Phthalates Promote Dissemination of Antibiotic Resistance Genes: An Overlooked Environmental Risk

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(17), P. 6876 - 6887

Published: April 21, 2023

Plastics–microorganism interactions have aroused growing environmental and ecological concerns. However, previous studies concentrated mainly on the direct paid little attention to ecotoxicology effects of phthalates (PAEs), a common plastic additive that is continuously released accumulates in environment. Here, we provide insights into impacts PAEs dissemination antibiotic resistance genes (ARGs) among microorganisms. Dimethyl phthalate (DMP, model PAE) at environmentally relevant concentrations (2–50 μg/L) significantly boosted plasmid-mediated conjugation transfer ARGs intrageneric, intergeneric, wastewater microbiota by up 3.82, 4.96, 4.77 times, respectively. The experimental molecular dynamics simulation results unveil strong interaction between DMP molecules phosphatidylcholine bilayer cell membrane, which lowers membrane lipid fluidity increases permeability favor ARGs. In addition, increased reactive oxygen species generation conjugation-associated gene overexpression under stress also contribute transfer. This study provides fundamental knowledge PAE–bacteria broaden our understanding risks plastics, especially niches with colonized microbes, guide control ARG spreading.

Language: Английский

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From biofilms to biocatalysts: Innovations in plastic biodegradation for environmental sustainability

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 374, P. 124192 - 124192

Published: Jan. 21, 2025

Language: Английский

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Impacts of Biofilm Formation on the Physicochemical Properties and Toxicity of Microplastics: A Concise Review

Reviews of Environmental Contamination and Toxicology, Journal Year: 2023, Volume and Issue: 261(1)

Published: May 12, 2023

Language: Английский

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Microplastics provide new hotspots for frequent transmission of antibiotic resistance genes during anaerobic digestion of sludge containing antibiotics

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 486, P. 149979 - 149979

Published: Feb. 24, 2024

Language: Английский

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Phthalates Boost Natural Transformation of Extracellular Antibiotic Resistance Genes through Enhancing Bacterial Motility and DNA Environmental Persistence

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(17), P. 7291 - 7301

Published: April 16, 2024

The environmental dissemination of extracellular antibiotic resistance genes (eARGs) in wastewater and natural water bodies has aroused growing ecological concerns. coexisting chemical pollutants are known to markedly affect the eARGs transfer behaviors microbial community, but detailed interactions specific impacts remain elusive so far. Here, we revealed a concentration-dependent impact dimethyl phthalate (DMP) several other types esters (common released from plastics) on transformation eARGs. DMP exposure at an environmentally relevant concentration (10 μg/L) resulted 4.8-times raised frequency Acinetobacter baylyi severely suppressed high (1000 μg/L). promotion by low-concentration was attributed multiple mechanisms, including increased bacterial mobility membrane permeability facilitate uptake improved DMP-bounded (via noncovalent interaction) enzymatic degradation (with DNase activity). Similar promoting effects were also found real biofilm systems. In contrast, higher-concentration disrupting DNA structure. Our findings highlight potentially underestimated spreading aquatic environments due deepen our understanding risks biological-chemical combined pollution bodies.

Language: Английский

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Prediction of HC5s for phthalate esters by use of the QSAR–ICE model and ecological risk assessment in Chinese surface waters

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 467, P. 133642 - 133642

Published: Jan. 28, 2024

Language: Английский

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Efficient nitrate and Cr(VI) removal by denitrifier: The mechanism of S. oneidensis MR-1 promoting electron production, transportation and consumption

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133675 - 133675

Published: Feb. 1, 2024

Language: Английский

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Bisphenol A sorption on commercial polyvinyl chloride microplastics: Effects of UV-aging, biofilm colonization and additives on plastic behaviour in the environment.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124218 - 124218

Published: May 28, 2024

Chemical additives are important components in commercial microplastics and their leaching behaviour has been widely studied. However, little is known about the potential effect of on adsorption/desorption pollutants subsequent role as vectors for pollutant transport environment. In this study, two types polyvinyl chloride (PVC

Language: Английский

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Impact of Polyethylene Terephthalate Microplastics on Aerobic Granular Sludge Structure and EPS Composition in Wastewater Treatment

Water, Journal Year: 2025, Volume and Issue: 17(2), P. 270 - 270

Published: Jan. 18, 2025

Aerobic granular sludge (AGS) is a promising technology for wastewater treatment. Granules have compact microbial structure and high potential pollutant removal. Despite its advantages, the impact of microplastics (MPs) on AGS remains poorly understood, posing risk to stability efficiency biological treatment processes. This study investigates effects polyethylene terephthalate (PET) MPs extracellular polymeric substance (EPS) composition, providing new insights into interaction between AGS. Four sequencing batch reactors (GSBRs) were operated with varying concentrations PET in influent (0, 1, 10, 50 mg/L). Key findings include MP-induced changes granule size distribution, an increase smaller granules (<90 µm) observed exposed MPs. EPS (51–77 mg/L) exhibited significant differences among reactors, notable shifts protein (PN) polysaccharide (PS) fractions. A higher MP dose resulted increased PN/PS ratio (from 1.96 5.40) elevated hydrophobicity These suggest that can alter potentially affecting performance. provides novel evidence disruptive systems, emphasizing need address pollution context The results contribute deeper understanding interactions form basis strategies mitigate their adverse effects.

Language: Английский

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Occurrences and implications of pathogenic and antibiotic-resistant bacteria in different stages of drinking water treatment plants and distribution systems

Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e26380 - e26380

Published: Feb. 1, 2024

Different stages of drinking water treatment plants (DWTPs) play specific roles in diverse contaminants' removal present natural sources. Although the are recorded to promote adequate water, occurrence pathogenic bacteria (PB) and antibiotic-resistant (ARB) treated changes their diversity abundance as it passed down end users through distribution systems (DWDSs), is a great concern, especially human health. This could imply that different system provide good microenvironment for growth. Hence, becomes pertinent constantly monitor document PB ARB at each stage system. review aimed documenting well implication globally. An exhaustive literature search from Web Science, Science-Direct database, Google Scholar, Academic Research Databases like National Center Biotechnology Information, Scopus, SpringerLink was done. The obtained information showed influence proliferate. To minimize health risks associated with these PB, review, suggests development advanced technologies can quick monitoring PB/ARB reduction cost environomics analysis better microbial analysis.

Language: Английский

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