Chemical Communications, Journal Year: 2024, Volume and Issue: 60(64), P. 8419 - 8422
Published: Jan. 1, 2024
Light and pH dual-responsive ion transporters offer better applicability for cancer due to higher tunability low cytotoxicity. Herein, we demonstrate the development of pH-responsive β-carboline-based ionophores photocleavable-linker appended proionophores facilitate controlled transport Cl
Language: Английский
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(50), P. 27167 - 27184
Published: Dec. 8, 2023
Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer membranes. This has inspired chemists to attempt develop synthetic analogues exploit membrane confinement and transmembrane potential gradients, much like their biological cousins. In this perspective, we outline the various strategies by which machines─molecular systems in a nanomechanical motion is exploited for function─have been designed be incorporated membranes utilized mediate transport. We survey machines spanning both switches motors, those that act as mobile carriers or are anchored membrane, mechanically interlocked molecules, examples activated response external stimuli.
Language: Английский
Citations
23
Science, Journal Year: 2024, Volume and Issue: 385(6708), P. 544 - 549
Published: Aug. 1, 2024
Pumping ions against a concentration gradient through protein-based transporters is cornerstone of numerous biological processes. Mimicking this function by using artificial receptors remains daunting challenge, mainly because the difficulties in balancing between requirement for high binding affinities and precise on-demand ion capture release properties. We report trimeric hydrazone photoswitch-based receptor that converts light energy into work actively transporting chloride anion dichloromethane liquid membrane, functioning as molecular pump. The system manifests ease synthesis, bistability, excellent photoswitching properties, superb ON-OFF properties (difference up to six orders magnitude).
Language: Английский
Citations
16
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(22)
Published: March 22, 2024
Artificial ion transport systems have emerged as an important class of compounds that promise applications in chemotherapeutics anticancer agents or to treat channelopathies. Stimulus-responsive offer spatiotemporally controlled activity for targeted remain rare. Here we utilize dynamic hydrogen bonding interactions a 4,6-dihydroxy-isophthalamide core generate modular platform enabling access stimuli-responsive transporters can be activated response wide variety external stimuli, including light, redox, and enzymes, with excellent OFF-ON activation profiles. Alkylation the two free hydroxyl groups stimulus-responsive moieties locks amide bonds through intramolecular hence makes them unavailable anion binding transport. Triggering using particular stimulus cleave both cages reverses arrangement, highly preorganized cavity efficient transmembrane Integration are responsive orthogonal stimuli enables multi-stimuli activation, where required trigger AND logic process. Importantly, strategy provides facile method post-functionalize active transporter multiple triggers.
Language: Английский
Citations
13
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Photoisomerization of a [2]catenane-based receptor functionalized with stiff-stilbene allows for on demand uptake and release chloride ions.
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(44)
Published: July 21, 2023
Abstract Synthetic supramolecular ion transporters find applications as potential therapeutics and tools for engineering functional membranes. Stimuli‐responsive systems enable external control over transport, which is necessary targeted activation. The Minireview provides an overview of current approaches to developing stimuli‐responsive transport systems, including channels mobile carriers, that can be controlled using photo or redox inputs.
Language: Английский
Citations
20
Chemical Science, Journal Year: 2024, Volume and Issue: 15(37), P. 15006 - 15022
Published: Jan. 1, 2024
Synthetic anion receptors based on sigma-hole interactions are increasingly used to transport anions across membranes. This article discusses the progress in field and prospects for biological applications.
Language: Английский
Citations
7
ChemPlusChem, Journal Year: 2023, Volume and Issue: 88(12)
Published: Aug. 28, 2023
The utilisation of light to achieve precise manipulation and control over the structure function supramolecular assemblies has emerged as a highly promising approach in development complex, configurable, or multifunctional systems nanoscopic machine-like entities. In this minireview, we highlight recent examples self-assembled covalently bound cages macrocycles with focus on external internal functionalisation photoswitchable unit embedment photoswitch into framework structure. Functionalising interior exterior cage macrocycle photoresponsive group enables different properties, such guest binding assembly solid-state, while overall shape often undergoes no significant change. By directly integrating structure, isomerisation can either induce geometry change, disassembly, disassembly reassembly Historical covered review are based azobenzene, diarylethene, stilbene photoswitches, alkene motors that were incorporated constructed by metal-organic, dynamic covalent, covalent bonds.
Language: Английский
Citations
14
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This article presents the use of dynamic covalent chemistry in liposomal membranes to activate and modulate transmembrane transport chloride by addition different azine-containing compounds.
Language: Английский
Citations
0
ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Abstract The transmembrane transport of anions is a promising application synthetic anion receptors. Numerous anionophores have been developed for chloride over the past decades. Despite biological relevance phosphate and esters, very few reports on their by systems exist. Here we report systematic study diphenyl phosphate, phenyl inorganic five different anionophores. these phosphates into liposomes was monitored fluorescence spectroscopy, 31 P NMR an ion selective electrode. results experiments showed that readily transported most ionophores. more challenging but can be enhanced better shielding group. Inorganic to this achieved using macrocyclic anionophore with eight preorganised H‐bond donors. These pave way development as well esters.
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Language: Английский
Citations
0