The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities DOI Creative Commons
Haipeng Huang, Jiaqi Hou,

Mingxiao Li

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(4)

Published: Jan. 22, 2025

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.

Language: Английский

Citations

6
Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential DOI
Mengzhu Wang, Peng Zhou, Shane G. DuBay

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137274 - 137274

Published: Jan. 17, 2025

Language: Английский

Citations

4
Microplastics in human skeletal tissues: Presence, distribution and health implications DOI Creative Commons

Qiaoyi Yang,

Peng Ye, Xiaodong Wu

et al.

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109316 - 109316

Published: Feb. 1, 2025

Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs (159.5 103.8 μm) (138.86 105.67 larger that (87.5 30.7 μm). most frequently identified polymers polypropylene (35 %), ethylene vinyl acetate copolymer (30 polystyrene (20 %). vivo experiment suggested invaded through blood circulation after 4 weeks exposure. Serum levels tumor necrosis factor-α (TNF-α), Type Ⅰ procollagen amino-terminal peptide (PINP), tartrate-resistant acid phosphatase-5b (TRACP-5b) elevated compared with control group (p < 0.05). Our study suggests invade supply, causing distinct accumulation these regions. Microplastic invasion can affect health by influencing expression inflammatory morphogenetic cytokines. These findings provide insights into investigating impact on health.

Language: Английский

Citations

3
Discovery and solution for microplastics: New risk carriers in food DOI
Qi Zhang, Xin Wang, Chen Yang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 142784 - 142784

Published: Jan. 1, 2025

Language: Английский

Citations

2
The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Citations

2