A broad‐taxa approach as an important concept in ecotoxicological studies and pollution monitoring

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2023, Volume and Issue: 99(1), P. 131 - 176

Published: Sept. 12, 2023

ABSTRACT Aquatic invertebrates play a pivotal role in (eco)toxicological assessments because they offer ethical, cost‐effective and repeatable testing options. Additionally, their significance the food chain ability to represent diverse aquatic ecosystems make them valuable subjects for studies. To ensure consistency comparability across studies, international (eco)toxicology guidelines have been used establish standardised methods protocols data collection, analysis interpretation. However, current primarily focus on limited number of invertebrate species, mainly from Arthropoda, Mollusca Annelida. These are suitable basic toxicity screening, effectively assessing immediate severe effects toxic substances organisms. For more comprehensive ecologically relevant assessments, particularly those addressing long‐term ecosystem‐wide impacts, we recommended use broader diversity since present choice taxa exacerbates scope ecotoxicological This review provides overview focusing major how assess impact chemicals environments. The work supports broad‐taxa approach environmental as it better represents natural populations inhabiting various ecosystems. Advances omics other biochemical computational techniques feasible, enabling mechanistic studies non‐model By combining these approaches with vitro together approach, researchers can gain insights into less‐explored impacts pollution, such changes population diversity, development tolerance transgenerational inheritance pollution responses, organism phenotypic plasticity, biological invasion outcomes, social behaviour changes, metabolome regeneration phenomena, disease susceptibility tissue pathologies. also emphasises need harmonised data‐reporting standards minimum annotation checklists that research results findable, accessible, interoperable reusable (FAIR), maximising reusability data. ultimate goal is encourage integrated holistic problem‐focused collaboration between scientific disciplines, standardisation organisations decision‐making bodies, transdisciplinary knowledge co‐production One‐Health approach.

Language: Английский

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Uncovering novel disinfection mechanisms of solar light/periodate system: The dominance of singlet oxygen and metabolomic insights

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 443, P. 130177 - 130177

Published: Oct. 12, 2022

Language: Английский

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Optimized design of quaternary amino-functionalized chitosan fibers for ultra-high diclofenac adsorption from wastewater

Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 141970 - 141970

Published: April 10, 2024

Language: Английский

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Transformation products of diclofenac: formation, occurrence, and toxicity implication in the aquatic environment

Water Research, Journal Year: 2024, Volume and Issue: 266, P. 122388 - 122388

Published: Sept. 4, 2024

Language: Английский

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Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Metabolites, Journal Year: 2022, Volume and Issue: 12(2), P. 186 - 186

Published: Feb. 17, 2022

Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential elucidate the mechanisms of action (MeOAs) contaminants (in hazard assessments) and develop biomarkers biomonitoring). However, fingerprints involve complex mixture molecular effects that are hard link specific MeOA (if detected in analytical conditions used). Given these promises limitations, here we propose an updated review on achievements this approach. Metabolomics-based studies conducted pharmaceutical active compounds aquatic organisms provide relevant means approach, as prior knowledge about molecules could help overcome some shortcomings. highlighted current advances have enabled more accurate assessment, especially when combined with other omics approaches. The combination measured biological endpoints also turned out be efficient way (sub)-individual adverse outcomes, thereby paving construction outcome pathways (AOPs). Here, discuss importance determining key strategy identification MeOA-specific for biomonitoring. We put forward recommendations take full advantage thus fulfil promises.

Language: Английский

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Speed it up: How temperature drives toxicokinetics of organic contaminants in freshwater amphipods

Global Change Biology, Journal Year: 2022, Volume and Issue: 29(5), P. 1390 - 1406

Published: Nov. 30, 2022

The acceleration of global climate change draws increasing attention towards interactive effects temperature and organic contaminants. Many studies reported a higher sensitivity aquatic invertebrates contaminant exposure with or fluctuating temperatures. hypothesis this study was that the is associated changes toxicokinetic processes determine internal concentrations contaminants consequently toxic effects. Therefore, influence on underlying mechanisms were studied in two key amphipod species (Gammarus pulex Hyalella azteca). Bioconcentration experiments carried out at four different temperatures mixture 12 relevant polar Tissue medium samples taken regular intervals analysed by online solid-phase extraction liquid chromatography high-resolution tandem mass spectrometry. Subsequently, rates modelled dependence using Arrhenius equation. An exponential relationship between versus observed could be well depicted applying Due to similar uptake elimination rates, bioconcentration factors generally constant across range. Furthermore, respiration mostly similar. However, some cases (citalopram, cyprodinil), factor appeared dependent, which potentially explained active biotransformation. toxicokinetics may particularly non-equilibrated systems, such as peaks summer exemplified modelling field measured pesticide peak where increased up fourfold along gradient. results provide novel insights into chemical uptake, biotransformation scenarios can improve environmental risk assessment.

Language: Английский

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Molecular Responses of Daphnids to Chronic Exposures to Pharmaceuticals

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4100 - 4100

Published: Feb. 17, 2023

Pharmaceutical compounds are among several classes of contaminants emerging concern, such as pesticides, heavy metals and personal care products, all which a major concern for aquatic ecosystems. The hazards posed by the presence pharmaceutical is one affects both freshwater organisms human health-via non-target effects contamination drinking water sources. molecular phenotypic alterations five pharmaceuticals commonly present in environment were explored daphnids under chronic exposures. Markers physiology enzyme activities combined with metabolic perturbations to assess impact metformin, diclofenac, gabapentin, carbamazepine gemfibrozil on daphnids. Enzyme activity markers included phosphatases, lipase, peptidase, β-galactosidase, lactate dehydrogenase, glutathione-S-transferase glutathione reductase activities. Furthermore, targeted LC-MS/MS analysis focusing glycolysis, pentose phosphate pathway TCA cycle intermediates was performed alterations. Exposure resulted changes enzymes metabolism detoxification glutathione-S-transferase. Metabolic key pathways revealed distinct groups fingerprints different exposures their mixtures. Chronic exposure at low concentrations significant physiological endpoints.

Language: Английский

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Exposure to chemical and commercial forms of NSAIDs at environmentally relevant concentrations exert transgenerational metabolic responses in daphnids

Water Biology and Security, Journal Year: 2025, Volume and Issue: unknown, P. 100404 - 100404

Published: April 1, 2025

Language: Английский

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Long-term exposure to environmental diclofenac concentrations impairs growth and induces molecular changes in Lymnaea stagnalis freshwater snails

Chemosphere, Journal Year: 2021, Volume and Issue: 291, P. 133065 - 133065

Published: Nov. 27, 2021

Language: Английский

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A multi-biomarker approach to assess toxicity of diclofenac and 4-OH diclofenac in Mytilus trossulus mussels - First evidence of diclofenac metabolite impact on molluscs

Environmental Pollution, Journal Year: 2022, Volume and Issue: 315, P. 120384 - 120384

Published: Oct. 9, 2022

Although the presence of pharmaceuticals in environment is an issue widely addressed research over past two decades, still little known about their transformation products. However, there are indications that some these chemicals may be equally or even more harmful than parent compounds. Diclofenac (DCF) among most commonly detected aquatic environment, but potential effects its metabolites on organisms poorly understood. Therefore, present study aimed to evaluate and compare toxicity DCF metabolite, 4-hydroxy diclofenac (4-OH DCF), mussels using a multi-biomarker approach. Mytilus trossulus were exposed 4-OH at 68.22 20.85 μg/L (measured concentrations day 0), respectively, for 7 days. In our work, we showed both tested compounds have no effect enzymatic biomarkers tested. it has been shown action can affect protein content gills also reflected through histological markers. ENVIRONMENTAL IMPLICATION: Studies recent years clearly prove negatively organisms. addition compounds, significant environmental problem. main diclofenac, marine evaluated. Both negative mussels, which was primarily observed changes. The therefore confirms not only metabolite

Language: Английский

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