DNA origami

Nature Reviews Methods Primers, Journal Year: 2021, Volume and Issue: 1(1)

Published: Jan. 28, 2021

Language: Английский

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Biotechnological mass production of DNA origami

Nature, Journal Year: 2017, Volume and Issue: 552(7683), P. 84 - 87

Published: Dec. 6, 2017

Language: Английский

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DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(17), P. 9420 - 9481

Published: July 16, 2020

DNA is traditionally known as a central genetic biomolecule in living systems. From an alternative perspective, versatile molecular building-block for the construction of functional materials, particular biomaterials, due to its intrinsic biological attributes, recognition capability, sequence programmability, and biocompatibility. The topologies building-blocks mainly include linear, circular, branched types. Branched recently has been extensively employed synthesize new assortment promising applications have explored. In this review, we discuss progress on materials assembled from DNA. We first briefly introduce background information molecules sketch development history constructed second part, synthetic strategies are categorized into base-pairing assembly chemical bonding. third DNA-based comprehensively summarized including tile-mediated assembly, origami, dynamic hybrid assembly. fourth diagnostics, protein engineering, drug gene delivery, therapeutics, cell engineering demonstrated. end, insight challenges future perspectives provided. envision that can not only enrich nanotechnology by ingenious design synthesis but also promote interdisciplinary fields chemistry, biology, medicine, ultimately addressing growing demands medical-related real world.

Language: Английский

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Chemistries for DNA Nanotechnology

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(10), P. 6384 - 6458

Published: Feb. 4, 2019

The predictable nature of DNA interactions enables the programmable assembly highly advanced 2D and 3D structures nanoscale dimensions. access to ever larger more complex has been achieved through decades work on developing structural design principles. Concurrently, an increased focus emerged applications nanostructures. In its nature, is chemically inert nanostructures based unmodified mostly lack function. However, functionality can be obtained chemical modification opportunities are endless. this review, we discuss methodology for functionalization provide examples how being used create functional nanodevices make applicable. We aim encourage researchers adopt modifications as part their in nanotechnology inspire chemists address current challenges within field.

Language: Английский

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Colloidal Self-Assembly Approaches to Smart Nanostructured Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 4976 - 5067

Published: Nov. 8, 2021

Colloidal self-assembly refers to a solution-processed assembly of nanometer-/micrometer-sized, well-dispersed particles into secondary structures, whose collective properties are controlled by not only nanoparticle property but also the superstructure symmetry, orientation, phase, and dimension. This combination characteristics makes colloidal superstructures highly susceptible remote stimuli or local environmental changes, representing prominent platform for developing stimuli-responsive materials smart devices. Chemists achieving even more delicate control over their active responses various practical stimuli, setting stage ready fully exploiting potential this unique set materials. review addresses colloids nanostructured We first delineate driven forces different length scales. A concepts equations outlined controlling crystal growth, appreciating importance particle connectivity in creating responsive superstructures. then present working mechanisms strategies engineering assemblies. The underpinning separation systematically introduced, allowing tuning precise prediction response external stimuli. Various exciting applications these summarized with specific focus on structure-property correlation functional conclude summary existing challenges provide perspective further advances next generation.

Language: Английский

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Protocells and RNA Self-Replication

Cold Spring Harbor Perspectives in Biology, Journal Year: 2018, Volume and Issue: 10(9), P. a034801 - a034801

Published: Sept. 1, 2018

The general notion of an "RNA world" is that, in the early development life on Earth, genetic continuity was assured by replication RNA, and RNA molecules were chief agents catalytic function. Assuming that all components available some prebiotic locale, these could have assembled into activated nucleotides condensed to form polymers, setting stage for chemical polynucleotides through RNA-templated polymerization. If a sufficient diversity RNAs be copied with reasonable rate fidelity, then Darwinian evolution would begin facilitated their own reproduction enjoying selective advantage. concept "protocell" refers compartment where primitive material took place catalysts gave rise products accumulated locally benefit replicating cellular entity. Replication both protocell its encapsulated enabled natural selection operate based differential fitness competing entities, ultimately giving modern life.

Language: Английский

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Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

Nature Chemistry, Journal Year: 2019, Volume and Issue: 12(1), P. 26 - 35

Published: Nov. 25, 2019

Language: Английский

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Nuclease resistance of DNA nanostructures

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(4), P. 225 - 239

Published: Feb. 10, 2021

Language: Английский

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Rationally Engineered Nucleic Acid Architectures for Biosensing Applications

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(22), P. 11631 - 11717

Published: Oct. 1, 2019

Development of biosensing platforms plays a key role in research settings for identification biomarkers and clinical applications diagnostics. Biosensors based on nucleic acids have taken many forms, from simple duplex-based constructs to stimuli-responsive acid nanostructures. In this review, we look at various acid-based biosensors, the different read-out strategies employed, their use chemical biological sensing. We also current developments DNA nanotechnology-based biosensors how rational design such leads more efficient platforms.

Language: Английский

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Emerging 2D nanomaterials for biomedical applications

Materials Today, Journal Year: 2021, Volume and Issue: 50, P. 276 - 302

Published: June 17, 2021

Language: Английский

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