Bioaccumulation and Potential Endocrine Disruption Risk of Legacy and Emerging Organophosphate Esters in Cetaceans from the Northern South China Sea

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Despite the increasing health risks shown by continuous detection of organophosphate esters (OPEs) in biota recent years, information on occurrence and potential OPEs marine mammals remains limited. This study conducted first investigation into body burdens 10 traditional (tOPEs) five emerging (eOPEs) cetacean species (n = 84) from northern South China Sea (NSCS) during 2005–2021. All OPEs, except for 2-ethylhexyl diphenyl phosphate (EHDPHP), were detected these cetaceans, indicating their widespread NSCS. Although levels ∑10tOPEs humpback dolphins remained stable 2005 to 2021, concentrations ∑5eOPEs showed a significant increase, suggesting growing demand new-generation China. Dolphins proximity urban regions generally exhibited higher OPE than those rural areas, mirroring environmental trends occurring this area. congeners, EHDPHP, maternal transfer ratio >1, that dolphin placenta may not be an efficient barrier OPEs. The observed correlations between hormones (triiodothyronine, thyroxine, testosterone) indicated exposures might have endocrine disruption effects population.

Language: Английский

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Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 441, P. 129939 - 129939

Published: Sept. 7, 2022

Language: Английский

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Legacy and novel brominated flame retardants in agricultural soils of eastern China (2011–2021): Concentration level, temporal trend, and health risk assessment

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 446, P. 130631 - 130631

Published: Dec. 29, 2022

Language: Английский

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Estimation of Per- and Polyfluorinated Alkyl Substance Induction Equivalency Factors for Humpback Dolphins by Transactivation Potencies of Peroxisome Proliferator-Activated Receptors

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(9), P. 3713 - 3721

Published: Feb. 22, 2023

The potential risks of per- and polyfluoroalkyl substance (PFAS) accumulation in nearshore dolphins are not well understood. Here, transcriptional activities 12 PFAS on peroxisome proliferator-activated receptors (PPAR-α, -β/δ, -γ) Indo-Pacific humpback (Sousa chinensis) were evaluated. All activated scPPAR-α a dose-dependent manner. PFHpA exhibited the highest induction equivalency factors (IEFs). order IEFs for other was as follows: PFOA > PFNA PFHxA PFPeA PFHxS PFBA PFOS PFBuS ≈ PFDA ≫ PFUnDA PFDoDA (not activated). total equivalents (∑IEQs, 5537 ng/g wet weight) indicated that more attention should be paid to investigating contamination levels dolphins, especially (82.8% contribution ∑IEQs). scPPAR-β/δ -γ affected by any PFAS, except PFOS, PFNA, PFDA. Furthermore, could induce higher PPAR-β/δ PPAR-γ-mediated than PFOA. Compared human beings, might potent PPAR-α activators suggesting may susceptible adverse effects PFAS. Our results instructive understanding impacts marine mammal health due identical PPAR ligand-binding domain.

Language: Английский

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Risk assessment of phthalate metabolites accumulated in fish to the Indo-Pacific humpback dolphins from their largest habitat

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 876, P. 163094 - 163094

Published: March 28, 2023

Language: Английский

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Fatty Acid Profiles Linked to Organohalogen Exposure in Cetaceans from the Northern South China Sea

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Increasing evidence suggests that organohalogen contaminants (OHCs) could disrupt lipid metabolism in organisms, prompting consideration of fatty acids (FAs) as biological tools for assessing chemical stress systems. This study examined 87 OHCs and 32 FAs two sentinel cetacean species─Indo-Pacific humpback dolphins (n = 128) Indo-Pacific finless porpoises 26)─from the northern South China Sea (NSCS), a global hotspot OHCs. Our results revealed higher OHC levels these cetaceans than averages. We identified 347 significant correlations between 79 FAs, including associations with long-chain n-3 polyunsaturated acids, which are critical health. Furthermore, 45 were found desaturated enzyme activities/lipogenic indexes, suggesting may cetaceans. Polybrominated diphenyl ethers legacy flame retardants major contributors to OHC-FA relationships. Moreover, alternative halogenated retardants, PBDE substitutes, similarly impact FA metabolism, raising concerns regarding their safety. findings support potential use bioindicators evaluating exposure risks Future research is needed elucidate mechanisms consequences exposure-associated lipid-disrupting effects occurring NSCS

Language: Английский

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Endocrine-Disrupting Chemical Exposure Induces Adverse Effects on the Population Dynamics of the Indo-Pacific Humpback Dolphin

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(21), P. 9102 - 9112

Published: May 16, 2024

Cetaceans play a pivotal role in maintaining the ecological equilibrium of ocean ecosystems. However, their populations are under global threat from environmental contaminants. Various high levels endocrine-disrupting chemicals (EDCs) have been detected cetaceans South China Sea, such as Indo-Pacific humpback dolphins Pearl River Estuary (PRE), suggesting potential health risks, while impacts endocrine disruptors on dolphin population remain unclear. This study aims to synthesize dynamics PRE and profiles EDC contaminants 2005 2019, investigating EDCs dolphins. Our comprehensive analysis indicates sustained decline population, posing significant risk extinction. Variations sex hormones induced by exposure could potentially impact birth rates, further contributing decline. Anthropogenic activities consistently emerge most stressor, ranking highest importance. Conventional demonstrate more pronounced compared emerging compounds. Among conventional pollutants, DDTs take precedence, followed zinc chromium. The impactful identified alkylphenols. Notably, profile changes, significance pollutants may give way EDCs, presenting continued challenge viability population.

Language: Английский

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Organotins in fish, shrimp, and cephalopods from the Pearl River Estuary, China: Dietary exposure risk to Indo-Pacific humpback dolphin and human

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166634 - 166634

Published: Aug. 27, 2023

Language: Английский

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Mechanistic characterization of anaerobic microbial degradation of BTBPE in coastal wetland soils: Implication by compound-specific stable isotope analysis

Journal of Environmental Management, Journal Year: 2023, Volume and Issue: 335, P. 117622 - 117622

Published: March 1, 2023

Language: Английский

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Novel Insights into Uptake, Translocation, and Transformation Mechanisms of 2,2′,4,4′-Tetra Brominated Diphenyl Ether (BDE-47) in Wheat (Triticum aestivum L.): Implication by Compound-Specific Stable Isotope and Transcriptome Analysis

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(40), P. 15266 - 15276

Published: Sept. 29, 2023

The uptake, translocation, and transformation of 2,2',4,4'-tetra brominated diphenyl ether (BDE-47) in wheat (Triticum aestivum L.) were comprehensively investigated by hydroponic experiments using compound-specific stable isotope analysis (CSIA) transcriptome analysis. results indicated that BDE-47 was quickly adsorbed on epidermis roots then absorbed via water anion channels as well an active process dependent energy. A small fraction subjected to translocation acropetally, increase δ13C values shoots than implied had cross at least one lipid bilayer enter the vascular bundle transporters. In addition, accompanied decreasing concentrations, showed increasing trend with time shoots, indicating occurrence transformation. OH-PBDEs detected products, hydroxyl group preferentially substituted ortho-positions BDE-47. Based analysis, genes encoding polybrominated (PBDE)-metabolizing enzymes, including cytochrome P450 nitrate reductases, glutathione S-transferases, significantly upregulated after exposure further evidencing This study first reported carbon fractionation PBDEs during plants, application CSIA allowed systematically characterize environmental behaviors pollutants plants.

Language: Английский

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