Biofluid-Permeable and Erosion-Resistant Wireless Neural-Electronic Interfaces for Neurohomeostasis Modulation DOI
Zhidong Wei,

Fei Jin,

Tong Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Neural-electronic interfaces through delivering electroceuticals to lesions and modulating pathological endogenous electrical environments offer exciting opportunities treat drug-refractory neurological disorders. Such an interface should ideally be compatible with the neural tissue aggressive biofluid environment. Unfortunately, no specifically designed for is available so far; instead, simply stacking encapsulation layer on silicon-based substrates makes them susceptible leakage, device malfunction, foreign-body reactions. Here, we developed a biofluid-permeable erosion-resistant wireless neural-electronic (BNEI) that composed of flexible 3D interconnected poly(l-lactide) fibrous network dense axially aligned piezoelectrical molecular chain arrangement architecture. The organized structure enhances tortuous pathway longitudinal piezoelectric coefficient fibers, improves their water barrier properties, enables efficient conversion low-intensity acoustic vibrations transmitted in biofluids into signals, achieving long-term stable neuromodulation. A 3-month clinical trial demonstrated BNEI can effectively accelerate cascade peripheral neuropathy nerve regeneration transcranially modulate cerebellar-cerebral circuit dynamics, suppressing seizures temporal lobe epilepsy. clinically scalable approach neuromodulation broadly applicable modulation neurohomeostasis both central nervous systems.

Language: Английский

Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

28
Advances in the Use of Conducting Polymers for Healthcare Monitoring DOI Open Access
Lê Văn Cường, Hyeonseok Yoon

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1564 - 1564

Published: Jan. 26, 2024

Conducting polymers (CPs) are an innovative class of materials recognized for their high flexibility and biocompatibility, making them ideal choice health monitoring applications that require flexibility. They active in design. Advances fabrication technology allow the incorporation CPs at various levels, by combining diverse monomers with metal particles, 2D materials, carbon nanomaterials, copolymers through process polymerization mixing. This method produces unique physicochemical properties is highly customizable. In particular, development expanded surface area conductivity has significantly improved performance sensors, providing sensitivity expanding range available options. However, due to morphological diversity new thus variety characteristics can be synthesized other types functionalities, choosing right combination a sensor application difficult but becomes important. review focuses on classifying role CP highlights recent advances design, especially field healthcare monitoring. It also synthesizes sensing mechanisms evaluates electrochemical surfaces Furthermore, revolutionized will discussed detail.

Language: Английский

Citations

27
Advances in bio-integrated wearable and implantable optoelectronic devices for cardiac healthcare DOI Creative Commons
Cheng Li,

Yangshuang Bian,

Zhiyuan Zhao

et al.

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous comfortable for patients. Recently, wearable implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological in an imperceptible spatiotemporally unconstrained manner, opening countless possibilities intelligent healthcare paradigm. To achieve biointegrated cardiac healthcare, researchers have focused on novel strategies construction flexible/stretchable systems. Here, we overview progress flexible stretchable optoelectronics devices. Firstly, device design addressed, including mechanical design, interface adhesion, encapsulation strategies. Next, practical applications monitoring, optogenetics, nongenetic stimulation are presented. Finally, outlook systems discussed.

Language: Английский

Citations

22
Bioelectronic Implantable Devices for Physiological Signal Recording and Closed‐Loop Neuromodulation DOI Creative Commons
Saehyuck Oh, Janghwan Jekal, Jia Liu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Bioelectronic implantable devices are adept at facilitating continuous monitoring of health and enabling the early detection diseases, offering insights into physiological conditions various bodily organs. Furthermore, these advanced systems have therapeutic capabilities in neuromodulation, demonstrating their efficacy addressing diverse medical through precise delivery stimuli directly to specific targets. This comprehensive review explores developments applications bioelectronic within biomedical field. Special emphasis is placed on evolution closed‐loop systems, which stand out for dynamic treatment adjustments based real‐time feedback. The integration Artificial Intelligence (AI) edge computing technologies discussed, significantly bolster diagnostic functions devices. By elemental analyses, current challenges, future directions devices, aims guide pathway advances

Language: Английский

Citations

18
Hydro-locking in hydrogel for extreme temperature tolerance DOI
Xiaochen Zhang, Dong Li, Xuxu Yang

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6737), P. 967 - 973

Published: Feb. 27, 2025

Hydrogels consist of cross-linked polymers that are highly swollen with water. Water evaporation or freezing during temperature changes may lead to stiff and brittle hydrogels. We introduce a strategy called “hydro-locking,” which involves immobilizing the water molecules within polymer network hydrogel. This is accomplished by establishing robust connections between using sulfuric acid. A sacrificial introduced shield prime from collapsing. Under hydro-locking mode, an alginate-polyacrylamide double-network hydrogel remains soft stretchable range spans –115° 143°C. The works hydrogels solutions enable preservation observation materials even living organisms at extreme temperatures.

Language: Английский

Citations

6
Conducting Hydrogel‐Based Neural Biointerfacing Technologies DOI Open Access
Pei Zhang, Yifan Yang,

Zhaobo Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Language: Английский

Citations

2
Millimetre-scale bioresorbable optoelectronic systems for electrotherapy. DOI
Yamin Zhang, Eric Rytkin, Liangsong Zeng

et al.

PubMed, Journal Year: 2025, Volume and Issue: 640(8057), P. 77 - 86

Published: April 1, 2025

Language: Английский

Citations

2
Aptamer Renaissance for Neurochemical Biosensing DOI Creative Commons

Annina Stuber,

Nako Nakatsuka

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2552 - 2563

Published: Jan. 18, 2024

Unraveling the complexities of brain function, which is crucial for advancing human health, remains a grand challenge. This endeavor demands precise monitoring small molecules such as neurotransmitters, chemical messengers in brain. In this Perspective, we explore potential aptamers, selective synthetic bioreceptors integrated into electronic affinity platforms to address limitations neurochemical biosensing. We emphasize importance characterizing aptamer thermodynamics and target binding realize functional biosensors biological systems. focus on two label-free spanning micro- nanoscale: field-effect transistors nanopores. Integration well-characterized structure-switching aptamers overcame nonspecific binding, challenge that has hindered translation from lab clinic. transformative era driven by neuroscience breakthroughs, technological innovations, multidisciplinary collaborations, an renaissance holds bridge gaps reshape landscape diagnostics neuroscience.

Language: Английский

Citations

17
Degradable π-Conjugated Polymers DOI
Azalea Uva,

Sofia Michailovich,

Nathan Sung Yuan Hsu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(18), P. 12271 - 12287

Published: April 24, 2024

The integration of next-generation electronics into society is rapidly reshaping our daily interactions and lifestyles, revolutionizing communication engagement with the world. Future promise stimuli-responsive features enhanced biocompatibility, such as skin-like health monitors sensors embedded in food packaging, transforming healthcare reducing waste. Imparting degradability may reduce adverse environmental impact lead to opportunities for monitoring. While advancements have been made producing degradable materials encapsulants, substrates, dielectrics, availability conducting semiconducting remains restricted. π-Conjugated polymers are promising candidates development conductors or semiconductors due ability tune their stimuli-responsiveness, mechanical durability. This perspective highlights three design considerations: selection π-conjugated monomers, synthetic coupling strategies, degradation polymers, generating electronics. We describe current challenges monomeric present options circumvent these issues by highlighting biobased compounds known pathways stable monomers that allow chemically recyclable polymers. Next, we strategies compatible synthesis including direct arylation polymerization enzymatic polymerization. Lastly, discuss various modes depolymerization characterization techniques enhance comprehension potential byproducts formed during polymer cleavage. Our considers parameters parallel rather than independently while having a targeted application mind accelerate discovery high-performance organic

Language: Английский

Citations

15
Minimizing the Environmental Impacts of Plastic Pollution through Ecodesign of Products with Low Environmental Persistence DOI Creative Commons
Bryan D. James, Collin P. Ward, Mark E. Hahn

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(3), P. 1185 - 1194

Published: Jan. 8, 2024

While plastic pollution threatens ecosystems and human health, the use of products continues to increase. Limiting its harm requires design strategies for informed by threats that plastics pose environment. Thus, we developed a sustainability metric ecodesign with low environmental persistence uncompromised performance. To do this, integrated degradation rate into established material selection strategies, deriving indices persistence. By comparing impact on-the-market proposed alternatives, show accounting in could translate societal benefits hundreds millions dollars single consumer product. Our analysis identifies materials their properties deserve development, adoption, investment create functional less environmentally impactful products.

Language: Английский

Citations

12