Naturally-derived biopolymer nanocomposites: Interfacial design, properties and emerging applications

Materials Science and Engineering R Reports, Journal Year: 2018, Volume and Issue: 125, P. 1 - 41

Published: Feb. 23, 2018

Language: Английский

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Sequence-programmable covalent bonding of designed DNA assemblies

Science Advances, Journal Year: 2018, Volume and Issue: 4(8)

Published: Aug. 3, 2018

Bottom-up fabrication of custom nanostructures using the methods DNA nanotechnology has great potential for applications in many areas science and technology. One obstacle to concerns constrained environmental conditions at which objects retain their structure. We present a general, site-selective, scalable method creating additional covalent bonds that increase structural stability nanostructures. Placement thymidines close proximity within allows rational creation sites cyclobutane pyrimidine dimer (CPD) induced via ultraviolet irradiation. The may be used sequence-programmable fashion link free strand termini, bridge breaks crossover sites, create interhelical connections. Thus designed multilayer origami can remain stable temperatures up 90°C pure double-distilled water with no cations present. In addition, these show enhanced resistance against nuclease activity. Cryo-electron microscopy (cryo-EM) analysis non-cross-linked cross-linked indicated global shape internal network crossovers are preserved after A cryo-EM map CPD-stabilized object determined physiological ionic strength reveals substantial swelling behavior, presumably caused by repulsive electrostatic forces that, without stabilization, would cause disassembly low strength. Our opens new avenues wider range conditions.

Language: Английский

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Challenges and Perspectives of DNA Nanostructures in Biomedicine

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(37), P. 15818 - 15833

Published: Feb. 29, 2020

DNA nanotechnology holds substantial promise for future biomedical engineering and the development of novel therapies diagnostic assays. The subnanometer-level addressability nanostructures allows their precise tailored modification with numerous chemical biological entities, which makes them fit to serve as accurate tools multifunctional carriers targeted drug delivery. absolute control over shape, size, function enables fabrication dynamic devices, such nanorobots that can execute programmed tasks react various external stimuli. Even though several studies have demonstrated successful operation both in vitro vivo, major obstacles remain on path real-world applications DNA-based nanomedicine. Here, we summarize current status field main implementations nanostructures. In particular, focus open challenges untackled issues discuss possible solutions.

Language: Английский

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The biological applications of DNA nanomaterials: current challenges and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Oct. 8, 2021

Abstract DNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology the past decades, including tissue regeneration, disease prevention, inflammation inhibition, bioimaging, biosensing, diagnosis, antitumor drug delivery, and therapeutics. With rapid progress nanotechnology, multitudinous nanomaterials have designed with shape size based on classic Watson–Crick base-pairing molecular self-assembly. Some materials could functionally change cell behaviors, such migration, proliferation, differentiation, autophagy, anti-inflammatory effects. single-stranded DNAs (ssDNAs) or RNAs secondary structures via self-pairing, named aptamer, possess ability of targeting, which are selected systematic evolution ligands exponential enrichment (SELEX) applied tumor targeted diagnosis treatment. three-dimensional (3D) nanostructures stable investigated carrier systems to delivery multiple medicine gene therapeutic agents. While functional promoted development innovative designs preparation strategies, also proved great potential medical use, there is still long way go eventual application real life. Here this review, we conducted comprehensive survey structural history nanomaterials, introduced principles summarized their fields, discussed current challenges further that help achieve future.

Language: Английский

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Molecular Imprinting: Materials Nanoarchitectonics with Molecular Information

Bulletin of the Chemical Society of Japan, Journal Year: 2018, Volume and Issue: 91(7), P. 1075 - 1111

Published: April 13, 2018

Abstract Combining nanotechnology with other science disciplines is necessary to produce various materials nanoscale structural and functional information, which nanoarchitectonics, a novel paradigm create useful materials. One of the basic ideas in nanoarchitectonics use molecular-level information structurally design This strategy indeed used some existing fields technical realms. For example, molecular imprinting techniques provide possessing inside fabricated Revisiting this idea concept would have great meaning toward unification individual research into one key approach. In review, we survey fundamentals recent trends consideration nanoarchitectonics. Here, aspects examples are surveyed from advanced applications: (i) fundamental preparation polymers form nanoparticles, nanofibers, thin films, monolayers; (ii) surface coverage, post-modification, introduction new groups; (iii) imprinted controllable guest binding by external stimuli such as photo-responsive, temperature-sensitive, pH-sensitive, solvent-dependent, multi-stimuli responsive materials; (iv) using proteins template protein stamping; (v) cyclodextrins monomers; (vi) functions including highly sensitive selective sensors combined DNA aptamers enzymatic reactions, post-imprinting for sophisticated sensors, applications drug delivery systems.

Language: Английский

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DNA Origami Route for Nanophotonics

ACS Photonics, Journal Year: 2018, Volume and Issue: 5(4), P. 1151 - 1163

Published: Feb. 12, 2018

The specificity and simplicity of the Watson–Crick base pair interactions make DNA one most versatile construction materials for creating nanoscale structures devices. Among several DNA-based approaches, origami technique excels in programmable self-assembly complex, arbitrary shaped with dimensions hundreds nanometers. Importantly, can be used as templates assembly functional components into three-dimensional high precision controlled stoichiometry. This is often beyond reach other nanofabrication techniques. In this Perspective, we highlight capability realization novel nanophotonic systems. First, introduce basic principles designing fabrication structures. Subsequently, review recent advances applications nanoplasmonics, single-molecule super-resolution fluorescent imaging, well hybrid photonic We conclude by outlining future prospects advanced systems tailored functionalities.

Language: Английский

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Functional surface microstructures inspired by nature – From adhesion and wetting principles to sustainable new devices

Progress in Materials Science, Journal Year: 2021, Volume and Issue: 120, P. 100823 - 100823

Published: May 26, 2021

In the course of evolution nature has arrived at startling materials solutions to ensure survival. Investigations into biological surfaces, ranging from plants, insects and geckos aquatic animals, have inspired design intricate surface patterns create useful functionalities. This paper reviews fundamental interaction mechanisms such micropatterns with liquids, solids, soft matter as skin for control wetting, self-cleaning, anti-fouling, adhesion, adherence, sensing. Compared conventional chemical strategies, paradigm micropatterning enables superior resource efficiency sustainability. Associated applications range water management robotics future health monitoring devices. We finally provide an overview relevant patterning methods appendix.

Language: Английский

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DNA Nanostructures at the Interface with Biology

Chem, Journal Year: 2018, Volume and Issue: 4(3), P. 495 - 521

Published: March 1, 2018

Language: Английский

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On the Stability of DNA Origami Nanostructures in Low‐Magnesium Buffers

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(30), P. 9470 - 9474

Published: May 25, 2018

Abstract DNA origami structures have great potential as functional platforms in various biomedical applications. Many applications, however, are incompatible with the high Mg 2+ concentrations commonly believed to be a prerequisite for maintaining integrity. Herein, we investigate stability low‐Mg buffers. is found crucially depend on availability of residual ions screening electrostatic repulsion. The presence EDTA and phosphate may thus facilitate denaturation by displacing from backbone reducing strength –DNA interaction, respectively. Most remarkably, these buffer dependencies affected superstructure. However, rationally selecting components considering superstructure‐dependent effects, structural integrity given nanostructure can maintained conventional buffers even at low‐micromolar range.

Language: Английский

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Protein Assembly by Design

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13701 - 13796

Published: Aug. 18, 2021

Proteins are nature's primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes such as photosystem II nitrogenase that drive biogeochemical cycles to cytoskeletal assemblies muscle fibers motion. Such natural systems have inspired extensive efforts in rational design artificial last two decades. As blocks, proteins highly complex, terms both their three-dimensional structures chemical compositions. To enable control over self-assembly complex molecules, scientists devised many creative strategies by combining tools principles experimental computational biophysics, supramolecular chemistry, inorganic materials science, polymer among others. Owing these innovative strategies, what started a purely structure-building exercise decades ago has, short order, led with unprecedented functions protein-based unusual properties. Our goal this review is give an overview exciting interdisciplinary area research, first outlining been controlling self-assembly, then describing diverse assemblies, finally highlighting emergent properties assemblies.

Language: Английский

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