Fluorescent probes for the detection of disease-associated biomarkers

Science Bulletin, Journal Year: 2022, Volume and Issue: 67(8), P. 853 - 878

Published: Jan. 17, 2022

Language: Английский

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Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 480, P. 215020 - 215020

Published: Jan. 25, 2023

Language: Английский

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Deep learning-assisted smartphone-based ratio fluorescence for “on–off-on” sensing of Hg2+ and thiram

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134979 - 134979

Published: Feb. 3, 2022

Language: Английский

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Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Advanced Therapeutics, Journal Year: 2022, Volume and Issue: 5(2)

Published: Jan. 10, 2022

Abstract Since the 1960s membrane‐bound enzyme alkaline phosphatase (ALP) has been utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents, and even surface of nanocarriers, this enables design delivery systems that can alter their properties body on demand. Anionic nanocarriers exhibiting bioinert to interactive once having reached target site as due an ALP‐triggered cleavage anionic groups charge converts cationic improving for instance cellular uptake. Moreover, features such accumulation at or a targeted release triggered by ALP be introduced. In addition, is improve potential numerous diagnostic systems. Within review, one provides overview about activity, selectivity, distribution enzyme, well great variety applications diagnostics making use it.

Language: Английский

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Luminescent Lanthanide Infinite Coordination Polymers for Ratiometric Sensing Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 396 - 396

Published: Jan. 18, 2025

Ratiometric lanthanide coordination polymers (Ln-CPs) are advanced materials that combine the unique optical properties of ions (e.g., Eu3+, Tb3+, Ce3+) with structural flexibility and tunability polymers. These widely used in biological chemical sensing, environmental monitoring, medical diagnostics due to their narrow-band emission, long fluorescence lifetimes, excellent resistance photobleaching. This review focuses on composition, sensing mechanisms, applications ratiometric Ln-CPs. The mechanism relies two distinct emission bands, which provides a self-calibrating, reliable, precise method for detection. relative intensity ratio between these bands varies concentration target analyte, enabling real-time monitoring minimizing interference. approach is particularly suitable detecting trace analytes use complex environments where factors like background noise, temperature fluctuations, light variations may affect results. Finally, we outline future research directions improving design synthesis Ln-CPs, such as incorporating long-lifetime reference luminescent molecules, exploring near-infrared systems, developing up-conversion or two-photon materials. Progress areas could significantly broaden scope Ln-CP applications, especially biosensing, other fields.

Language: Английский

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A comprehensive overview on alkaline phosphatase targeting and reporting assays

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 465, P. 214567 - 214567

Published: May 6, 2022

Language: Английский

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Ratiometric detection and bioimaging of endogenous alkaline phosphatase by a NIR fluorescence probe

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 358, P. 131505 - 131505

Published: Jan. 31, 2022

Language: Английский

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All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and Combinational Chemodynamic–Photodynamic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17837 - 17851

Published: June 28, 2024

Currently, specific cancer-responsive fluorogenic probes with activatable imaging and therapeutic functionalities are in great demand the accurate diagnostics efficient therapy of malignancies. Herein, an all-in-one strategy is presented to realize fluorescence (FL) imaging-guided synergetic chemodynamic–photodynamic cancer by using a multifunctional alkaline phosphatase (ALP)-response aggregation-induced emission (AIE) probe, TPE-APP. By responding abnormal expression levels ALP biomarker cells, phosphate groups on AIE probe selectively hydrolyzed, accompanied situ formation strong emissive aggregates for discriminative cell over normal cells highly active quinone methide species robust activities. Consequently, activated can efficiently destroy membranes lead death within 30 min. A superior efficacy ablation demonstrated vitro vivo. The cancer-associated response-derived FL synergistic expected provide promising avenue precise image-guided therapy.

Language: Английский

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Assays for alkaline phosphatase that use L-ascorbic acid 2-phosphate as a substrate

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 495, P. 215370 - 215370

Published: Aug. 11, 2023

Language: Английский

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Alkaline phosphatase activatable near-infrared fluorescent probe for in-situ diagnosis of cholestatic liver injury

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135896 - 135896

Published: May 1, 2024

Language: Английский

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