Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants DOI
Meiyu Zhou, Huilin Zhang,

Qi Xiao

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(23), P. 542 - 546

Published: Jan. 1, 2024

Chlorinated organophosphate flame retardants (Cl-OPFRs) are frequently detected chemicals in the environment and biological samples, yet there is a lack of systematic evaluation regarding adverse effects toxicological mechanisms Cl-OPFRs. This study utilizes outcome pathway (AOP) framework to assess health implications Cl-OPFRs, identifying multi-system toxicity, with particular emphasis on reproductive issues possible toxic mechanisms. These results enhance knowledge hazards linked supporting creation focused risk evaluations suitable regulatory actions.

Language: Английский

Synthetic Antioxidants as Contaminants of Emerging Concern in Indoor Environments: Knowns and Unknowns DOI

Xiaomeng Ji,

Jiefeng Liang,

Yingjun Wang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(51), P. 21550 - 21557

Published: Dec. 12, 2023

Synthetic antioxidants, including synthetic phenolic antioxidants (SPAs), amine (AAs), and organophosphite (OPAs), are essential additives for preventing oxidative aging in various industrial consumer products. Increasing attention has been paid to the environmental contamination caused by these chemicals, but our understanding of is generally limited compared other emerging contaminants such as plasticizers flame retardants. Many people spend a significant portion (normally greater than 80%) their time indoors, meaning that they experience widespread persistent exposure indoor contaminants. Thus, this Perspective focuses on problem The wide application commercial products demonstrated toxicity make them an important family concern. However, knowledge gaps still need be bridged: novel related transformation identified environments, different dust sampling strategies should employed evaluate human contaminants, geographic scope research broadened, partition coefficients among media investigated.

Language: Английский

Citations

49
Microplastics in maternal amniotic fluid and their associations with gestational age DOI

Jiyang Xue,

Zhendong Xu,

Xiao‐Bing Hu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 171044 - 171044

Published: Feb. 19, 2024

Language: Английский

Citations

19
Emerging N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and 6PPD quinone in paired human plasma and urine from Tianjin, China: Preliminary assessment with demographic factors DOI
Chunyu Liu, Xingchen Zhao, Li Guo

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134818 - 134818

Published: June 5, 2024

Language: Английский

Citations

13
Effects of uptake pathways on the accumulation, translocation, and metabolism of OPEs in rice: An emphasis on foliar uptake DOI
Yan Wang, Yingying Jiang,

Yue Xu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170562 - 170562

Published: Feb. 1, 2024

Language: Английский

Citations

8
Association of co-exposure to organophosphate esters and per- and polyfluoroalkyl substances and mixture with cardiovascular-kidney-liver-metabolic biomarkers among Chinese adults DOI Creative Commons
Yanbing Li,

Yi Lv,

Zexuan Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116524 - 116524

Published: June 5, 2024

Organophosphate esters (OPEs) and Per- polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with common exposure sources, leading to their widespread presence in human body. However, evidence on co-exposure OPEs PFAS its impact cardiovascular-kidney-liver-metabolic biomarkers remains limited.

Language: Английский

Citations

8
First Insight into Fetal Exposure to Legacy and Emerging Plasticizers Revealed by Infant Hair and Meconium: Occurrence, Biotransformation, and Accumulation DOI

Fengshan Cai,

Bin Tang, Jing Zheng

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(13), P. 5739 - 5749

Published: March 8, 2024

Epidemiological studies have demonstrated the embryonic and developmental toxicity of plasticizers. Thus, understanding in utero biotransformation accumulation plasticizers is essential to assessing their fate potential early life. In present study, 311 infant hair samples 271 paired meconium were collected at birth Guangzhou, China, characterize fetal exposure legacy emerging metabolites. Results showed that most target detected hair, with medians 9.30, 27.6, 0.145 ng/g for phthalate esters (PAEs), organic phosphate ester (OPEs), alternative (APs), 1.44, 0.313, 0.066 metabolites PAEs, OPEs, APs, respectively. Positive correlations between corresponding primary metabolites, as well among oxidative bis(2-ethylhexyl) (DEHP) 1,2-cyclohexane dicarboxylic acid diisononyl (DINCH), observed, indicating retained major phase-I metabolism While no positive found parent compounds or meconium, significant observed secondary DEHP DINCH suggesting come from hydrolysis fetus but maternal-fetal transmission. The compound/metabolite ratios a decreasing trend across pregnancy, deposition To best our knowledge, this study first report both by using noninvasive biomonitoring matrices provides novel insights into pregnancy.

Language: Английский

Citations

5
Embryonic Exposure to Organophosphate Flame Retardants (OPFRs) Differentially Induces Cardiotoxicity in Rare Minnow (Gobiocypris rarus) DOI
Xiangsheng Hong,

Lilai Yuan,

Xu Zhao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(31), P. 13648 - 13657

Published: July 29, 2024

Organophosphorus flame retardants (OPFRs) such as triphenyl phosphate (TPHP) and tris(1,3-dichloro-2-propyl) (TDCIPP) were reported to impair cardiac function in fish. However, limited information is available regarding their cardiotoxic mechanisms. Using rare minnow (Gobiocypris rarus) a model, we found that both TPHP TDCIPP exposures decreased heart rate at 96 h postfertilization (hpf) embryos. Atropine (an mAChR antagonist) can significantly attenuate the bradycardia caused by TPHP, but only marginally attenuated treatment, suggesting TDCIPP-induced independent of mAChR. Unlike TDCIPP, although TPHP-induced could be reversed transferring larvae clean medium, inhibitory effect AChE activity persisted compared hpf, indicating existence other regulatory Transcriptome profiling revealed cardiotoxicity-related pathways treatments 24 72 hpf embryos/larvae. Similar transcriptional alterations also confirmed hearts adult Further studies verified interfere with Na+/Ca2+ transport lead disorders excitation–contraction coupling larvae. Our findings provide useful clues for unveiling differential mechanisms OPFRs identifying abnormal one select few known factors sufficient fish function.

Language: Английский

Citations

4
Biotransformation, Bioaccumulation, and Bioelimination of Triphenyl Phosphate and Its Dominant Metabolite Diphenyl Phosphate In Vivo DOI

Jing Cao,

Yumeng Lei, Xiaofeng Jiang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(35), P. 15486 - 15496

Published: Aug. 21, 2024

Aryl phosphorus flame retardants (aryl-PFRs), such as triphenyl phosphate (TPHP) and diphenyl (DPHP), are widely used worldwide. Understanding the fates of aryl-PFRs

Language: Английский

Citations

4
Tris(2-chloroethyl) Phosphate Leads to Unbalanced Circulating Erythrocyte in Mice by Activating both Medullary and Extramedullary Erythropoiesis DOI
Jingxu Zhang, Chun‐Feng Liu, Jian Ding

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Tris(2-chloroethyl) phosphate (TCEP), a prevalent organophosphorus flame retardant, has been identified in various environmental matrices and human blood samples, provoking alarm regarding its hematological toxicity, subject that not thoroughly investigated. Red cells (RBCs), or erythrocytes, are the predominant cell type peripheral crucial for maintenance of physiological health. This investigation employed oral gavage to examine effects TCEP exposure on erythrocyte counts mice clarify underlying mechanisms. The results demonstrated marked increase circulating RBC post-TCEP exposure, concomitantly heightening risk polycythemia vera (PV). stimulated erythropoiesis across all stages medullary development, including differentiation hematopoietic stem into erythroid progenitors, progression maturation erythrocyte. Moreover, potentiated extramedullary spleen liver. Subsequent bioinformatics analysis implied TCEP-induced was attributed p53 downregulation. Thus, these findings indicate disrupts erythrocyte-mediated homeostasis through enhancement both erythropoiesis, leading alteration equilibrium.

Language: Английский

Citations

0
New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease DOI Creative Commons
Ting Fang, Qiaoyan Liu,

Xinxin Huangfu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117877 - 117877

Published: Feb. 1, 2025

Diabetic kidney disease is a significant complication of diabetes mellitus, and exposure to certain chemicals may play role in its development. Triphenyl phosphate (TPHP) commonly used plastics flame retardants. This study aims investigate the potential impact TPHP metabolite diphenyl (DPHP) on diabetic using various methods, including network toxicology, molecular docking, cell experiments like CCK8 assay real-time-PCR. The research examined relationship between urinary DPHP levels function American adults data from National Health Nutrition Examination Survey (NHANES) 2017 March 2020. Additionally, explored targets action for toxicity analysis, conducted protein interaction functional aspects through Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment analysis. Furthermore, identified key proteins involved experimental verification by treating cells with DPHP. Toxicity analysis showed that could cause dose-dependent mouse podocyte clone 5 (MPC5) mesangial (MES13). also detected mRNA expression core molecularly docked results indicated statistically regulation most MPC5, MES13, human kidney-2 cells.

Language: Английский

Citations

0