PFAS Contamination and Mitigation: A Comprehensive Analysis of Research Trends and Global Contributions

Case Studies in Chemical and Environmental Engineering, Journal Year: 2025, Volume and Issue: 11, P. 101127 - 101127

Published: Feb. 1, 2025

Language: Английский

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Scientists’ warning on fossil fuels

Oxford Open Climate Change, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 1, 2025

Abstract The evidence is clear that fossil fuels—and the fuel industry and its enablers—are driving a multitude of interlinked crises jeopardize breadth stability life on Earth. Every stage cycle—extraction, processing, transport, combustion or conversion to petrochemical products—emits planet-heating greenhouse gases health-harming pollutants, in addition causing widespread environmental degradation. We review vast scientific showing fuels are root cause climate crisis, harm public health, worsen injustice, accelerate biodiversity extinction, pollution crisis. Fossil responsible for millions premature deaths, trillions dollars damages, escalating disruption ecosystems, threatening people, wildlife, livable future. has obscured concealed this through decades-long, multi-billion-dollar disinformation campaign aimed at blocking action phase out fuels. focus United States as world’s largest oil gas producer dominant contributor these crises. present science-and-justice-based solutions already exist governments civil society restrict influence industry, stop expansion, production use, make rapid, just transition clean, renewable energy materials across economy, while holding accountable deception damages. necessary away from will provide innumerable societal planetary benefits forge path forward sustaining

Language: Английский

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Potential for biological effects of per- and polyfluoroalkyl substances (PFAS) in Great Lakes tributaries and associations with land cover and wastewater effluent

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Surface water concentrations of per- and polyfluoroalkyl substances (PFAS) potential for resulting biological effects were estimated in a study using Polar Organic Chemical Integrative Samplers (POCIS) from 60 tributary sites within 20 watersheds the Great Lakes Basin 2018. Sites represented range urban to agricultural, forested, wetland land uses included gradient wastewater treatment effluent zero 44% annual streamflow. Several also had airport influence. Twenty-one 32 targeted PFAS compounds detected POCIS samplers, which, 16 available sampling rates enabling time-weighted concentration estimates comparison with data. Estimated compared published quality guidelines (available nine PFAS), effect reported primary literature ECOTOX Knowledgebase apical endpoints (10 PFAS) non-apical vitro high-throughput screening data ToxCast (14 PFAS). Based on conservative evaluation approach that was weighted persistence limitations toxicological information, five individual PFAS, including Perfluorooctanesulfonic acid, Perfluorohexanesulfonic Perfluorobutanesulfonic Perfluorooctanoic Perfluorononanoic acid identified as warranting additional investigation. Possible increased potency mixtures over chemical effects, by summation exposure-activity ratios (EARs) chemicals influence common assays specified gene targets, indicated EAR values up 5.6-fold 14 contributing mixture predictions. Potential summed ratios, correlated use proportion streamflow contributed effluent.

Language: Английский

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Pseudozyma aphidis bio-active extract inhibit plant pathogens and activate induce resistance in tomato plants

Published: Jan. 4, 2025

Abstract The constant growth in the world population demands a increase agricultural yields. One of main ways to yields is by improving control pests and pathogens. Human health environmental concerns regarding traditional synthetic pesticides challenge scientific community discover new less harmful pests, such as development biocontrol agents natural-based pesticides. Previous studies have established that application live P. aphidis can be used for diverse fungal bacterial phytopathogens. Here demonstrate activity two semi-purified fractions from , one containing antimicrobial metabolites other resistance inducing metabolites. Our results vitro experiments with extract show strongly inhibit important In planta demonstrated significant, dose-dependent reduction disease infection when spore suspension B. cinerea was treated or exposed extracted From hand, our showed aqueous fraction on tomato plants rapidly up-regulated expression defense-related genes, which are associated both induced systemic acquired pathways. conclusion, this study further enhances understanding biochemical mechanisms behind modes action: antibiosis resistance. It also demonstrates great potential unique agent source and/or enhanced substances.

Language: Английский

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The Rise and Risks of Fluorinated Pesticides: A Call for Comprehensive Research to Address Environmental and Health Concerns

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

InfoMetricsFiguresRef. Journal of Agricultural and Food ChemistryASAPArticle This publication is free to access through this site. Learn More CiteCitationCitation abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse ViewpointJanuary 13, 2025The Rise Risks Fluorinated Pesticides: A Call for Comprehensive Research Address Environmental Health ConcernsClick copy article linkArticle link copied!Ravikumar JaganiRavikumar JaganiLautenberg Sciences Laboratory, Department Medicine Climate Science, Icahn School at Mount Sinai, New York, York 10029, United StatesMore by Ravikumar Jaganihttps://orcid.org/0000-0002-7680-860XHiraj PatelHiraj PatelLautenberg Hiraj PatelJasmin ChovatiyaJasmin ChovatiyaLautenberg Jasmin ChovatiyaSyam S. Andra*Syam AndraLautenberg States*[email protected]More Syam Andrahttps://orcid.org/0000-0003-2839-6417Open PDFJournal ChemistryCite this: J. Agric. Chem. 2025, XXXX, XXX, XXX-XXXClick citationCitation copied!https://pubs.acs.org/doi/10.1021/acs.jafc.4c12827https://doi.org/10.1021/acs.jafc.4c12827Published January 2025 Publication History Received 20 December 2024Published online 13 2025article-commentary© American Chemical Society. available under these Terms Use. Request reuse permissionsThis licensed personal use The ACS Publications© SocietyThe Agrochemicals: Double-Edged SwordClick section linkSection copied!The agricultural sector has witnessed a dramatic shift in pest management strategies over the past few decades, with fluorinated pesticides emerging as dominant force. (1−4) From modest 9% market share turn century, compounds now account more than half newly approved pesticides, nearly 70% agrochemicals recent years containing fluorine. (4) surge popularity driven unique properties that fluorination imparts, including enhanced stability, lipophilicity, bioavailability. (5) While characteristics have undoubtedly contributed improved control productivity, they also given rise pressing environmental health concerns demand urgent attention from food chemistry research community. Table 1 lists key aspects findings, sections below outline priorities address issues.Table 1. : Key Aspects Concerns, Listed Alphabetically, Findings Regarding Pesticidesaspect or concerndetailsresearch findingsimplicationsrefaactive ingredient fluorinationhigh level proportion active ingredientsin decade, 61% U.S. conventional pesticide components were organofluorines 30% PFAS, up 23% 14%, respectively, between 2012 2021widespread potential accumulation (1)bioaccumulationaccumulation various organismsfound honeybees (≤140 ng per bee), aquatic organisms, terrestrial wildlifepotential biomagnification chains ecosystem disruption (4)detection challengesneed effective monitoring methodsdevelopment novel fluorescent probe N-(purinyl)-2-chromene-3-carbohydrazide (PCC)improved detection specific (10)endocrine disruptioninterference hormone systemsepoxiconazole inhibits monooxygenases activity steroidogenesis rats human cell linespotential reproductive developmental issues wildlife humans (4)environmental justicedisproportionate exposure certain communitieshigher levels PFAS application near water systems serving Latinx non-Latinx People Color.unequal distribution risks (7)environmental persistencehigh stability carbon–fluorine bonds, long half-lives pesticidesC–F bond energy 485 kJ mol–1; many exceeding 30 days, some 365 days (2416 pydiflumetofen 500 bixafen)long-term contamination bioaccumulation (2), (4)food contaminationresidues found productsepoxiconazole detected 17.6 μg/kg crops; freshwater fish livestockhuman diet (4)formation toxic byproducts metabolitesphotolysis can produce potentially compounds; partial degradation lead formation metaboliteslevels trifluoroacetate difluoroacetate increased oxidizing conditions; multiple photoproducts retained structures similar those parent metabolites may be persistent compoundspotential toxicity products, additional breakdown products wastewater (6), (11)genotoxicityDNA chromosomal damagefipronil, λ-cyhalothrin, cyfluthrin cause genetic damagepotential long-term effects, risk cancer (4)groundwater threatpotential drinking sourcesPFAS-contaminated used within km 732 serviced 18.5 million Californians; 229 978 mg PFOS, PFBS, PFBA applied public supply wells via (2019–2021)ongoing resources risks, widespread (7)immunotoxicityimpacts on immune system functionflupyradifurone impairs pathways bees sublethal concentrations; fipronil shown immunosuppressive effects micepotential susceptibility diseases exposed organisms (4)impact microbial communitiesfluorinated affect populations treatment systemsinhibitory observed involved processespotential reduction efficiency (6)incomplete degradationeven when degrade, often remaincomplete fluorine mass balances demonstrated retention byproducts; maximal defluorination ranged 6.1% 100% depending chemical conditionscontinued presence organic even after (11)increasing prevalencerapid growth approvalsnearly new latter decade fluorinatedpotential (4)industrial trendscontinued importance halogenated agrochemicalsincrease production halogen-substituted agrochemicals: F (40%) > F/Cl (13%) Cl/Br (3%) = F/Br (3%); 77% (2016–2022) are substituted halogenongoing development (3)lack transparencynondisclosure inert ingredientsinert ingredients adjuvants not required labelsdifficulty assessing full profile formulations (12)oxidative stressfluorinated induce reactive oxygen species (ROS) formationenzymes, lipids, protein expression changedcellular damage physiological disruptions (5)persistence wastewaterhigh resistance plantssome remain largely unaffected biological bodies receiving treated effluent (6)plastic interactionadsorption microplasticsepoxiconazole shows high adsorption polyethylene microplasticsenhanced persistence long-range transport (4)recalcitrance biodegradationmicroorganisms struggle break down compoundsfew known enzymes catalyze reactions; biodegradation leaves metabolitesaccumulation environment (9)regulatory comprehensive assessment inadequate compoundsexclusion proposed restrictions REACH, European chemicals regulation; current evaluations fully pesticidespotential gaps regulation underestimation impacts (8), (12)soil contaminationwidespread soil programsbroflanilide epoxiconazole frequently most common pollutants soils because their affinity soillong-term crop uptake (4)structural complexityincreasing stereogenic centers molecules∼48% modern chiral moleculeschallenges varied (2)TFA potentialpesticides substantial source TFA143 C–CF3 groups forming TFA currently EU, USA, China; estimated maximum emissions ≤83 kg/km2 year across Europesignificant contribution (8)types fluorine-containing groupscommon substituents pesticides52% contain trifluoromethyl (F3C) groups, 20% difluoromethyl (F2HC) 4% trifluoromethoxy (F3C–O) groupsdiverse range entering (3)variability degradationdifferent motifs varying photolysis conditionsaryl heteroaromatic easily defluorinated, while CF3 CF2 stablechallenges predicting fate designing processes (11)water contaminationpresence surface groundwatercyfluthrin 1380 ng/L fluometuron 1270 environmentsthreat ecosystems (4)aThis refers primary one provides citations article.The Urgent Need Fate StudiesClick critical issue requires immediate focus. Studies ecosystems, environments wildlife. (4,6−8) Some exhibit soil, indicating contamination. only affects area but leads spread nontarget mechanisms.Research Priority. studies urgently needed. These should include (1) detailed investigations metabolite different compartments (soil, water, air), (2) factors influencing mobility compounds, (3) evaluation impact conditions (pH, temperature, activity) transformation pesticides.Bioaccumulation Chain Impacts: Growing ConcernClick lipophilic nature contributes propensity living organisms. Evidence been ranging animals. raises significant about chains, affecting higher trophic levels, humans. (4)Research In-depth crucial. areas focus mechanisms uptake, accumulation, biotransformation transfer rates magnification accumulate edible crops livestock, implications safety.Ecotoxicological Unraveling Complex InteractionsClick copied!Ecotoxicological unveiled adverse endocrine disruption, toxicity, immunotoxicity. However, our understanding impacts, particularly complex remains limited.Research Expanded ecotoxicological essential, focusing long-term, multigenerational assess chronic species, investigation synergistic interact other contaminants, ecosystem-level understand broader ecological use.Human Implications: Bridging Critical Knowledge GapsClick growing concern demands rigorous investigation. blood samples, raising questions effects. (7) linked issues, kidney cancer, cardiovascular problems, (1)Research needed, epidemiological endocrine, reproductive, systems, biomonitoring extent (occupational, dietary, environmental), transgenerational epigenetic exposure.Metabolite Toxicity: An Overlooked DimensionClick equally compounds. (4,9) aspect overlooked traditional assessments.Research Focused crucial, identification characterization major formed persistence, metabolites, analytical methods detecting quantifying matrices.Alternative Development: Pursuing Safer SolutionsClick copied!As grow, there an increasing need explore alternative develop less agrochemicals. presents opportunity innovation field chemistry.Research Development safer alternatives focus, design synthesis nonfluorinated match efficacy minimizing exploration biopesticides synthetic delivery could reduce pesticides.Analytical Challenges: Improving Detection MonitoringClick complexity diversity pose challenges. (10,11) Improved matrices essential assessment.Research Advancement techniques sensitive, high-throughput simultaneous standardization protocols ensure comparability data regions, techniques, such nontargeted analysis, identify unknown matrices.Regulatory Science: Informing Policy Robust DataClick copied!Current regulatory frameworks approval challenges posed There approaches consider cumulative degradates ingredients.Research support evidence-based decisions models inform mixture assessments, thresholds adequacy protecting health.Conclusion: Interdisciplinary ResearchClick time action now. We must prioritize bridges knowledge gaps, develops alternatives, scientific basis sound decisions. Only efforts we hope balance benefits imperative health.Author InformationClick copied!Corresponding AuthorSyam Andra - Lautenberg States; https://orcid.org/0000-0003-2839-6417; Email: [email protected]AuthorsRavikumar Jagani https://orcid.org/0000-0002-7680-860XHiraj Patel StatesJasmin Chovatiya StatesFundingThis work was partially funded National Institute Institutes Health, Grant P30 ES023515 Robert O. Wright [Mount Sinai Center Environment Across LifeSpan (HEALS)], U2CES026561 (Mount HHEAR Targeted Analysis Laboratory), U2CES030859 Manish Arora Untargeted Laboratory).NotesThe authors declare no competing financial interest.ReferencesClick copied! references 12 publications. 1Donley, N.; Cox, C.; Bennett, K.; Temkin, A. M.; Andrews, D. Q.; Naidenko, V. Forever Source Contamination Environment. Environ. Perspect. 2024, 132 (7), 75003, DOI: 10.1289/EHP13954 Google ScholarThere corresponding record reference.2Jeschke, P. Recent developments pesticides. Pest Manage. Sci. 80 3065– 3087, 10.1002/ps.7921 reference.3Jeschke, Active Ingredients Sustainable Modern Crop Protection Agriculture. ChemSusChem e202401042 10.1002/cssc.202401042 reference.4Alexandrino, Almeida, C. M. R.; Mucha, P.; Carvalho, F. Revisiting pollution: case Pollut. 2022, 292, 118315, 10.1016/j.envpol.2021.118315 Scholar4Revisiting pesticidesAlexandrino, Diogo Marisa Ana Maria F.Environmental Pollution (Oxford, Kingdom) (2022), 292 (Part_A), 118315CODEN: ENPOEK; ISSN:0269-7491. (Elsevier Ltd.) review. acquired agrochem. due fluoroorg. last two decades. trend accompanied framework entailing all neg. environment, esp. considering hazardous result incorporation into org. mols. review aims safe/hazardous dichotomy assocd. providing updated outlook relevancy how it role pollutants. Specifically, discussed, analyzing act substances non-target >> SciFinder ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BB3MXit1ektL%252FJ&md5=7ced1326803e2dacae7dcc28170a7ab15Mesquita, F.; Gonçalves, Lethal Sub-Lethal Effects Copper-Based Pesticides-A Review. Int. Res. Public 2023, (4), 3706, 10.3390/ijerph20043706 reference.6Omotola, Adekilekun, K. T.; Solomon, O.; Muizzat, I.; Oluranti, B. Compounds Wastewater Treatment Plants. In Fluoride Fluorocarbon Sources, Issues, Remediation; Kumar, N., Ed.; Springer Nature: Singapore, 2024; pp 367– 387.Google reference.7Libenson, A.; Karasaki, S.; Cushing, L. J.; Tran, Rempel, L.; Morello-Frosch, Pace, E. PFAS-Contaminated Pesticides Applied Supply Wells Disproportionately Impact Communities Color California. ES&T Water 4 2495– 2503, 10.1021/acsestwater.3c00845 reference.8Joerss, H.; Freeling, van Leeuwen, Hollender, Liu, X.; Nödler, Wang, Z.; Yu, B.; Zahn, D.; Sigmund, G. (TFA) resources. 193, 109061, 10.1016/j.envint.2024.109061 reference.9Alexandrino, Atlas Reviews Biotechnology 42 991– 1009, 10.1080/07388551.2021.1977234 reference.10Liu, Y.; Sun, Jia, Yue, Yang, Fu, Ye, Novel (2,6-difluorobenzoyl)urea-activated fluorine-containing-pesticide detection. Engineering (3), 112786, 10.1016/j.jece.2024.112786 reference.11Bhat, Pomerantz, W. Arnold, Finding Fluorine: Photoproduct Formation during Photolysis Pesticides. Technol. 56 (17), 12336– 12346, 10.1021/acs.est.2c04242 Scholar11Finding fluorine: photoproduct pesticidesBhat, Akash William A.Environmental Science & Technology 12336-12346CODEN: ESTHAG; ISSN:1520-5851. (American Society) evaluated quantify buffered aq. advanced oxidn. (AOP) redn. (ARP), river water. Simulated sunlight quantum yields pH 7 0.0033, 0.0025, 0.0015, 0.00012 penoxsulam, florasulam, sulfoxaflor, fluroxypyr, resp. bimol. rate consts. hydroxyl radicals 2 5.7 x 1010 M-1 s-1 and, sulfate radicals, 1.6 2.6 108 sulfoxaflor 100-fold lower. Using quant. 19F-NMR, complete obtained. max. fluoride 53.4 87.4% penoxsulam florasulam ARP conditions, 6.1 fluroxypyr AOP conditions. Heteroarom. aliph. photoproducts. Aryl heteroarom. readily defluorinated fluoride. difluoroacetate, 19F-NMR chem. shifts coupling anal. provided information hydrogen loss adjacent bonds changes chirality. Mass spectrometry results consistent obsd. products. will assist selecting agrochems. byproduct formation. ®https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BB38XitFaiu7nJ&md5=697e37bc463631bc935bdcf06cb0b25812Sehgal, Barr, Eick, Invited Perspective: Far Reach PFAS-Inert Adjuvants Pesticide Formulations. 71304, 10.1289/EHP15445 reference.Cited By Click copied!This yet cited publications.Download PDFFiguresReferences Get e-AlertsGet e-AlertsJournal copied!https://doi.org/10.1021/acs.jafc.4c12827Published 2025© permissionsArticle Views-Altmetric-Citations-Learn metrics closeArticle Views COUNTER-compliant sum text downloads since November 2008 (both PDF HTML) institutions individuals. regularly reflect usage leading days.Citations number articles citing article, calculated Crossref daily. Find counts.The Altmetric Attention Score quantitative measure received online. Clicking donut icon load page altmetric.com details score social media article. calculated.Recommended Articles FiguresReferencesAbstractHigh Resolution ImageDownload MS PowerPoint SlideReferences 4Revisiting 387.There 11Finding reference.

Language: Английский

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Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 265, P. 114526 - 114526

Published: Feb. 3, 2025

Language: Английский

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Enhanced removal of PFAS in water using activated ZIF-8 carbons: High adsorption efficiency, repeatable regenerability and reusability

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160192 - 160192

Published: Feb. 1, 2025

Language: Английский

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Per- and polyfluoroalkyl substances in environment and potential health impacts: Sources, remediation treatment and management, policy guidelines, destructive technologies, and techno-economic analysis

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 969, P. 178803 - 178803

Published: Feb. 27, 2025

Language: Английский

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Occurrence of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) in the Transboundary Guarani Aquifer System within a Highly Urbanized Context in the Sinos River Basin

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

The Guarani Aquifer System (GAS) is a transboundary sedimentary aquifer source of public water supply for millions people in Brazil, Argentina, Uruguay, and Paraguay, known the high quality its groundwaters. However, under surface conditions an urban environment with poor sanitation intense industrial activity, can degrade due to input wide range contaminants, including per polyfluoroalkyl substances (PFAS). PFAS are anthropogenic widely used industry their unique properties, such as hydrophobicity chemical stability. environment, they exhibit persistence potential health risks humans other organisms. In this study, 28 were investigated GAS within context Sinos River Basin, located southern region lack sewage treatment, uncontrolled urbanization, strong leather, metallurgical electroplating industries. Fifteen groundwater samples collected from tubular wells springs, five taken River. least two detected, total (ΣPFAS) up 16.78 ng/L, PFOA PFBA being most frequent. waters River, ΣPFAS ranged 0.98 71.09 6:2 FTS PFOSA frequently detected. Our study first one identify background suggests need long-term monitoring aquifer, characteristics may promote retention these highly persistent compounds, likely associated use pesticides leather

Language: Английский

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Per- and polyfluoroalkyl substances contamination of drinking water sources in Africa: Pollution sources and possible treatment methods

Chemosphere, Journal Year: 2024, Volume and Issue: 365, P. 143368 - 143368

Published: Sept. 19, 2024

Language: Английский

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