Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216548 - 216548
Published: Feb. 26, 2025
Language: Английский
Citations
2
Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)
Published: Aug. 23, 2024
Abstract In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events disease diagnosis. The utilization versatile fluorescent probes in fluorescence imaging offers a powerful tool vivo biomarkers closely associated pathological conditions. However, the dynamic behavior leading to rapid clearance small molecule from regions interest severely compromises their potential imaging. Notably, self‐immobilizing that selectively recognize diseased tissues while improving retention enrichment enable accurate high‐fidelity this review, we aim summarize strategies employed recent advances performance precision using techniques. Lastly, discuss prospects challenges promote further development application more delicate probes.
Language: Английский
Citations
13
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Vanin-1 is a pantetheine hydrolase that plays key role in inflammatory diseases. Effective tools for noninvasive, real-time monitoring of are lacking, largely due to background fluorescence interference existing probes. To address this issue, we developed dual-modal fluorescent and colorimetric probe, MB-Van1, detect with high sensitivity selectivity. MB-Van1 has structure optimized exhibit nearly zero fluorescence, resulting signal-to-noise ratio enables the accurate detection activity various biological tissues. In vitro experiments demonstrated had limit as low 0.031 ng/mL mode. We successfully employ observe elevated levels tissues mouse models rheumatoid arthritis (RA), drug-induced liver injury (DILI), nonsteroidal anti-inflammatory drug (NSAID) enteropathy models, within only 5 min. This advancement provides novel approach dynamic changes during inflammation, offering new strategies early diagnosis therapeutic assessment other related
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
A new dual-channel and dual-functional fluorescent probe, DX3-AXI, is developed with the aid of computational chemistry, enabling viscosity SO2 detection in separate fluorescence emission channels. The probe DX3-AXI exhibits significant changes detection, demonstrating excellent interference resistance a linear response. Through Density Functional Theory (DFT) Time-Dependent (TDDFT) calculations, along hole–electron molecular analysis, energy level structure, local attachment mechanism response systematically revealed, that regulation interactions between rotatable bond double drives changes. Furthermore, portable sensing platform for on-site sulfite water samples was by coupling smartphone, rapid qualitative semiquantitative sulfite. Significantly, has demonstrated successful application detecting microenvironment normal cancer cells while also visualization variations liver tissue mice injury. shown potential disease diagnostics, drug assessment, environmental monitoring.
Language: Английский
Citations
1
Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: 466, P. 116385 - 116385
Published: March 10, 2025
Language: Английский
Citations
1
Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 457, P. 115881 - 115881
Published: July 9, 2024
A new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid sensitive detection of CN–, F−, OH– ions in THF, exhibiting ultra-low limits 26.26 nM, 43.05 8.64 respectively, through a turn-on fluorescent process. The seleno-funcionalization step novel methodology developed by our group, allowing direct functionalization BODIPY core. This procedure involves quick reaction utilizing Ph2Se2 as selenium source, BPO (benzoyl peroxide), p-TSA (p-toluenesulfonic acid) acetonitrile, enabling production corresponding chalcogenated BODIPYs containing one to four groups, demonstrating its versatility. structure 4 confirmed HRMS, 1H, 13C, 77Se NMR, IR spectra, photophysical properties were also evaluated. applied detect dual-mode (UV–Vis fluorescence spectra), displaying ratiometric response. probe exhibited fast response time, visual color change from blue yellow, high sensitivity selectivity these analytes over other selected anions. Mechanistic investigation mass analysis revealed that anions occurs via an Aromatic Nucleophilic Substitution with phenylselenide leaving group.
Language: Английский
Citations
8
Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 14, 2024
Diabetes is a chronic disease marked by high blood glucose. With the progress of diabetes, complications gradually appear, and various organs may be affected. However, due to lack noninvasive in situ detection probes, diagnosis organ damage caused diabetes significantly delayed, which will cause many that cannot treated time. Here, we report BODIPY-based fluorescent probe SNL, can used detect lung liver diabetes. By introducing methylpiperazine extending conjugated system, SNL locate lysosomes exhibit absorption emission both near-infrared (NIR) region. In addition, sensitive polarity for lysosomal changes. Unexpectedly, targets images lungs mice. Subsequently, hyperglycemia-stimulated cell models diabetic mouse were successfully established, was utilized reveal as diagnostic signal complications. Notably, first time confirmed injury using probes method, providing new approach
Language: Английский
Citations
7
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 322, P. 124846 - 124846
Published: July 18, 2024
Language: Английский
Citations
6
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(42), P. 16964 - 16970
Published: Oct. 8, 2024
Keloids represent pathologic conditions characterized by the presence of hyalinized collagen bundles and chronic inflammatory reactions. Recently, increased ROS production disrupted apoptosis mechanisms in keloids have been reported, although detailed remain unclear. Herein, we developed a specific fluorescence probe,
Language: Английский
Citations
4