Nuclease resistance of DNA nanostructures

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(4), P. 225 - 239

Published: Feb. 10, 2021

Language: Английский

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Application of Zero-Dimensional Nanomaterials in Biosensing

Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 8

Published: April 17, 2020

Zero-dimensional (0D) nanomaterials, including graphene quantum dots (GQDs), carbon (CQDs), fullerenes, inorganic (QDs), magnetic nanoparticles (MNPs), noble metal nanoparticles, upconversion (UCNPs) and polymer (Pdots), have attracted extensive research interest in the field of biosensing recent years. Benefiting from ultra-small size, confinement effect, excellent physical chemical properties good biocompatibility, 0D nanomaterials shown great potential ion detection, biomolecular recognition, disease diagnosis pathogen detection. Here we first introduce structures different nanomaterials. On this basis, progress application examples are discussed. In last part, summarize status anticipate development prospects future challenges field.

Language: Английский

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DNA-Tetrahedral-Nanostructure-Based Entropy-Driven Amplifier for High-Performance Photoelectrochemical Biosensing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(1), P. 1710 - 1717

Published: Jan. 13, 2021

In virtue of the inherent molecular recognition and programmability, DNA has recently become most promising for high-performance biosensors. The rationally engineered nucleic acid architecture will be very advantageous to hybridization efficiency, specificity, sensitivity. Herein, a robust split-mode photoelectrochemical (PEC) biosensor miRNA-196a was developed based on an entropy-driven tetrahedral (EDTD) amplifier coupled with superparamagnetic nanostructures. tetrahedron structure features in rigidity structural stability that contribute obtain precise identification units specific orientations, improving sensitivity, selectivity as-designed PEC biosensor. Further, Fe3O4@SiO2@CdS particles integrated nanostructures are beneficial construction split-mode, highly selective, reliable Particularly, enzyme- hairpin-free EDTD eliminates unnecessary interference from complex secondary pseudoknots or kissing loops typical hairpin DNAs, significantly lowers background noise, improves detection This is capable monitoring practical settings additional advantages efficient electrode fabrication, stability, reproducibility. strategy can extended various miRNA assays biological systems excellent performance.

Language: Английский

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A review of aptamer-based SERS biosensors: Design strategies and applications

Talanta, Journal Year: 2021, Volume and Issue: 227, P. 122188 - 122188

Published: Feb. 6, 2021

Language: Английский

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CRISPR/Cas12a-based technology: A powerful tool for biosensing in food safety

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 122, P. 211 - 222

Published: March 1, 2022

Language: Английский

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Molecular convolutional neural networks with DNA regulatory circuits

Nature Machine Intelligence, Journal Year: 2022, Volume and Issue: 4(7), P. 625 - 635

Published: July 4, 2022

Language: Английский

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Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs

Laser & Photonics Review, Journal Year: 2024, Volume and Issue: 18(10)

Published: May 1, 2024

Abstract Early lung cancer screening by computed tomography is hampered pulmonary nodules caused massive COVID‐19 infections, necessitating an ultrasensitive approach for the early diagnosis of cancers at single‐base level from circular tumor DNAs (ctDNAs). This study introduces that merges DNA origami and scissors technologies in a framework surface plasmon resonance (SPR) biosensors. By combining precision probes with inherent resolution scissors, this method systematically addresses limitations conventional SPR techniques, resulting enhanced detection accuracy. The synergistic interplay between enables biosensors to achieve unprecedented levels sensitivity, precision, practical utility. efficacy allows precise identification mutations, demonstrated here T790M mutation EGFR gene G12C KRAS non‐small cell patients. With technique, as well near zeptomolar‐level sensitivity achieved. As result, discovery holds significant potential advance field diagnostics.

Language: Английский

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Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Small, Journal Year: 2023, Volume and Issue: 20(14)

Published: Nov. 20, 2023

Abstract Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview mechanisms and extensive practical applications nanozymes First, definition characteristics are introduced, emphasizing their significant role constructing efficient sensors. Subsequently, several common categories nanozyme materials delved into, including metal‐based, carbon‐based, metal‐organic framework, layered double hydroxide nanostructures, discussing Regarding mechanisms, two key roles particularly focused biosensors: selective enhancement signal amplification, which crucially support sensor performance. In terms applications, widespread use nanozyme‐based biosensors showcased various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into future development is provided, encompassing improvements optimizations design integration, expansion application fields through interdisciplinary collaboration. conclusion, this systematically presents biosensors, offering valuable references prospects research field.

Language: Английский

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Wearable and Implantable Cortisol‐Sensing Electronics for Stress Monitoring

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: March 14, 2023

Abstract Cortisol is a steroid hormone that released from the body in response to stress. Although moderate level of cortisol secretion can help maintain homeostasis, excessive cause various diseases, such as depression and anxiety. Conventional methods for measurement undergo procedures limit continuous monitoring, typically collecting samples bodily fluids, followed by separate analysis laboratory setting takes several hours. Thus, recent studies demonstrate wearable, miniaturized sensors integrated with electronic modules enable wireless real‐time analysis. Here, primary focus on wearable implantable devices continuously measure concentration. Diverse types cortisol‐sensing techniques, antibody‐, DNA‐aptamer‐, molecularly imprinted polymer‐based sensors, well aim monitor minimally invasive fashion are discussed. In addition monitors directly stress levels, other schemes indirectly stress, electrophysiological signals sweat also summarized. Finally, challenges future directions monitoring management electronics reviewed.

Language: Английский

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Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 159, P. 116931 - 116931

Published: Jan. 11, 2023

Language: Английский

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