Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 5, 2024

This review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability retention, as well active using ligand-receptor strategies. also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision effectiveness. A significant focus is placed on crucial role radiopharmaceuticals in medical imaging theranostics, highlighting their contribution to diagnostic accuracy image-guided curative interventions. emphasizes safety considerations strategies for mitigating side effects, providing valuable insights addressing challenges achieving precise delivery. Looking ahead, nanoparticle formulations cutting-edge innovations next-generation showcasing potential applications. Real-world examples are presented case studies, including use radiolabelled antibodies solid tumors, peptide receptor radionuclide therapy neuroendocrine intricate management bone metastases. concluding perspective envisions future trajectory anticipating a harmonious integration medicine artificial intelligence. vision foresees an era aligns seamlessly with scientific advancements, ushering new epoch marked by fusion resonance visionary progress.

Language: Английский

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Photoactivation Inducing Multifunctional Coupling of Fluorophore for Efficient Tumor Therapy In Situ

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 15, 2024

Abstract Photoactivatable molecules, with high‐precision spatialtemporal control, have largely promoted bioimaging and phototherapy applications of fluorescent dyes. Here, the first photoactivatable sensor ( BI ) is described that can be triggered by broad excitation light (405–660 nm), which further undergoes intersystem crossing H‐atom transfer processes to forming superoxide anion radicals (O 2 −• carbon radicals. Particularly, photoinduced gain carbon‐centered BI• allows for radical‐radical coupling afford combined crosslink product BI─BI ), would oxidized in presence O produce an extended conjugate system near infrared emission (820 nm). Besides, photochemically generated Cy─BI possesses ultra‐high photothermal conversion efficiency up 90.9%, optimized potential. What′s more, Western Blot assay reveals both photoproduct efficiently inhibit expression CHK1, irradiation induces apoptosis ultimately enhances phototherapeutic effects. Thus, combination cell cycle block inducing apoptosis, photodynamic therapy treatments significantly suppress solid tumor vivo antitumor efficacy explorations. This a novel finding developing as well applicability photoimaging tumor‐related areas.

Language: Английский

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Multifunctional microwave absorption materials: construction strategies and functional applications

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5874 - 5894

Published: Jan. 1, 2024

Classification and multifunctional scalability of advanced microwave absorbing materials.

Language: Английский

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Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

ACS Nano, Journal Year: 2024, Volume and Issue: 18(18), P. 11560 - 11572

Published: April 29, 2024

Second near-infrared (NIR-II) carbon dots, with absorption or emission between 1000 and 1700 nm, are gaining increasing attention in the biomaterial field due to their distinctive properties, which include straightforward preparation processes, stable photophysical characteristics, excellent biocompatibility, low cost. As a result, there is growing focus on controlled synthesis modulation of photochemical properties NIR-II aim further expand biomedical applications, current research hotspot. This account aims provide comprehensive overview recent advancements dots within field. The review will cover following topics: (i) design, synthesis, purification (ii) surface modification strategies, (iii) particularly domain cancer theranostics. Additionally, this addresses challenges encountered by outline future directions realm By exploring carbon-based biomaterials, we can anticipate that contribution garner increased contribute development next-generation advanced functional thereby offering enhanced tools strategies

Language: Английский

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Engineering Near‐Infrared Plasmonic Spiky Gold Nanostructures for Highly Efficient Surface‐Enhanced Raman Spectroscopy‐Guided Cancer Hyperthermia Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract Cancer phototheranostics utilizing plasmonic materials is attracting considerable interest due to its high spatiotemporal precision and specificity, remote controllability, superior therapeutic efficacy, low systemic side effects. Exploring new with excellent photothermal properties at the frontier of cancer phototheranostics. Herein, this work systematically investigates spiky Au nanoparticles (NPs) different shaped central cores – nanosphere , nanocube nanorod (AuNR). It shown that shape core in NPs has significant effects on their surface‐enhanced Raman spectroscopy (SERS) performances, a spherical or cubic are much for near‐infrared (NIR) SERS detection hyperthermia therapy comparison AuNRs. The NP‐based probes demonstrate remarkable capability imaging live cells dynamic visualization tumors 4T1 breast tumor mouse model after intravenous administration. Moreover, vivo studies show exceptional such against under NIR irradiation. This study suggests potential utility efficient SERS‐guided therapy.

Language: Английский

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H₂S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

ACS Nano, Journal Year: 2023, Volume and Issue: 17(19), P. 19242 - 19253

Published: Oct. 2, 2023

Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone gas. However, microwave (MW) not selective against tumors, residual tumors after incomplete ablation will generate immunosuppression, ultimately making prone to recurrence metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) proposed reverse immunosuppression reactivate antitumor immune effect through responsively releasing H2S in tumor cells for improving MWTT. Under MW irradiation, BMCPH mediate MWTT ablate release l-cysteine (l-Cys) react highly expressed cystathionine β-synthase H2S. The generated can inhibit accumulation myeloid-derived suppressor (MDSCs) promote expression cytotoxic T lymphocytes (CTLs). Moreover, Bi-MOF also scavenge reactive oxygen species (ROS), major means MDSCs-mediated further weaken immunosuppressive effect. Simultaneously, surface-covered HA gather CTLs around enhance response. This nano gas immunomodulator provides an idea sensitive tunable unstable molecules at sites. strategy response introduces direction reduce risk metastasis ablation.

Language: Английский

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Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: March 6, 2024

Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means target-delivering heat. Conventional thermal methods, such as radiofrequency or microwave ablation, to certain extent, are subjected extended time well biosafety risks unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains fresh perspective, thanks magnetic hyperthermia. In this respect, an injectable- magnetic-hydrogel-construct-based agent likely be candidate for aforementioned clinical translation. Adopting simple environment-friendly strategy, colloidal hydrogel injection introduced binary system comprising super-paramagnetic Fe

Language: Английский

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Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy

Light Science & Applications, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 3, 2024

Abstract Chemotherapy is one of the conventional treatments for cancer in clinical practice. However, poor delivery efficiency, systemic toxicity, and lack pharmacokinetic monitoring during treatment are critical limitations current chemotherapy. Herein, we reported a brand-new antitumor drug strategy that harnesses an optical fiber endoscopically therapeutic probe. The probe carries photosensitizers core agents on surface mediated by temperature-responsive hydrogel film, giving rise to activable photothermal-chemotherapy orchestrates localized hyperthermia thermal-stimuli release tumor lesion. Furthermore, dynamical in-situ temperature can be real-time supervised through built-in sensors, including reflective Mach–Zehnder interferometer Bragg grating, visualize therapy process thus improve safety treatment. Compared with methods, fiber-optic adequately take advantage chemotherapeutics collaboratively recruiting photoheating-mediated enhanced permeability particle-assisted high retention, shedding new light “central-to-peripheral” pervasion retention mechanism destroy tumors completely. chemotherapy incorporates precise delivery, accurate controllability release, tumor, low off-target rate, feedback, performing straightforward pathway. More than that, proposed holds tremendous promise provide revolutionized on-demand platform highly efficient evaluation screening pharmaceuticals.

Language: Английский

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Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 374 - 383

Published: May 10, 2024

Implant-related osteomyelitis is a formidable hurdle in the clinical setting and characterized by inflammation, infection, consequential bone destruction. Therefore, effective reactive oxygen species (ROS) scavenging, bacterial killing, subsequent tissue repair are urgently needed for treatment of difficult-to-heal osteomyelitis. Herein, we utilized eddy-thermal effect magnesium (Mg) implants under an alternating magnetic field (AMF) controlled release H

Language: Английский

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H₂S‐Mediated Gas Therapy and HSP90 Downregulation Synergically Enhance Tumor Microwave Thermal Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 23, 2024

Abstract Microwave thermal therapy (MWTT) is a novel clinical treatment of tumors via inducing effect and anti‐tumor immune response, exhibiting advantages deep penetration, minimal invasion, high heat conversion efficiency. However, effective ablation difficult to cover the entire tumor area, heat‐shock protein 90 (HSP90) often upregulated after generate tolerance sublethal weaken induced antitumor effect, resulting in rate recurrence metastasis. Herein, multifunctional nanoregulator metal phenolic network‐coated ZnS (ZnS@Ga‐tannic acid, ZGT) proposed release H 2 S for synergically enhancing MWTT. Under costimulation MW radiation acidic microenvironment, ZGT can improve effects promote damage induce apoptosis. The released also inhibit production ATP then downregulate expression HSP90, strengthening activated systemic response ablation. This provides new way achieving compensation strategy gas HSP90 positively regulate introduces direction reducing risk metastasis therapy.

Language: Английский

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