Co-exposure of TMPs and antibiotics in zebrafish: The influence of additives on the risk of hepatotoxicity

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121430 - 121430

Published: March 1, 2025

Language: Английский

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Residues of 6PPD-Q in the Aquatic Environment and Toxicity to Aquatic Organisms: A Review

Fishes, Journal Year: 2025, Volume and Issue: 10(4), P. 146 - 146

Published: March 25, 2025

N-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone (6PPD-Q) is an emerging environmental contaminant that widely distributed in aquatic environments and presents significant toxicological risks to organisms. As 6PPD-Q primarily derived from oxidative transformation of the tire antioxidant N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD), its persistence potential for bioaccumulation organisms have raised widespread concerns. This study reviews sources, spatial distribution, migration, behaviors 6PPD-Q, as well degradation mechanisms different media. Additionally, this review systematically explores effects on organisms, including physiological, biochemical, molecular impacts fish, crustaceans, mollusks, algae, with a focus mechanisms. Finally, we discuss limitations current research propose key directions future studies, long-term ecological risk assessments, bioaccumulation, metabolic pathway analysis, optimization pollution control strategies, aiming provide scientific basis assessment management 6PPD-Q.

Language: Английский

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Spatiotemporal distribution and priority assessment of steroids in the estuarine environment: Implications for environmental risk management

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 216, P. 117980 - 117980

Published: April 18, 2025

Language: Английский

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6PPD-quinone Exposure Induces Oxidative Damage and Physiological Disruption in Eisenia fetida: An Integrated Analysis of Phenotypes, Multi-omics, and Intestinal Microbiota

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 493, P. 138334 - 138334

Published: April 18, 2025

Language: Английский

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Analysis of 6PPD-Q in finfish, shellfish, and marine mammal tissues

Chemosphere, Journal Year: 2025, Volume and Issue: 379, P. 144418 - 144418

Published: April 19, 2025

6PPD-quinone (6PPD-Q), a transformation product of tire rubber anti-oxidant 6PPD, has been identified as the primary causal toxicant for urban runoff mortality syndrome observed in coho salmon (Oncorhynchus kisutch) Pacific Northwest, USA. Several other fish species are also vulnerable to 6PPD-Q. However, monitoring efforts on 6PPD-Q have focused water, particulate matter, soils, and sediments, while that tissues remains scarce. This study presents workflow extraction quantitative analysis complex from shellfish, finfish, marine mammals. A multi-residue protocol was developed persistent organic pollutants (PCBs, PBDEs, organochlorine pesticides) PAHs single extraction. GC-MS/MS based measurement developed. The evaluated including fillets, whole homogenates, mussels, whale blubber. Limits quantification were between 0.03 0.12 ng/g ww surrogate (6PPD-Q-d5) recoveries ∼60-100 % among matrices. We conducted an initial biomonitoring using caged mussels (Mytilus trossulus) juvenile Chinook tshawytscha) Puget Sound, WA. detection rates at least 50 but concentrations mostly <1 ww. Our will aid aquatic environments exposure assessments improved understanding bioaccumulation potential these food webs.

Language: Английский

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Distinct Species-Specific and Toxigenic Metabolic Profiles for 6PPD and 6PPD Quinone by P450 Enzymes: Insights from In Vitro and In Silico Studies

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

The tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone product (6PPDQ) are prevalent emerging contaminants, yet their biotransformation profiles remain poorly understood, hampering the assessment of environmental health risks. This study investigated phase-I metabolism 6PPD 6PPDQ across aquatic mammalian species through in vitro liver microsome (LM) incubations silico simulations. A total 40 metabolites from seven pathways were identified using highly sensitive nano-electrospray ionization mass spectrometry. Notably, was consistently detected as a metabolite with an approximate 2% yield, highlighting neglected indirect exposure pathway for organisms. calculated to form facile two-step phenyl hydroxylation 6PPD, catalyzed by cytochrome P450 enzymes. Distinct species-specific metabolic kinetics observed, fish LM demonstrating retarded rates compared LM, suggesting vulnerability vertebrates these contaminants. Intriguingly, two novel coupled which predicted exhibit elevated toxicity result C–N oxidative coupling P450s. These unveiled offer valuable insights risk 6PPDQ, may inform future studies regulatory actions.

Language: Английский

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Unpuzzling spatio-vertical and multi-media patterns of aniline accelerators/antioxidants in an urban estuary

Water Research, Journal Year: 2024, Volume and Issue: 266, P. 122427 - 122427

Published: Sept. 13, 2024

Language: Английский

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Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

There is growing evidence of the frequent detection tire rubber-derived contaminants

Language: Английский

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Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans

Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125208 - 125208

Published: Oct. 30, 2024

Language: Английский

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Child exposure to N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 153, P. 217 - 228

Published: July 27, 2024

Language: Английский

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