ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11585 - 11636
Published: Oct. 11, 2024
Soft robotics presents innovative solutions across different scales. The flexibility and mechanical characteristics of soft robots make them particularly appealing for wearable implantable applications. scale level invasiveness required depend on the extent human interaction. This review provides a comprehensive overview robots, including applications in rehabilitation, assistance, organ simulation, surgical tools, therapy. We discuss challenges such as complexity fabrication processes, integration responsive materials, need robust control strategies, while focusing advances actuation sensing mechanisms, techniques. Finally, we future outlook, highlighting key proposing potential solutions.
Language: Английский
Citations
12
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101471 - 101471
Published: Jan. 11, 2025
Anisotropic scaffolds with unidirectionally aligned fibers present an optimal solution for nerve tissue engineering and graft repair. This study investigates the application of filamented light (FLight) biofabrication to create hydrogel matrices featuring highly microfilaments, facilitating neurite guidance outgrowth from encapsulated chicken dorsal root ganglion (DRG) cells. FLight employs optical modulation instability (OMI) rapidly safely (<5 s) fabricate constructs precise microfilament alignment. The tunability was demonstrated by adjusting four key parameters: stiffness, porosity, growth factor release, incorporation biological cues. Matrix stiffness fine-tuned varying projection dose, yielding ranging 0.6 5.7 kPa. Optimal occurred at a kPa, achieving 2.5 mm over 4 days. porosity modified using diffraction gratings in setup. While significant differences alignment were observed between bulk gels, further increases 40 % 70 enhanced cell migration axon bundling without significantly affecting maximal outgrowth. protein microcrystals containing (NGF) into photoresin enabled sustained need additional NGF media. Finally, laminin added resin enhance bioactivity biomaterial, resulting increase maximum 3.5 after days culture softer matrices. Overall, varied matrix properties achieved through outgrowth, highlighting importance adaptable scaffold characteristics guiding development. demonstrates potential as versatile platform creating ideal clinical applications repair engineering.
Language: Английский
Citations
1
Medical Review, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract Current two-dimensional (2D) cell models for effective drug screening suffer from significant limitations imposed by the lack of realism in physiological environment. Three-dimensional (3D) organoids hold immense potential mimicking key functions human organs overcoming traditional 2D models. However, current techniques preparation 3D had reproducibility, scalability, and ability to closely replicate complex microenvironment found vivo . Additionally, culture systems often involve lengthy labor-intensive processes that hinder high-throughput applications necessary a large-scale screening. Advancements bioprinting technologies offer promising solutions these challenges enabling precise spatial control over placement material composition, thereby facilitating creation more physiologically relevant than techniques. This review provides comprehensive summary recent advances creating models, which begins with an introduction different types (especially focus on volumetric (VBP) technique), followed overview bioinks utilized bioprinting. Moreover, we also introduce disease efficiency evaluation regenerative medicine. Finally, possible strategies development clinical translation are concluded.
Language: Английский
Citations
0
Supramolecular Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100100 - 100100
Published: Feb. 1, 2025
Language: Английский
Citations
0
Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Language: Английский
Citations
0
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Skeletal muscle's elegant protein-based architecture powers motion throughout the animal kingdom, with its constituent actomyosin complexes driving intra- and extra-cellular motion. Classical motors recently developed soft actuators cannot match packing density contractility of individual muscle fibers that scale to power ants elephants alike. Accordingly, interdisciplinary fields robotics tissue engineering have combined efforts build living can a new class robots be more energy-efficient, dexterous, safe than existing motor-powered hydraulic paradigms. Doing so ethically at scale─creating meter-scale constructs from sustainable progenitor cell lines─has inspired innovations in biomaterials culture methodology. We weave discussions biology, materials chemistry, engineering, biohybrid design review state art actuator biofabrication. Looking forward, we outline vision for robotic systems tie recent progress long-term research goals.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Abstract Biomimetic materials hold significant potential for a wide range of applications, yet developing straightforward and versatile methods to create muscle‐mimetic, high‐performance protein with anisotropic properties remains major challenge. In this study, simple general strategy is presented alignment driven by directional airflow, enabling the design printable, muscle‐mimetic proteins. By utilizing airflow during hydrogel drying in combination rapid photochemistry, molecules align efficiently single direction. Similar natural muscle, mechanical these can be further enhanced through training, achieving remarkable strength up ≈8 MPa at 600% strain an anisotropy factor 3.0. This fabrication process compatible conventional printing techniques, allowing creation complex structures controlled tailored properties. Notably, exhibit biomimetic actuation (≈6 s) adaptability under physiological conditions. Their demonstrated proof‐of‐concept applications as artificial grippers vessel dilators, which remain stable months but degrade rapidly within hours after enzymatic treatment post‐therapy. directional‐airflow‐driven method, along resulting materials, offers promising implications fields, from medical devices adaptive technologies.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Designing tissue-specific bioinks to replicate actual tissue environments and desired biomechanical properties.
Language: Английский
Citations
3
RSC Advances, Journal Year: 2024, Volume and Issue: 14(37), P. 27424 - 27437
Published: Jan. 1, 2024
Despite its effectiveness in managing the motor symptoms of Parkinson's disease, levodopa therapy is often accompanied by adverse effects that can significantly reduce patients' quality life. Hence, need to detect has escalated among researchers and health experts. Herein, intricacies adsorption were studied using newly tailored fullerene-based adsorbents. All theoretical calculations performed DFT/PBE1PBE/GENECP level theory. Having modified surface Pt-encapsulation followed functionalization with a functional group (COOH, HCO, NH
Language: Английский
Citations
2
ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Citations
0