Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 23, 2022
Annually,
400
Mt
of
plastics
are
produced
which
roughly
40%
is
discarded
within
a
year.
Current
plastic
waste
management
approaches
focus
on
applying
physical,
thermal,
and
chemical
treatments
polymers.
However,
these
methods
have
severe
limitations
leading
to
the
loss
valuable
materials
resources.
Another
major
drawback
rapid
accumulation
into
environment
causing
one
biggest
environmental
threats
twenty-first
century.
Therefore,
complement
current
novel
routes
toward
degradation
upcycling
need
be
developed.
Enzymatic
conversion
present
promising
approach
sustainable
recycling
building
blocks.
quest
for
enzymes
that
efficiently
operate
in
cost-effective,
large-scale
poses
many
challenges.
To
date,
wide
range
experimental
set-ups
has
been
reported,
cases
lacking
detailed
investigation
microbial
species
exhibiting
degrading
properties
as
well
their
corresponding
enzymes.
The
apparent
lack
consistent
compromises
necessary
discovery
In
this
review,
we
discuss
prospects
possibilities
efficient
enzymatic
degradation,
recycling,
plastics,
correlation
with
diversity
broad
utilization.
identification
optimization
compared
discussed.
We
framework
standardized
workflow,
allowing
transparent
future.
Journal of Medicinal Chemistry,
Journal Year:
2020,
Volume and Issue:
63(12), P. 6315 - 6386
Published: March 17, 2020
The
applications
of
fluorine
in
drug
design
continue
to
expand,
facilitated
by
an
improved
understanding
its
effects
on
physicochemical
properties
and
the
development
synthetic
methodologies
that
are
providing
access
new
fluorinated
motifs.
In
turn,
studies
molecules
deeper
insights
into
metabolic
pathways,
distribution,
disposition.
Despite
high
strength
C–F
bond,
departure
fluoride
from
intermediates
can
be
facile.
This
reactivity
has
been
leveraged
mechanism-based
enzyme
inhibitors
influenced
fate
compounds.
this
Perspective,
we
summarize
literature
associated
with
metabolism
molecules,
focusing
examples
where
presence
influences
profile.
These
have
revealed
potentially
problematic
outcomes
some
motifs
enhancing
our
how
should
deployed.
ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
8(12), P. 10964 - 10976
Published: Oct. 18, 2018
Enzymes
are
complex
biological
catalysts
and
critical
to
life.
Most
oxidations
of
chemicals
catalyzed
by
cytochrome
P450
(P450,
CYP)
enzymes,
which
generally
utilize
mixed-function
oxidase
stoichiometry,
utilizing
pyridine
nucleotides
as
electron
donors:
NAD(P)H
+
O2
R
→
NAD(P)+
RO
H2O
(where
is
a
carbon
substrate
an
oxidized
product).
The
catalysis
largely
understood
in
the
context
heme
iron-oxygen
referred
Compound
I,
formally
FeO3+,
whose
basis
was
peroxidase
chemistry.
Many
X-ray
crystal
structures
P450s
now
available
(≥
822
from
≥146
different
P450s)
have
helped
understanding
catalytic
specificity.
In
addition
hydroxylations,
catalyze
more
oxidations,
including
C-C
bond
formation
cleavage.
derived
directed
evolution
can
even
unusual
reactions,
e.g.
cyclopropanation.
Current
questions
under
investigation
include
potential
role
intermediate
0
(formally
FeIII-O2-)
some
roles
high-
low-spin
forms
mechanism
desaturation,
open
closed
catalysis,
extent
processivity
multi-step
accessory
protein
b5.
More
global
exactly
how
structure
drives
function,
prediction
multiple
conformations.
The Journal of Steroid Biochemistry and Molecular Biology,
Journal Year:
2019,
Volume and Issue:
194, P. 105439 - 105439
Published: July 27, 2019
Advances
in
technology
have
allowed
for
the
sensitive,
specific,
and
simultaneous
quantitative
profiling
of
steroid
precursors,
bioactive
steroids
inactive
metabolites,
facilitating
comprehensive
characterization
serum
urine
metabolomes.
The
quantification
panels
is
therefore
gaining
favor
over
single
marker
metabolites
clinical
research
laboratories.
However,
although
biochemical
pathways
biosynthesis
metabolism
hormones
are
now
well
defined,
a
gulf
still
exists
between
this
knowledge
its
application
to
measured
profiles.
In
review,
we
present
an
overview
hormone
by
liver
peripheral
tissues,
specifically
highlighting
linking
differentiating
A
brief
methodology
used
also
provided.
ACS Central Science,
Journal Year:
2021,
Volume and Issue:
7(1), P. 55 - 71
Published: Jan. 14, 2021
Biocatalysis,
using
defined
enzymes
for
organic
transformations,
has
become
a
common
tool
in
synthesis,
which
is
also
frequently
applied
industry.
The
generally
high
activity
and
outstanding
stereo-,
regio-,
chemoselectivity
observed
many
biotransformations
are
the
result
of
precise
control
reaction
active
site
biocatalyst.
This
achieved
by
exact
positioning
reagents
relative
to
each
other
fine-tuned
3D
environment,
specific
activating
interactions
between
protein,
subtle
movements
catalyst.
Enzyme
engineering
enables
one
adapt
catalyst
desired
process.
A
well-filled
biocatalytic
toolbox
ready
be
used
various
reactions.
Providing
nonnatural
conditions
evolving
biocatalysts
play
with
myriad
options
creating
novel
transformations
thereby
opening
new,
short
pathways
target
molecules.
Combining
several
pot
perform
reactions
concurrently
increases
efficiency
biocatalysis
even
further.
Chemical Society Reviews,
Journal Year:
2019,
Volume and Issue:
48(24), P. 5624 - 5657
Published: Jan. 1, 2019
Protoporphyrin
IX
iron
complex
(heme)
is
an
important
cofactor
for
oxygen
transfer,
storage,
activation,
and
electron
transfer
when
bound
to
the
heme
proteins
hemoglobin,
myoglobin,
cytochrome
P450
c,
respectively.
In
addition
these
prototypical
proteins,
there
are
emergent,
critical
roles
of
exchangeable/labile
in
signal
transduction.
Specifically,
it
has
been
shown
that
association/dissociation
to/from
heme-responsive
sensors
regulates
numerous
functions,
including
transcription,
DNA
binding,
microRNA
splicing,
translation,
protein
kinase
activity,
degradation,
K+
channel
function,
two-component
transduction,
many
other
functions.
this
review,
we
provide
a
comprehensive
overview
structure-function
relationships
describe
new,
additional
as
functional
inhibitors
activators.
order
complete
description
various
heme-bound
also
mention
novel
chemical
reaction
centre
aldoxime
dehydratase,
cis-trans
isomerase,
N-N
bond
formation,
hydrazine
formation
S-S
These
unprecedented
functions
should
be
interest
biological
chemists.
Insight
into
underlying
molecular
mechanisms
essential
understanding
new
role
physiological
pathological
processes.
Frontiers in Microbiology,
Journal Year:
2019,
Volume and Issue:
10
Published: Feb. 13, 2019
Bioremediation
is
the
degradation
potential
of
microorganisms
to
dissimilate
complex
chemical
compounds
from
surrounding
environment.
The
genetics
and
biochemistry
biodegradation
processes
in
datasets
opened
way
systems
biology.
Systemic
biology
aid
study
interacting
parts
involved
system.
significant
keys
system
are
network,
computational
biology,
omics
approaches.
Biodegradation
network
consists
all
databases
which
assisting
deterioration
for
bioremediation
processes.
This
review
deciphers
bio-degradation
i.e.,
(UM-BBD,
PAN,
PTID
etc.)
aiding
processes,
multi
approaches
like
metagenomics,
genomics,
transcriptomics,
proteomics
metabolomics
efficient
functional
gene
mining
their
validation
experiments.
Besides,
present
also
describes
editing
tools
CRISPR
Cas,
TALEN
ZFNs
can
possibly
make
design
microbe
with
interest
particular
recalcitrant
improved
bioremediation.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8067 - 8101
Published: Jan. 1, 2021
Molecular
oxygen
as
a
green,
inexpensive
oxidant
and
source
has
displayed
lots
of
advantages
compared
to
other
oxidants.
This
review
introduces
the
recent
advances
radical
processes
in
molecular
oxygen-mediated
oxygenation
reactions.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(15), P. 5310 - 5358
Published: Jan. 1, 2020
This
review
highlights
the
developments
in
iron
and
cobalt
catalyzed
C(sp3)–H
bond
functionalization
reactions
with
emphasis
on
their
applications
organic
synthesis,
i.e.
natural
products
pharmaceuticals
synthesis
and/or
modification.
