Wearable electrochemical patch based on iron nano-catalysts incorporated laser-induced graphene for sweat metabolites detection

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 249, P. 116012 - 116012

Published: Jan. 6, 2024

Language: Английский

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Conductive Polymer-Based Hydrogels for Wearable Electrochemical Biosensors

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 459 - 459

Published: July 12, 2024

Hydrogels are gaining popularity for use in wearable electronics owing to their inherent biomimetic characteristics, flexible physicochemical properties, and excellent biocompatibility. Among various hydrogels, conductive polymer-based hydrogels (CP HGs) have emerged as candidates future sensor designs. These can attain desired properties through tuning strategies extending from molecular design microstructural configuration. However, significant challenges remain, such the limited strain-sensing range, hysteresis of sensing signals, dehydration-induced functional failure, surface/interfacial malfunction during manufacturing/processing. This review summarizes recent developments polymer-hydrogel-based electrochemical biosensors over past five years. Initially serving carriers biomolecules, sensors advanced encompass a wider range applications, including development non-enzymatic facilitated by integration nanomaterials metals, metal oxides, carbon-based materials. Beyond numerous existing reports that primarily focus on biomolecule detection, we extend scope include fabrication nanocomposite polymer explore varied conductivity mechanisms applications. comprehensive evaluation is instrumental determining readiness these point-of-care translation state-of-the-art applications technology.

Language: Английский

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A Review of Recent Advances in Microneedle-Based Sensing within the Dermal ISF That Could Transform Medical Testing

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(3), P. 1149 - 1161

Published: March 13, 2024

Interstitial fluid (ISF) has attracted extensive attention in an extremely wide range of areas due to its unique advantages, such as portability, high precision, comfortable operation, and superior stability. In recent years, the microneedle (MN) technique been considered be excellent tool for extracting ISF because it is painless noninvasive. Recent reports have shown that MN good application prospects extraction. this review, we provide comprehensive in-depth insight into integrated devices detection, covering basic structure well fabrication various applications Challenges are highlighted, with a discussion on how transition MN-integrated toward personalized healthcare monitoring systems.

Language: Английский

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Laser‐Induced Nanozyme Biofuel Cell‐Based Self‐Powered Patch for Accelerating Diabetic Wound Healing With Real‐Time Monitoring

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Chronic wounds are a common complication of diabetes, causing significant inconvenience, persistent pain, and economic burden to patients. Real‐time monitoring wound status timely treatment with intelligent dressings is promising way treat infection accelerate healing. However, the traditional make it difficult simultaneously maintain true state meet dynamic needs chronic wounds. Herein, multifunctional self‐powered patch (MSPP) featured antibacterial, hypoglycemic, electrical stimulation designed promote healing real‐time status, in which laser‐induced nanozyme electrodes prepared situ through laser scanning technology construct highly stable nanozyme‐based glucose biofuel cells (GBFCs). Enzymatic cascade reaction GBFCs can use local hyperglycemia produce reactive oxygen species effective antibacterial properties, reduce while generating microcurrent, further diabetes In just 10 days, patch‐treated group achieves 100% shrinkage. Meanwhile, pH sensing module MSPP also monitor fluctuations correct test results, improving accuracy. brief, construction provides solutions for developing closed‐loop biomedical systems that integrate monitoring, diagnosis, treatment.

Language: Английский

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Photoexcited CuO/TiO₂ Heterojunction for Photoelectrochemical Sensors for Nonenzymatic Glucose Detection

Langmuir, Journal Year: 2025, Volume and Issue: 41(2), P. 1526 - 1535

Published: Jan. 10, 2025

Photoelectrochemical sensors have been studied for glucose detection because of their ability to minimize background noise and unwanted reactions. Titanium dioxide (TiO2), a highly efficient material in converting light into electricity, cannot utilize visible light. In this regard, we developed nonenzymatic sensor by using simple one-step electrospinning technique combine cupric oxide with TiO2 create heterojunction. The prepared nanofibers exhibit an extremely high aspect ratio dense structure. These characteristics enhance the quantity electron-hole pairs generated speed at which electrons are transferred. They also reduce distance that charges need travel offer reactive sites catalytic oxidation glucose. has direct proportional reaction within concentration ranging from 30 μM 2 mM under sunlight conditions. It achieves limit 9.9 signal-to-noise 3. excellent stability, reproducibility, selectivity. This study provides insights development photoelectrochemical detect

Language: Английский

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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation

Bioelectronic Medicine, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 20, 2025

Abstract The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. Early innovations, such as cardiac pacemakers and deep brain stimulation, paved the way for these sophisticated technologies. This review traces historical technological progression medicine, culminating in emerging potential devices multiple disorders body. We emphasize both invasive techniques, implantable brain, spinal cord autonomic regulation, while we introduce new prospects non-invasive neuromodulation, including focused ultrasound newly developed neurography enabling precise detection titration inflammatory immune responses. case neuromodulation (incorporating splenic stimulation) is presented through its applications conditions sepsis chronic inflammation, illustrating capacity revolutionize personalized healthcare. Today, or have yet be dynamically modulate nervous system function by responding molecular signals; it represents a transformative approach therapeutic interventions major opportunity which may advance. Knowledge gaps remain likely contribute lack available closed loop systems, namely, (1) significant exogenous endogenous noise must filtered out, (2) drift signal due temporal change disease severity and/or therapy induced neuroplasticity, (3) confounding effects (e.g., concurrent medications dysregulate functions). Leveraging continuous feedback adjustments overcome many barriers, next generation stand at forefront precision offering avenues individualized treatment.

Language: Английский

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Aspects of Electrochemical Biosensors Using Affinity Assays

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 166 - 166

Published: March 4, 2025

In recent decades, the utilization of biomarkers has gained increasing attention. The timely identification and quantification proteins, nucleic acids, small molecules associated with a medical condition, infection, or contaminant have become increasingly crucial across variety fields, including medicine, food safety, quality/environmental control. State-of-the-art biomarker detection methods predominantly rely on standard immunoassay techniques, requiring specialized laboratory equipment trained personnel. This impedes broad commercial implementation biosensors in, e.g., Point-of-Care (PoC) settings where ease operation, portability, cost-efficiency are prioritized. Small, robust electrochemical promising alternative for analyzing in complex samples within PoC environments. Therefore, creating designing optimized sensing surfaces, immobilization strategies, efficient signal generation improving biosensor systems, which turn can real-world impact. present paper, we reviewed common electrode types geometries used approaches, discussed advantages drawbacks different methods, presented labeling strategies enhancement.

Language: Английский

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Vertical-Aligned and Ordered-Active Architecture of Heterostructured Fibers for High Electrochemical Capacitance

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(1), P. 312 - 328

Published: Jan. 5, 2024

Language: Английский

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Harvesting and manipulating sweat and interstitial fluid in microfluidic devices

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1244 - 1265

Published: Jan. 1, 2024

This review focuses on microfluidic techniques for sampling, sensing, and managing of sweat interstitial fluid (ISF).

Language: Английский

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Research progress in non-precious metal oxide/compound-based electrodes for non-enzymatic electrochemical glucose sensor applications

Materials Science in Semiconductor Processing, Journal Year: 2024, Volume and Issue: 181, P. 108643 - 108643

Published: June 24, 2024

Language: Английский

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