Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon DOI Creative Commons
Justin B. Greer, Ellie M. Dalsky, Rachael F. Lane

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(30), P. 10940 - 10950

Published: July 19, 2023

Urban stormwater runoff frequently contains the car tire transformation product 6PPD-quinone, which is highly toxic to juvenile and adult coho salmon (Onchorychus kisutch). However, it currently unclear if embryonic stages are impacted. We addressed this by exposing developing embryos starting at eyed stage three concentrations of 6PPD-quinone twice weekly until hatch. Impacts on survival growth were assessed. Further, whole-transcriptome sequencing was performed recently hatched alevin address potential mechanism 6PPD-quinone-induced toxicity. Acute mortality not elicited in environmentally measured lethal juveniles adults, however, inhibited. Immediately after hatching, sensitive mortality, implicating a large window vulnerability prior smoltification. Molecularly, induced dose-dependent effects that implicated broad dysregulation genomic pathways governing cell–cell contacts endothelial permeability. These consistent with previous observations macromolecule accumulation brains exposed blood–brain barrier disruption as pathway for Overall, our data suggests risk adverse health events upon hatching while indicating mechanism(s) action chemical.

Language: Английский

Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity DOI
Xin Hua, Dayong Wang

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132265 - 132265

Published: Aug. 15, 2023

Language: Английский

Citations

88
Environmental Occurrence and Toxicity of 6PPD Quinone, an Emerging Tire Rubber-Derived Chemical: A Review DOI
Khaled Zoroufchi Benis, Ali Behnami, Shahab Minaei

et al.

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(10), P. 815 - 823

Published: Sept. 1, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a chemical added to tires prevent their oxidative degradation. 6PPD highly reactive with ozone and oxygen, leading the formation of transformation products such as quinone (6PPDQ) on tire surfaces and, subsequently, in road wear particles. 6PPDQ toxicant that has been found roadway runoff receiving water systems. Its presence municipal stormwater led acute mortality coho salmon during migration urban creeks reproduce, generating global interest studying its occurrence toxicity environment. This review aims provide critical overview current state knowledge 6PPDQ, assisting researchers policymakers understanding potential impacts this emerging environment human health. As there are many unanswered questions surrounding further research needed. highlights importance including regulations for 6PPD, well all synthetic chemicals concern.

Language: Английский

Citations

59
Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways DOI
Haoqi Zhao, Sydney P. Thomas, Mark J. Zylka

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(36), P. 13429 - 13438

Published: Aug. 29, 2023

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity 6PPDQ are unknown. Here, we treated C57Bl/6 mice with 4 mg/kg or investigate urine excretion transfer. Female male exhibited sex difference profiles 6PPDQ. Urine concentrations were one order magnitude lower than those 6PPD, suggesting higher bioaccumulation In from embryonic day 11.5 15.5, showed ∼1.5–8 times placenta, embryo body, brain, Using vitro dual-luciferase reporter assays, revealed that activated human retinoic acid receptor α (RARα) retinoid X (RXRα) at as low 0.3 μM, which was ∼10-fold detected urines. RXRα 1.2 μM. These results demonstrate exposure risks during pregnancy emphasize need for further toxicological epidemiological investigations.

Language: Английский

Citations

54
Where the rubber meets the road: Emerging environmental impacts of tire wear particles and their chemical cocktails DOI Creative Commons
Paul M. Mayer, Kelly D. Moran, Ezra Miller

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 171153 - 171153

Published: March 7, 2024

About 3 billion new tires are produced each year and about 800 million become waste annually. Global dependence upon from natural rubber petroleum-based compounds represents a persistent complex environmental problem with only partial often-times, ineffective solutions. Tire emissions may be in the form of whole tires, tire particles, chemical compounds, which is transported through various atmospheric, terrestrial, aquatic routes built environments. Production use generates multiple heavy metals, plastics, PAH's, other that can toxic alone or as cocktails. Used require storage space, energy intensive to recycle, generally have few post-wear uses not also potential sources pollutants (e.g., crumb rubber, pavements, burning). particles emitted during major component microplastics urban runoff source unique highly potent substances. Thus, represent ubiquitous pollutant requires comprehensive examination develop effective management remediation. We approach issue pollution holistically by examining life cycle across production, emissions, recycling, disposal. In this paper, we synthesize recent research data human health risks associated use, disposal discuss gaps our knowledge fate transport, well toxicology leachates. examine remediation approaches for addressing exposure tires. consider three levels: their state, particulates, mixture Finally, information understanding outline key questions improve ability manage remediate pollution.

Language: Английский

Citations

54
Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio) DOI Creative Commons
Nico Grasse, Bettina Seiwert, Riccardo Massei

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(41), P. 15598 - 15607

Published: Oct. 2, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) is a widely used antioxidant in tire rubber known to enter the aquatic environment via road runoff. The associated transformation product (TP) 6-PPD quinone (6-PPDQ) causes extreme acute toxicity some fish species (e.g., coho salmon). To interpret species-specific toxicity, information about biotransformation products of 6-PPDQ would be relevant. This study investigated toxicokinetics and zebrafish embryo (ZFE) model. Over 96 h exposure, accumulated ZFE with concentration factors ranging from 140 2500 for 70 220 6-PPDQ. A total 22 TPs 12 were tentatively identified using liquid chromatography coupled high-resolution mass spectrometry. After exposure 6-PPD, comprised 47% peak area (TPA), 4-hydroxydiphenylamine being most prominent ZFE. Upon >95% taken up was biotransformed, + O glucuronide dominating (>80% TPA). Among other reactive N-phenyl-p-benzoquinone imine found. knowledge this may support studies organisms.

Language: Английский

Citations

53
Occurrence and Fate of Substituted p-Phenylenediamine-Derived Quinones in Hong Kong Wastewater Treatment Plants DOI Creative Commons
Guodong Cao, Wei Wang, Jing Zhang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(41), P. 15635 - 15643

Published: Oct. 5, 2023

-Phenylenediamine quinones (PPD-Qs) are a newly discovered class of transformation products derived from

Language: Английский

Citations

50
Synthetic Antioxidants as Contaminants of Emerging Concern in Indoor Environments: Knowns and Unknowns DOI

Xiaomeng Ji,

Jiefeng Liang,

Yingjun Wang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(51), P. 21550 - 21557

Published: Dec. 12, 2023

Synthetic antioxidants, including synthetic phenolic antioxidants (SPAs), amine (AAs), and organophosphite (OPAs), are essential additives for preventing oxidative aging in various industrial consumer products. Increasing attention has been paid to the environmental contamination caused by these chemicals, but our understanding of is generally limited compared other emerging contaminants such as plasticizers flame retardants. Many people spend a significant portion (normally greater than 80%) their time indoors, meaning that they experience widespread persistent exposure indoor contaminants. Thus, this Perspective focuses on problem The wide application commercial products demonstrated toxicity make them an important family concern. However, knowledge gaps still need be bridged: novel related transformation identified environments, different dust sampling strategies should employed evaluate human contaminants, geographic scope research broadened, partition coefficients among media investigated.

Language: Английский

Citations

49
Widespread occurrence of two typical N, N’-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage DOI
Shiming Song, Yanxia Gao,

Shuai Feng

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133835 - 133835

Published: Feb. 19, 2024

Language: Английский

Citations

39
Occurrence and partitioning of p-phenylenediamine antioxidants and their quinone derivatives in water and sediment DOI
Jianqiang Zhu,

Ruyue Guo,

Fangfang Ren

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 170046 - 170046

Published: Jan. 11, 2024

Language: Английский

Citations

33
First Evidence of the Bioaccumulation and Trophic Transfer of Tire Additives and Their Transformation Products in an Estuarine Food Web DOI

Li-Ni Wei,

Nian-Nian Wu,

Ru Xu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(14), P. 6370 - 6380

Published: March 18, 2024

The discovery of the significant lethal impacts tire additive transformation product N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-Q) on coho salmon has garnered global attention. However, bioaccumulation and trophic transfer additives their products (TATPs) within food webs remain obscure. This study first characterized levels compositions 15 TATPs in Pearl River Estuary, estimated potential 21 estuarine species, identified priority contaminants. Our observations indicated that were prevalent environment. Eight, six, seven, 10 quantified shrimp, sea cucumber, snail, fish samples, with total mean 45, 56, 64, 67 ng/g (wet weight), respectively. N,N′-Diphenyl-p-phenylenediamine (DPPD) N,N′-bis(2-methylphenyl)-1,4-benzenediamine (DTPD) exhibited high bioaccumulation. Significant biodilution was only for benzothiazole, while DPPD DTPD displayed biomagnification trends based Monte Carlo simulations. mechanisms trophodynamics could be explained by chemical hydrophobicity, molecular mass, metabolic rates. Based a multicriteria scoring technique, DPPD, DTPD, 6PPD-Q as work emphasizes importance biomonitoring, particularly specific hydrophobic additives.

Language: Английский

Citations

32