Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 77, P. 101619 - 101619

Published: April 5, 2022

Language: Английский

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Chiral Molecule-mediated Porous Cu_xO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

Journal of the American Chemical Society, Journal Year: 2018, Volume and Issue: 141(2), P. 1091 - 1099

Published: Dec. 12, 2018

Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform CuxO nanoparticle clusters (NCs) with an average size 65 ± 7 nm, using phenylalanine (Phe) as structure-directing agent. These NCs functionally mimicked activities peroxidase, superoxide dismutase, catalase, glutathione peroxidase. Because they eliminated ROS, inhibited neurotoxicity in a cellular model disease rescued memory loss mice The biocompatibility multiple enzyme-mimicking offer new opportunities for application biomedicine, biosensing, biocatalysis.

Language: Английский

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Single‐Atom Catalysts in Catalytic Biomedicine

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(8)

Published: Jan. 13, 2020

The intrinsic deficiencies of nanoparticle-initiated catalysis for biomedical applications promote the fast development alternative versatile theranostic modalities. catalytic performance and selectivity are critical issues that challenging to be augmented optimized in biological conditions. Single-atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one most explored biomedicine recently due their preeminent activity superior distinct from nanosized counterparts. Herein, an overview pivotal significance SACs some underlying need addressed is provided, with a specific focus on applications. Their fabrication strategies, surface engineering, structural characterizations discussed briefly. In particular, triggering representative reactions providing fundamentals use discussed. A sequence paradigms summarized successful construction varied (e.g., cancer treatment, wound disinfection, biosensing, oxidative-stress cytoprotection) emphasis uncovering mechanisms understanding structure–performance relationships. Finally, opportunities challenges faced future SACs-triggered outlooked.

Language: Английский

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Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

Neural Regeneration Research, Journal Year: 2021, Volume and Issue: 17(3), P. 543 - 543

Published: Aug. 20, 2021

Alzheimer's disease is a rather complex neurodegenerative disease, which attributed to combination of multiple factors. Among the many pathological pathways, synaptic dysfunctions, such as synapses loss and deficits in plasticity, were thought be strongly associated with cognitive decline. The deficiencies various sorts neurotransmissions are responsible for multifarious symptoms example, cholinergic glutamatergic decline, excitatory inhibitory neurotransmission dyshomeostasis plasticity epileptiform symptoms, monoamine neuropsychiatric symptoms. Amyloid cascade hypothesis most popular theory explain pathogenesis attracts considerable attention. Multiple lines genetic evidence support predominant role amyloid beta pathology. Neurofibrillary tangles assembled by microtubule-associated protein tau other important histopathological characteristics brains. Cascade toxicity was proved lead neuron damage, neuroinflammation oxidative stress brain. Ageing main risk factor diseases, inflammation, stress, reduced metabolism, endocrine insufficiencies organ failures. These aging related factors also some contributing disease. In drug development, good therapeutic strategies have been investigated clinical evaluations. However, mechanism interplay among different call come out all-powerful therapies curing functions. This review seeks summarize representative treatments targeting pathways currently under Multi-target an emerging strategy treatment will highlighted.

Language: Английский

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Recognition Moieties of Small Molecular Fluorescent Probes for Bioimaging of Enzymes

Accounts of Chemical Research, Journal Year: 2019, Volume and Issue: 52(7), P. 1892 - 1904

Published: June 20, 2019

Enzymes are a class of important substances for life, and their abnormal levels associated with many diseases. Thus, great progress has been made in the past decade detecting imaging enzymes living biosystems, this respect fluorescent probes combined confocal microscopy have attracted much attention because high sensitivity unrivaled spatiotemporal resolution. Fluorescent usually composed three moieties: signal or fluorophore moiety, recognition labeling an appropriate linker to connect two aforementioned moieties. At present, however, research reviews on enzymatic mostly focus fluorophores and/or linkers, whereas those moiety relatively few. Moreover, current some moieties drawbacks such as poor selectivity, background fluorescence, or/and low unsatisfactory practical applications. developing new higher specificity enzyme interest is very desirable but still challenging. In Account, we introduce several enzymes, including tyrosinase, monoamine oxidase A (MAO-A), nitroreductase (NTR), aminopeptidases. Highlights given how specific tyrosinase MAO-A were designed eliminate interference by reactive oxygen species (ROS) MAO-B, respectively. Here present four recent examples which employed image biosystems. The first example shows that 3-hydroxyphenyl can serve more than traditional 4-hydroxyphenyl group enabling development highly selective probe without ROS. second presents general design strategy enzyme, involves combining characteristic structure inhibitor target along its successfully demonstrates it detection presence isomeric MAO-B. third mainly illustrates 5-nitrothiophen-2-yl alcohol stronger electron-donating S atom better fluorescence quenching 5-nitrofuran-2-yl NTR, leading sensitive method NTR assay. Lastly, basis known observations, show besides interaction target, another function may be responsible tuning signal, exemplified linking aminopeptidases' free hydroxyl amino different fluorophores. It our wish Account will promote appearance excellent properties biofunctions uncovered.

Language: Английский

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Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 62(20), P. 8881 - 8914

Published: May 13, 2019

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation multiple targets may improve both therapeutic safety and efficacy, compared with drugs. However, few multitarget are on market or in clinical trials, despite best efforts medicinal chemists. This article discusses systematic establishment target combination, lead generation, optimization multitarget-directed ligands (MTDLs). Moreover, we analyze some MTDLs research cases for several complex diseases recent years physicochemical properties 117 drugs, aim reveal trends insights potential use MTDLs.

Language: Английский

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A Perspective on Multi-target Drugs for Alzheimer’s Disease

Trends in Pharmacological Sciences, Journal Year: 2020, Volume and Issue: 41(7), P. 434 - 445

Published: May 21, 2020

Language: Английский

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Fluorescent probes for the detection of disease-associated biomarkers

Science Bulletin, Journal Year: 2022, Volume and Issue: 67(8), P. 853 - 878

Published: Jan. 17, 2022

Language: Английский

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