biosynthesis taxa-4(20),11(12)-diene-5 -ol achieved an engineered yeast. These systematic studies lay foundation elucidation Taxol.

Language: Английский

Citations

23
Covalent Organic Framework Membranes with Patterned High-Density Through-Pores for Ultrafast Molecular Sieving DOI
Li Cao, Cailing Chen, Shuhao An

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21989 - 21998

Published: July 26, 2024

The creation of uniformly molecular-sized through-pores within polymeric membranes and the direct evidence these pores are essential for fundamentally understanding transport mechanism improving separation efficiency. Herein, we report an electric-field-assisted interface synthesis approach to fabricating large-area covalent organic framework (COF) that consist preferentially oriented single-crystalline COF domains. These frameworks were translated into high-density, vertically aligned across entire membrane, enabling visualization membrane with ultrahigh resolution 2 Å using low-dose high-resolution transmission electron microscopy technique (HRTEM). density directly visualized was quantified be 1.2 × 10

Language: Английский

Citations

18
Total Synthesis of Enlicitide Decanoate DOI
Hongming Li, David A. Thaisrivongs,

Gao Shang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

We report the total synthesis of enlicitide decanoate, an orally bioavailable inhibitor proprotein convertase subtilisin/kexin type 9 that is being developed for treatment atherosclerotic cardiovascular disease. It a highly complex macrocyclic peptide with significant number nonpeptide structural elements presents daunting synthetic chemistry challenge. describe development convergent, efficient, and robust manufacturing process enables large-scale production enlicitide.

Language: Английский

Citations

2
Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products DOI Open Access
Huan An,

Xuehui Deng,

Fang Wang

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2292 - 2292

Published: May 12, 2023

Natural products have proven their value as drugs that can be therapeutically beneficial in the treatment of various diseases. However, most natural low solubility and poor bioavailability, which pose significant challenges. To solve these issues, several drug nanocarriers been developed. Among methods, dendrimers emerged vectors for due to superior advantages, such a controlled molecular structure, narrow polydispersity index, availability multiple functional groups. This review summarizes current knowledge on structures dendrimer-based compounds, with particular focus applications alkaloids polyphenols. Additionally, it highlights challenges perspectives future development clinical therapy.

Language: Английский

Citations

33
Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel DOI Creative Commons
Shengnan Zhang,

Taiqiang Ye,

Yibin Liu

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(22), P. 7517 - 7517

Published: Nov. 10, 2023

Paclitaxel, a natural secondary metabolite isolated and purified from the bark of Taxus tree, is considered one most successful anticancer drugs due to its low toxicity, high potency broad-spectrum activity. trees are scarce slow-growing, with extremely paclitaxel content, contradiction between supply demand in market becoming more intense. Therefore, researchers have tried obtain by various methods such as chemical synthesis, artificial culture, microbial fermentation tissue cell culture meet clinical for this drug. This paper provides comprehensive overview extraction, combination therapy, total semi-synthesis biosynthesis recent years an outlook, aiming provide theoretical basis reference further research on production application future.

Language: Английский

Citations

28
Chiral drugs: Sources, absolute configuration identification, pharmacological applications, and future research trends DOI Creative Commons
Shoujiao Peng,

Yuying Zhu,

Chunying Luo

et al.

LabMed discovery., Journal Year: 2024, Volume and Issue: 1(1), P. 100008 - 100008

Published: July 29, 2024

Chirality is one of the essential attributes nature. Chiral drugs refer to a class containing chiral centers, and molecular stereo-structures their enantiomers are non-superimposable mirror images each other. Sixty percent commonly used drugs, including those from traditional Chinese medicine (TCM), chiral. Developing single enantiomer with high efficiency low toxicity has drawn considerable attention due significant differences in pharmacological activities, metabolic processes, exhibited by drugs. This review concisely summarizes sources, absolute configuration identification, applications, future research trends, particularly TCM.

Language: Английский

Citations

9
From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human health DOI Creative Commons

Xiulan Xie,

Yaohua Zhai,

Hao Cheng

et al.

Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 220, P. 109502 - 109502

Published: Jan. 12, 2025

Language: Английский

Citations

1
Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors DOI
Zhenyu Gong,

Dairan Zhou,

Dejun Wu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123180 - 123180

Published: Feb. 13, 2025

Language: Английский

Citations

1
Recent progress in the construction of eight-membered nitrogen-heterocycles DOI
Jia Li, Ziyang Dong, Changgui Zhao

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(11), P. 4645 - 4669

Published: Jan. 1, 2024

This review summarized the progress in synthesizing eight-membered N-heterocycles over past two decades (1995–2023), inspiring synthetic chemists to develop more efficient strategies for construction of these skeletons.

Language: Английский

Citations

8
Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses DOI

Xitong Song,

Qian Wang,

Xiaoxi Zhu

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(6), P. 3912 - 3925

Published: Feb. 26, 2024

Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses long-standing challenge due to poor product selectivity. Taxadiene-5α-hydroxylase (CYP725A4) plays crucial role in the biosynthesis of paclitaxel, catalyzing oxidation taxadiene and iso-taxadiene. This process yields several products, including byproducts 5(12)-oxa-3(11)-cyclotaxane (OCT) 5(11)-oxa-3(11)-cyclotaxane (iso-OCT), as well target compound taxadien-5α-ol (T5OH). Despite extensive studies, molecular mechanism CYP725A4-catalyzed transformations still elusive, which could impede our understanding further engineering paclitaxel biosynthetic pathway. In this study, crystal structure CYP725A4 complex with elucidated. Through comprehensive computational analyses, catalytic mechanisms natural are deciphered. Our calculations indicate that affords zwitterion intermediate, can undergo two competing transformation routes. One involves formation epoxide, undergoes water-mediated rearrangement form T5OH product. alternative pathway, protonation oxygen intermediate facilitates subsequent hydride transfer carbon–oxygen coupling, resulting side products OCT/iso-OCT. Contrary taxadiene, hydroxylation at C5 iso-taxadiene directly T5OH. These crystallographic studies analyses have yielded valuable insights into laid foundation for CYP725A4.

Language: Английский

Citations

8