Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

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Amphiphilic quinoline-malononitrile AIE probes: From molecule design to bio-applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216550 - 216550

Published: Feb. 24, 2025

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Aggregation-induced emission materials-based Electrochemiluminescence emitters for sensing applications: Progress, challenges and perspectives

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216520 - 216520

Published: Feb. 12, 2025

Language: Английский

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Gel-to-Coacervate Transition in Peptide/HA Complexes for MMP-9-Activated Penetration into Tumor Spheroids

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Short phase-separating peptides serve as liquid-based vehicles due to their remarkable fluidity and cell permeability, holding great promise in diffusion-limited applications such intracellular drug delivery or penetration into deep-seated tumors. However, tuning the phase stability phase-transition sensitivity of these coacervates response specific pathological signals remains a significant challenge. To tackle this challenge, study presents peptide/hyaluronic acid (HA) complex coacervate system, which undergoes solid-to-coacervate transition upon exposure matrix metalloproteinase 9 (MMP-9). By harnessing disease-relevant enzyme, overexpressed ovarian tumor microenvironment, we further demonstrate improved infiltration Hey cells spheroids. These observations highlight feasibility modulating behaviors advanced functions through sequence-specific monomer design, offering practical strategy for on-target medicine

Language: Английский

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Top-down bioinspired nanotheranostics with AIE luminogens

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216681 - 216681

Published: April 15, 2025

Language: Английский

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Low-background Near-infrared Fluorescent Probe for Real-time Monitoring of β-Glucuronidase Activity in Inflammation and Therapy

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

β-Glucuronidase (GUS) is an acidic hydrolase enzyme overexpressed in various inflammatory diseases, making it a promising biomarker for inflammation. However, current tools real-time, situ imaging of GUS activity are hindered by background interference, which reduces their effectiveness dynamic biological environments. To address this challenge, we developed Ox-GUS, GUS-specific fluorescent probe with unique molecular design featuring disrupted conjugated structure. This provided Ox-GUS near-zero optical properties, significantly enhanced signal-to-noise ratio, and highly sensitive detection ability. The demonstrated fluorescence enhancement up to 400 folds response activity, limit as low 0.0035 U/mL. We successfully employed visualize real-time mouse models rheumatoid arthritis, autoimmune hepatitis, bowel disease, effectively monitored therapeutic responses. study highlights the potential robust tool advancing research on GUS-related mechanisms early diagnosis treatment monitoring diseases.

Language: Английский

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Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 119, P. 118081 - 118081

Published: Jan. 23, 2025

Language: Английский

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A π-Extended AIE Platform for Pattern Recognition of Glycosaminoglycans

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Accurate discrimination of complicated glycosaminoglycans is a challenging but meaningful task for ensuring their safe use in clinics. With the purpose reducing production cost sensor arrays glycosaminoglycans, three fluorescence turn-on sensors named TPPEBA, TPPEMe, and TPPEC7 were readily synthesized by simple alkylation pyridyl units π-extended AIEgen, namely, tetra-(4-pyridylphenyl) ethylene. The designed are cross-reactive toward tested including heparin, chondroitin sulfate, hyaluronic acid, dextran whose mechanism could be ascribed to multivalent electrostatic, CH···π, hydrophobic interactions between different form corresponding fluorescent aggregates. afforded three-component array TPPE-SA powerful wide concentration range 1-200 μg/mL. Hierarchical clustering analysis linear discriminant results indicated that can successfully applied accurate detecting trace glycosaminoglycan contaminants heparin monitoring diluted serum samples with almost 100% accuracy.

Language: Английский

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Eradication of Antibiotic-Resistant Gram-Positive Bacteria and Biofilms by Rationally Designed AIE-Active Iridium(III) Complexes Derived from Cyclometalating 2-Phenylquinoline and Ancillary Bipyridyl Ligands

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: 64(6), P. 2905 - 2918

Published: Jan. 31, 2025

Antibiotic resistance caused by Gram-positive bacteria is a growing global human health threat. Selective discrimination and eradication of their biofilms challenging. Therapeutic strategies with multiple modes action are urgently needed to address the increase in bacteria-resistant nosocomial infections. In this work, we have presented rationally designed aggregation-induced emission (AIE)-active cationic cyclometalated iridium(III) complexes derived from 2-phenylquinoline 2,2'-bipyridine ligands for antibacterial studies. The AIE properties these were exploited selective between Gram-negative bacteria. These displayed good antimicrobial activity against critical ESKAPE pathogens minimum inhibitory concentrations low micromolar range but inactive pathogens. Importantly, can inhibit biofilm formation eradicate mature biofilms, which major causes persistent infections antibiotic more difficult eliminate. addition, showed hemolytic mammalian cells high therapeutic index, indicating selectivity. Interestingly, kill through variety mechanism, including ROS generation, cell membrane disruption, depolarization loss bacterial integrity. findings offer opportunities designing metal AIEgens treat effectively.

Language: Английский

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Tuning the Chain Conformation of Pyrenyl-Pyridine Conjugated Oligomer Nanoprobe for Ultrasensitive Fluorescent Assaying of Fe3+ and Ascorbic Acid

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

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