Journal of Agricultural and Food Chemistry,
Journal Year:
2018,
Volume and Issue:
66(34), P. 8914 - 8934
Published: July 31, 2018
Pd-catalyzed
cross-coupling
reactions
have
become
essential
tools
for
the
construction
of
carbon–carbon
and
carbon–heteroatom
bonds.
Over
last
three
decades,
great
efforts
been
made
with
chemistry
in
discovery,
development,
commercialization
innovative
new
pharmaceuticals
agrochemicals
(mainly
herbicides,
fungicides,
insecticides).
In
view
growing
interest
both
modern
crop
protection
chemistry,
this
review
gives
a
comprehensive
overview
successful
applications
various
methodologies,
which
implemented
as
key
steps
synthesis
(on
R&D
pilot-plant
scales)
such
Heck,
Suzuki,
Sonogashira,
Stille,
Negishi
reactions,
well
decarboxylative,
carbonylative,
α-arylative,
carbon–nitrogen
bond
bond-forming
reactions.
Some
perspectives
challenges
these
catalytic
coupling
processes
discovery
are
briefly
discussed
final
section.
The
examples
chosen
demonstrate
that
approaches
open-up
new,
low-cost,
more
efficient
industrial
routes
to
existing
agrochemicals,
methods
also
capability
lead
generation
pesticides
novel
modes
action
sustainable
protection.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
119(4), P. 2192 - 2452
Published: Nov. 27, 2018
C–H
activation
has
surfaced
as
an
increasingly
powerful
tool
for
molecular
sciences,
with
notable
applications
to
material
crop
protection,
drug
discovery,
and
pharmaceutical
industries,
among
others.
Despite
major
advances,
the
vast
majority
of
these
functionalizations
required
precious
4d
or
5d
transition
metal
catalysts.
Given
cost-effective
sustainable
nature
earth-abundant
first
row
metals,
development
less
toxic,
inexpensive
3d
catalysts
gained
considerable
recent
momentum
a
significantly
more
environmentally-benign
economically-attractive
alternative.
Herein,
we
provide
comprehensive
overview
on
until
summer
2018.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 1485 - 1542
Published: Nov. 18, 2021
The
merger
of
photoredox
catalysis
with
transition
metal
catalysis,
termed
metallaphotoredox
has
become
a
mainstay
in
synthetic
methodology
over
the
past
decade.
Metallaphotoredox
combined
unparalleled
capacity
for
bond
formation
broad
utility
photoinduced
electron-
and
energy-transfer
processes.
Photocatalytic
substrate
activation
allowed
engagement
simple
starting
materials
metal-mediated
bond-forming
Moreover,
electron
or
energy
transfer
directly
key
organometallic
intermediates
provided
novel
modes
entirely
complementary
to
traditional
catalytic
platforms.
This
Review
details
contextualizes
advancements
molecule
construction
brought
forth
by
metallaphotocatalysis.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
118(4), P. 2249 - 2295
Published: Feb. 20, 2018
Cross-couplings
and
related
reactions
are
a
class
of
highly
efficient
synthetic
protocols
that
generally
promoted
by
molecular
Pd
species
as
catalysts.
However,
catalysts
based
on
more
or
less
dispersed
metal
have
been
also
employed
for
this
purpose,
their
use,
which
was
largely
limited
to
the
Heck
reaction
until
turn
century,
has
extended
in
recent
years
most
class.
This
review
provides
critical
overview
these
applications
Particular
attention
is
devoted
discussion
mechanistic
pathways
proposed
explain
catalytic
role
metal.
Furthermore,
outstanding
systems
emerged
illustrated,
together
with
development
novel
approaches
boost
reactivity
A
section
summarizing
current
industrial
catalyzed
kind
concludes
review.
Science,
Journal Year:
2018,
Volume and Issue:
360(6385), P. 186 - 190
Published: Feb. 15, 2018
A
guide
for
catalyst
choice
in
the
forest
Chemists
often
discover
reactions
by
applying
catalysts
to
a
series
of
simple
compounds.
Tweaking
those
tolerate
more
structural
complexity
pharmaceutical
research
is
time-consuming.
Ahneman
et
al.
report
that
machine
learning
can
help.
Using
high-throughput
data
set,
they
trained
random
algorithm
predict
which
specific
palladium
would
best
isoxazoles
(cyclic
structures
with
an
N–O
bond)
during
C–N
bond
formation.
The
predictions
also
helped
analysis
inhibition
mechanism.
Science
,
this
issue
p.
186
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
47(15), P. 5786 - 5865
Published: Jan. 1, 2018
This
review
provides
an
overview
of
the
use
electrochemistry
as
appealing
platform
for
expediting
carbon–hydrogen
functionalization
and
carbon–nitrogen
bond
formation.
Accounts of Chemical Research,
Journal Year:
2020,
Volume and Issue:
53(3), P. 547 - 560
Published: Feb. 20, 2020
Electrochemistry
has
been
used
as
a
tool
to
drive
chemical
reactions
for
over
two
centuries.
With
the
help
of
an
electrode
and
power
source,
chemists
are
bestowed
with
imaginary
reagent
whose
potential
can
be
precisely
dialed
in.
The
theoretically
infinite
redox
range
renders
electrochemistry
capable
oxidizing
or
reducing
some
most
tenacious
compounds
(e.g.,
F
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2752 - 2906
Published: Aug. 10, 2021
Photoinduced
chemical
transformations
have
received
in
recent
years
a
tremendous
amount
of
attention,
providing
plethora
opportunities
to
synthetic
organic
chemists.
However,
performing
photochemical
transformation
can
be
quite
challenge
because
various
issues
related
the
delivery
photons.
These
challenges
barred
widespread
adoption
steps
industry.
past
decade,
several
technological
innovations
led
more
reproducible,
selective,
and
scalable
photoinduced
reactions.
Herein,
we
provide
comprehensive
overview
these
exciting
advances,
including
flow
chemistry,
high-throughput
experimentation,
reactor
design
scale-up,
combination
photo-
electro-chemistry.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(17), P. 3981 - 3981
Published: Sept. 1, 2020
Although
chitin
is
of
the
most
available
biopolymers
on
Earth
its
uses
and
applications
are
limited
due
to
low
solubility.
The
deacetylation
leads
chitosan.
This
biopolymer,
composed
randomly
distributed
β-(1-4)-linked
D-units,
has
better
physicochemical
properties
facts
that
it
possible
dissolve
this
biopolymer
under
acidic
conditions,
can
adopt
several
conformations
or
structures
be
functionalized
with
a
wide
range
functional
groups
modulate
superficial
composition
specific
application.
Chitosan
considered
highly
biocompatible
biodegradability,
bioadhesivity
bioactivity
in
such
way
displays
applications.
Thus,
chitosan
promising
for
numerous
biomedical
field
(skin,
bone,
tissue
engineering,
artificial
kidneys,
nerves,
livers,
wound
healing).
also
employed
trap
both
organic
compounds
dyes
selective
separation
binary
mixtures.
In
addition,
used
as
catalyst
starting
molecule
obtain
high
added
value
products.
Considering
these
premises,
review
focused
structure
modification
well
Science,
Journal Year:
2019,
Volume and Issue:
363(6424)
Published: Jan. 18, 2019
Synthetic
innovation
in
drug
development
Chemical
synthesis
plays
a
key
role
pharmaceutical
research
and
development.
Campos
et
al.
review
some
of
the
advantages
that
have
come
from
recent
innovations
synthetic
methods.
In
particular,
they
highlight
small-molecule
catalysts
stimulated
by
visible
light,
enzymes
engineered
for
versatility
beyond
their
intrinsic
function,
bio-orthogonal
reactions
to
selectively
modify
proteins
conjugation.
High-throughput
techniques
are
also
poised
accelerate
methods
optimization
small-scale
discovery
large-scale
production,
complementary
machine-learning
approaches
just
coming
into
focus.
Science
,
this
issue
p.
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