Visualizing Peroxynitrite in Microvessels of the Brain with Stroke Using an Engineered Highly Specific Fluorescent Probe

ACS Sensors, Journal Year: 2020, Volume and Issue: 5(10), P. 3237 - 3245

Published: Oct. 14, 2020

Stroke is one of the leading causes death and disability in world, which associated with malfunction reactive oxygen species nitrogen (ROS/RNS) cerebral microvessels. In vivo monitoring these species, such as ONOO–, high selectivity stroke process great significance for early diagnoses therapies disease. Herein, by engineering an indoline-2,3-dione moiety recognizing domain, we proposed a novel fluorescence probe Rd-PN2 highly specific response toward even coexistence other ROS/RNS concentration. showed sensitivity reaction speed to ONOO– exhibited satisfying performances tracking endogenously generated living cells zebrafish. Accordingly, can furnish real-time visualizing microvessels mice ischemic hemorrhagic strokes under two-photon microscopy. This work presented precisely modulated production micovessels, will also help acquire more accurate information studies functions future.

Language: Английский

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Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(21), P. 11766 - 11784

Published: Jan. 1, 2021

This tutorial review summarizes the recent advances of in situ molecular immobilization strategies and utilization these for bioimaging therapeutics.

Language: Английский

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Recent Advances in Fluorescent Probes for Detection of HOCl and HNO

ACS Omega, Journal Year: 2020, Volume and Issue: 5(4), P. 1730 - 1742

Published: Jan. 21, 2020

It is known that reactive oxygen (ROS) and nitrogen (RNS) species play a diverse role in various biological processes, such as inflammation, signal transduction, neurodegenerative injury, apart from causing diseases caused by oxidative nitrosative stresses, respectively, ROS RNS. Thus, it very important to quantify the concentration level of RNS live cells, tissues, organisms. Various small-molecule-based fluorescent/chemodosimetric probes are reported map effective distribution ROS/RNS under vitro/in vivo conditions with great spatial temporal resolution. Such reagents now appreciated an excellent tool for aiding breakthroughs modern redox biology. This mini-review brief, but all-inclusive, account molecular have been developed recently.

Language: Английский

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Light-emitting self-assembled metallacages

National Science Review, Journal Year: 2021, Volume and Issue: 8(6)

Published: March 15, 2021

Abstract Coordination-driven self-assembly of metallacages has garnered significant interest because their 3D layout and cavity-cored nature. The well-defined, highly tunable metallacage structures render them particularly attractive for investigating the properties luminophores, as well inducing novel photophysical characters that enable widespread applications. In this review, we summarize recent advances in synthetic methodologies light-emitting metallacages, highlight some representative applications these metallacages. particular, focus on favorable properties—including high luminescence efficiency various physical states, good modularity stimulus responsiveness—that have resulted from incorporating ligands displaying aggregation-induced emission (AIE) into These features show synergy between carrying out coordination-driven using luminophores with characteristics like AIE could stimulate development supramolecular fields diverse sensing, biomedicine catalysis.

Language: Английский

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Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects

TrAC Trends in Analytical Chemistry, Journal Year: 2021, Volume and Issue: 136, P. 116189 - 116189

Published: Jan. 18, 2021

Language: Английский

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