High-Throughput Screening of Polyfluoroalkyl Substances Using Solid-Phase Microextraction Coupled to Microfluidic Open Interface-Mass Spectrometry DOI
Wei Zhou, Malvika Dutt,

Qizhen Lan

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Efficient and sustainable methods for large-scale PFAS monitoring are critical addressing environmental public health challenges. This work presents a high-throughput sample preparation system capable of processing up to 48 samples simultaneously using solid-phase microextraction (SPME) was directly coupled with mass spectrometry (MS) via an automated microfluidic open interface (MOI), bypassing the need chromatographic separation. The SPME-MOI-MS approach achieves sensitive detection 18 in drinking water, limits (LODs) between 1 10 pg/mL, just 1.5 mL average analysis time 2.8 min per sample. SPME blades, employed enhance sensitivity place standard fibers, incorporate matrix-compatible coating material that enables effective screening water as well complex matrices including blood, beer, beef. In addition, significantly low recovery reproducibility nonpolar have been found studied, indicating glass container adding small percentage acetonitrile can address this issue.

Language: Английский

High organofluorine concentrations in municipal wastewater affect downstream drinking water supplies for millions of Americans DOI Creative Commons
Bridger J. Ruyle, Emily H. Pennoyer, Šimon Vojta

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(3)

Published: Jan. 6, 2025

Wastewater receives per- and polyfluoroalkyl substances (PFAS) from diverse consumer industrial sources, discharges are known to be a concern for drinking water quality. The PFAS family includes thousands of potential chemical structures containing organofluorine moieties. Exposures few well-studied PFAS, mainly perfluoroalkyl acids (PFAA), have been associated with increased risk many adverse health outcomes, prompting federal regulations six compounds in 2024. Here, we find that the regulated (mean = 7 8%) 18 measured PFAA 11 21%) make up only small fraction extractable (EOF) influent effluent eight large municipal wastewater treatment facilities. Most EOF (75%) (62%) consists mono- polyfluorinated pharmaceuticals. technology sizes facilities this study similar those serving 70% US population. Despite advanced technologies, maximum removal efficiency among work was <25%. Extrapolating our measurements other across United States results nationwide discharge estimate 1.0 2.8 million moles F y-1. Using national model simulates connections between downstream intakes, sources 23 Americans could contaminated above regulatory thresholds by wastewater-derived alone. These emphasize importance further curbing ongoing additional evaluations fate toxicity fluorinated

Language: Английский

Citations

2
Transforming PFAS management: A critical review of machine learning applications for enhanced monitoring and treatment DOI
Md Hasan-Ur Rahman,

Rabbi Sikder,

Tanvir Ahamed Tonmoy

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 70, P. 106941 - 106941

Published: Jan. 15, 2025

Language: Английский

Citations

0
Groundwater flowpath characteristics drive variability in per- and polyfluoroalkyl substances (PFAS) loading across a stream-wetland system DOI Creative Commons
David M. Rey, Martin A. Briggs, Andrea K. Tokranov

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 964, P. 178533 - 178533

Published: Jan. 24, 2025

Language: Английский

Citations

0
Per- and Poly-Fluoroalkyl Substances, and Organophosphate Flame Retardants in the Upper Yangtze River: Occurrence, Spatiotemporal Distribution, and Risk Assessment DOI Creative Commons
Wen Sun,

Zhiyou Fu,

Yueyue Liu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 116 - 116

Published: Feb. 1, 2025

Contaminants of Emerging Concern (CECs), including per- and polyfluoroalkyl substances (PFASs) organophosphate flame retardants (OPFRs), have raised global concerns due to their persistence, bioaccumulation potential, toxicity. This study presents a comprehensive investigation the occurrence, spatiotemporal distribution, potential sources, ecological human health risks associated with 18 PFASs 9 OPFRs in surface waters upper Yangtze River, China. The water samples were collected from main stream five major tributaries (Min, Jinsha, Tuo, Jialing, Wu Rivers) 2022 2023. total concentration ranged 16.07 927.19 ng/L, 17.36 190.42 respectively, consistently higher observed compared tributaries. Ultra-short-chain (e.g., TFMS) halogenated TCPP) predominant compounds, likely originating industrial discharges, wastewater effluents, other anthropogenic sources. Ecological risk assessments indicated low-to-moderate at most sampling sites, near discharge points. Human evaluations suggested negligible non-carcinogenic but identified carcinogenic OPFR exposure for adults specific locations, particularly Leshan city. highlights importance understanding fate impacts provides valuable insights developing targeted pollution control strategies management measures.

Language: Английский

Citations

0
A High Efficiency Method for the Extraction and Quantitative Analysis of 45 PFAS in Whole Fish DOI
Sarah Balgooyen,

Mary Celine Scott,

Brett R. Blackwell

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

This study describes and validates a new method for extracting perfluoroalkyl polyfluoroalkyl substances (PFAS) from whole-body fish tissue, demonstrates that freeze-dry preservation of tissue conserves bioaccumulative PFAS, details demonstration on Lake Michigan fish. While filets are more commonly analyzed their significance to human health, whole useful determine ecological impacts, but published methods such as EPA 1633 do not produce reliable results this challenging matrix. Here we show lipid removal technology produces clean extracts without the need solid-phase extraction or evaporative concentration, which often lead loss some PFAS. achieves an accuracy 96 ± 9% detection 45 PFAS while also offering benefits simple procedure, reduced processing time, decreased waste generation compared multistep cleanup concentration methods. A test freeze-drying demonstrated compounds detected in Great Lakes were retained, volatile including sulfonamide precursors ethanols lost. To demonstrate field performance, entire was applied whole-fish composites Michigan. Results these samples reveal driven by collection location, distribution dictated species.

Language: Английский

Citations

0
Perfluorinated Carbon Chain Length Drives Uptake of Diverse Per- and Polyfluoroalkyl Substances in Field-Deployed Passive Samplers DOI
Matthew Dunn, Jitka Bečanová, Šimon Vojta

et al.

ACS ES&T Water, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

Citations

0
High-Throughput Screening of Polyfluoroalkyl Substances Using Solid-Phase Microextraction Coupled to Microfluidic Open Interface-Mass Spectrometry DOI
Wei Zhou, Malvika Dutt,

Qizhen Lan

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Efficient and sustainable methods for large-scale PFAS monitoring are critical addressing environmental public health challenges. This work presents a high-throughput sample preparation system capable of processing up to 48 samples simultaneously using solid-phase microextraction (SPME) was directly coupled with mass spectrometry (MS) via an automated microfluidic open interface (MOI), bypassing the need chromatographic separation. The SPME-MOI-MS approach achieves sensitive detection 18 in drinking water, limits (LODs) between 1 10 pg/mL, just 1.5 mL average analysis time 2.8 min per sample. SPME blades, employed enhance sensitivity place standard fibers, incorporate matrix-compatible coating material that enables effective screening water as well complex matrices including blood, beer, beef. In addition, significantly low recovery reproducibility nonpolar have been found studied, indicating glass container adding small percentage acetonitrile can address this issue.

Language: Английский

Citations

0