Published: Jan. 1, 2025
Language: Английский
Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(4), P. 292 - 301
Published: March 9, 2023
The comprehensive characterization of per- and polyfluoroalkyl substances (PFASs) is necessary for the effective assessment management risk at contaminated sites. While current analytical methods are capable quantitatively measuring a number specific PFASs, they do not provide complete picture thousands PFASs that utilized in commercial products potentially released into environment. These unmeasured include many PFAS precursors, which may be converted related chemicals through oxidation. total oxidizable precursor (TOP) assay offers means bridging this gap by oxidizing unknown precursors intermediates converting them stable with established standards. application TOP to samples from PFAS-contaminated sites has generated several new insights, but it also presented various technical challenges laboratories. Despite increased literature studies assay, there critical growing method beyond researchers academia. This article outlines benefits using aqueous site assessments suggests ways address some its limitations.
Language: Английский
Citations
53
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 3, 2024
Per- and polyfluoroalkyl substances (PFAS) are a diverse class of highly persistent anthropogenic chemicals that detectable in the serum most humans. PFAS exposure has been associated with many adverse effects on human health including immunotoxicity, increased risk certain cancers, metabolic disruption. binding to abundant blood proteins (human albumin [HSA] globulins) is thought affect transport active sites, toxicity, elimination half-lives. However, few studies have investigated competitive these serum. Here, we use C18 solid-phase microextraction fibers measure HSA–water globulin–water distribution coefficients (DHSA/w, Dglob/w) for carbon chains containing 4 13 perfluorinated carbons (ηpfc = 4–13) several functional head-groups. ηpfc < 7 were bound HSA relative globulins, whereas ≥ showed greater propensity globulins. Experimentally measured DHSA/w Dglob/w concentrations successfully predicted variability We estimated unbound fraction varied by up factor 2.5 among individuals participating 2017–2018 U.S. National Health Nutrition Examination Survey. These results suggest globulins important covariates epidemiological aimed at understanding exposure.
Language: Английский
Citations
27
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240
Published: Jan. 1, 2025
This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information
Language: Английский
Citations
4
Microbial Biotechnology, Journal Year: 2023, Volume and Issue: 16(6), P. 1091 - 1111
Published: March 7, 2023
There is much human disadvantage and unmet need in the world, including deficits basic resources services considered to be rights, such as drinking water, sanitation hygiene, healthy nutrition, access healthcare, a clean environment. Furthermore, there are substantive asymmetries distribution of key among peoples. These can lead local regional crises peoples competing for limited resources, which, turn, become sources discontent conflict. Such conflicts have potential escalate into wars even global instability. Ergo: addition moral ethical imperatives level up, ensure that all essential living reduce inequalities, nations self-interest pursue with determination available avenues promote peace through reducing world. Microorganisms pertinent microbial technologies unique exceptional abilities provide, or contribute provision of, lacking many parts thereby address might constitute However, deployment this end seriously underexploited. Here, we highlight some emerging demand greater consideration exploitation endeavours eliminate unnecessary deprivations, enable lives remove preventable grounds competition over We exhort central actors: microbiologists, funding agencies philanthropic organisations, politicians worldwide international governmental non-governmental engage - full partnership relevant stakeholders, 'weaponise' microbes fight resource asymmetries, particular most vulnerable populations, create humanitarian conditions more conducive harmony peace.
Language: Английский
Citations
28
Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)
Published: July 1, 2024
Environmental contamination by fluorinated chemicals, in particular chemicals from the per- and polyfluoroalkyl substances (PFAS) class, has raised concerns around globe because of documented adverse impacts on human health, wildlife, ecosystem quality. Recent studies have indicated that pesticide products may contain a variety meet PFAS definition, including active ingredients themselves. Given pesticides are some most widely distributed pollutants across world, legacy addition into could be widespread wide-ranging implications agriculture food water contamination, as well presence rural environments.
Language: Английский
Citations
14
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 933, P. 173157 - 173157
Published: May 11, 2024
Language: Английский
Citations
10
Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(4), P. 350 - 356
Published: March 14, 2024
Hundreds of sites across the United States have high concentrations perfluoroalkyl sulfonamides (FASA), but little is known about their propensity to accumulate in fish. FASA are precursors terminal per- and polyfluoroalkyl substances (PFAS) that abundant diverse consumer products aqueous film-forming foams manufactured using electrochemical fluorination (ECF AFFF). In this study, with C3-C8 carbon chain lengths were detected all fish samples from surface waters up 8 km downstream source zones ECF AFFF contamination. Short-chain ≤ C6 rarely been included routine screening for PFAS, availability new standards makes such analyses more feasible. Bioaccumulation factors (BAF) between 1 3 orders magnitude greater than sulfonates. Across species, BAF perfluorooctanesulfonate (PFOS), which presently focus national advisory programs. Similar (<0.36-175 ng g-1) PFOS (0.65-222 species. No safety thresholds established FASA. However, next contaminated preliminary findings on toxicity suggest an urgent need consideration by
Language: Английский
Citations
9
Water Research, Journal Year: 2024, Volume and Issue: 257, P. 121675 - 121675
Published: April 24, 2024
Language: Английский
Citations
9
Environmental Science & Technology Letters, Journal Year: 2025, Volume and Issue: 12(2), P. 104 - 112
Published: Jan. 23, 2025
Per- and polyfluoroalkyl substances (PFAS) have garnered increasing attention in recent years, non-targeted analysis (NTA) has become essential for elucidating novel PFAS structures. NTA research been dominated by liquid chromatography–mass spectrometry (LC-MS) with gas (GC-MS) used less often as evidenced bibliometrics. However, the performance of GC-MS studies (GC-NTA) rivals that LC-ESI-MS, is shown to cover a complementary chemical space. An LC-ESI-MS amenability model applied list approximately 12,000 revealed than 10% known chemistry predicted be amenable typical LC-MS analysis. Therefore, there strong potential applying methods more fully assess environmental contamination landscape, uniquely shedding light on both PFAS, especially within space realm volatile semivolatile PFAS. Waste streams from fluorochemical manufacturing facilities heavily studied using targeted GC-MS; however, GC-NTA needed discover are not emitted facilities. Studies incineration PFAS-containing materials, such aqueous film forming foam, focused destruction parent compounds, little about transformation products formed during processes. holds elucidate when incinerated. Wastewater treatment plants landfills sources environment, yet understand air emissions these sources. Consumer lead indoor exposures via dust, but this area either or GC-MS. Despite challenges advancing GC-NTA, we call researchers, grantors, managers, other stakeholders recognize necessity so may face together.
Language: Английский
Citations
1
Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1345, P. 343746 - 343746
Published: Jan. 31, 2025
Language: Английский
Citations
1