A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations

Critical Reviews in Toxicology, Journal Year: 2017, Volume and Issue: 48(3), P. 195 - 216

Published: Nov. 24, 2017

This review critically examines the data on claimed endocrine-mediated adverse effects of chemicals wildlife populations. It focuses current-use chemicals, and compares their apparent scale severity with those legacy which have been withdrawn from sale or use, although they may still be present in environment. The concludes that many endocrine activity are generally greater than caused by exception ethinylestradiol other estrogens found sewage effluents, causing widespread fish is considered current chemical testing regimes risk assessment procedures, at least to pesticides biocides subjected, part responsible for this improvement. noteworthy as most ecotoxicological regulatory purposes currently focused characterizing apical effect endpoints rather identifying mechanism(s) any observed effects. Furthermore, a suite internationally standardized ecotoxicity tests sensitive potential now place, under development, should ensure further characterization substances these properties so can adequately regulated.

Language: Английский

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Endocrine disruption in aquatic systems: up‐scaling research to address ecological consequences

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2017, Volume and Issue: 93(1), P. 626 - 641

Published: Aug. 9, 2017

ABSTRACT Endocrine‐disrupting chemicals ( EDCs ) can alter biological function in organisms at environmentally relevant concentrations and are a significant threat to aquatic biodiversity, but there is little understanding of exposure consequences for populations, communities ecosystems. The pervasive nature within environments their multiple sub‐lethal effects make assessments impact especially important also highly challenging. Herein, we review the data on EDC systems focusing studies assessing populations ecosystems, including how biotic abiotic processes may affect, be affected by, responses . Recent research indicates influence behavioural (e.g. enhancing feeding rates), transgenerational trophic cascades ecological exposure. In addition, interactions between other chemical, physical factors generate uncertainty our We illustrate effect thresholds generated from individual‐based experimental bioassays types commonly applied using chemical test guidelines [e.g. O rganisation E conomic C o‐operation D evelopment OECD )] not necessarily reflect hazards associated with endocrine disruption. argue that improved risk assessment ecosystems urgently requires more ecologically oriented as well field‐based population‐, community‐ food‐web levels.

Language: Английский

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Causes and consequences of intraspecific variation in animal responses to anthropogenic noise

Behavioral Ecology, Journal Year: 2019, Volume and Issue: 30(6), P. 1501 - 1511

Published: June 16, 2019

Anthropogenic noise is a recognized global pollutant, affecting wide range of nonhuman animals. However, most research considers only whether pollution has an impact, ignoring that individuals within species or population exhibit substantial variation in responses to stress. Here, we first outline how intrinsic characteristics (e.g., body size, condition, sex, and personality) extrinsic factors environmental context, repeated exposure, prior experience, multiple stressors) can affect stressors. We then present the results systematic search anthropogenic-noise literature, identifying articles investigated intraspecific animals noise. This reveals fewer than 10% (51 589) examining impacts test experimentally for responses; those do, more 75% report significant effects. assess these existing studies determine current scope findings to-date, provide suggestions good practice design, implementation, reporting robust experiments this field. close by explaining understanding anthropogenic crucial improving manage captive animals, monitor wild populations, model responses, mitigate effects on wildlife. Our aim stimulate greater knowledge effective management harmful consequences pollutant.

Language: Английский

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Degradation aspects of endocrine disrupting chemicals: A review on photocatalytic processes and photocatalysts

Applied Catalysis A General, Journal Year: 2020, Volume and Issue: 597, P. 117547 - 117547

Published: April 6, 2020

Language: Английский

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Multigenerational and Transgenerational Effects of Environmentally Relevant Concentrations of Endocrine Disruptors in an Estuarine Fish Model

Environmental Science & Technology, Journal Year: 2020, Volume and Issue: 54(21), P. 13849 - 13860

Published: Sept. 29, 2020

Many pollutants cause endocrine disruption in aquatic organisms. While studies of the direct effects toxicants on exposed organisms are commonplace, little is known about potential for toxicant exposures a parental (F0) generation to affect unexposed F1 or F2 generations (multigenerational and transgenerational effects, respectively), particularly estuarine fishes. To investigate this possibility, we inland silversides (Menidia beryllina) environmentally relevant (low ng/L) concentrations ethinylestradiol, bifenthrin, trenbolone, levonorgestrel from 8 hpf 21 dph. We then measured development, immune response, reproduction, gene expression, DNA methylation two subsequent following exposure. Larval exposure each compound resulted negative F0 generations, ethinylestradiol levonorgestrel, also. The specific endpoints that were responsive varied, but included increased incidence larval deformities, reduced growth survival, impaired function, skewed sex ratios, ovarian atresia, egg production, altered expression. Additionally, fish exhibited differences selected genes, across all three indicating epigenetic transfer effects. These findings suggest assessments multiple key determining full magnitude adverse contaminant early life.

Language: Английский

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Combined effects of increased temperature and endocrine disrupting pollutants on sex determination, survival, and development across generations

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: Aug. 18, 2017

Understanding the combined effects of anthropogenic impacts such as climate change and pollution on aquatic ecosystems is critical. However, little known about how predicted temperature increases may affect activity endocrine disrupting compounds (EDCs), particularly in species with plasticity sex determination. We investigated a concomitant increase exposure to estrogenic EDCs reproduction development an estuarine model organism (Menidia beryllina) across multiple generations. Parents (P) were exposed environmental levels insecticide bifenthrin or ethinylestradiol (EE2) at 22 °C 28 for 14 days prior initiation spawning trials. Embryos F1 generation until 21 post hatch (dph), reared adulthood clean water elevated temperatures, spawned. ratios significantly influenced by EDCs, potentially altering adaptive development. also observed fewer viable offspring increased developmental deformities F2 generations, greater impact juveniles. These findings enhance our understanding responses context demonstrate heritable effects. Our study represents first multigenerational assessment temperatures combination environmentally relevant concentrations commonly detected disruptors vertebrate species.

Language: Английский

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Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates

Journal of Toxicology and Environmental Health Part B, Journal Year: 2017, Volume and Issue: 20(5), P. 276 - 304

Published: July 4, 2017

In vertebrates, sexual differentiation of the reproductive system and brain is tightly orchestrated by organizational activational effects endogenous hormones. mammals birds, period typified a surge sex hormones during specific neural circuits; whereas are dependent upon later increases in these same at maturation. Depending on organ or region, initial programming events may be modulated androgens require conversion to estrogens. The prevailing notion based findings mammalian models that male sculpted undergo masculinization defeminization. absence responses, female develops. While timing vary across taxa, there shared features. Further, exposure different animal environmental chemicals such as xenoestrogens bisphenol A-BPA ethinylestradiol-EE2, gestagens, thyroid hormone disruptors, broadly classified neuroendocrine disrupting (NED), critical periods result similar alterations structure, function, consequently, behaviors. Organizational systems birds appear permanent, teleost fish exhibit plasticity. fewer NED studies amphibians reptiles, data suggest disrupt normal organizational-activational hormones, although it remains determined if disturbances reversible. aim this review examine how various interrupt poikilothermic vertebrates. By altering processes, affect health an compromised populations ecosystem-level effects.

Language: Английский

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Population Dynamics for Conservation

Oxford University Press eBooks, Journal Year: 2019, Volume and Issue: unknown

Published: Sept. 26, 2019

Abstract This book is a quantitative exposition of our current understanding the dynamics plant and animal populations, with goal that readers will be able to understand, participate in management populations wild. The uses mathematical models establish basic principles population behaviour. It begins philosophical approach populations. then progresses from description single variable, abundance, describe changes abundance individuals at each age, similar terms over size, life stage, space. assumes knowledge calculus, but explains more advanced concepts such as partial derivatives, matrices, random signals, it makes use them. basis underlying important processes, mechanism allow persist, rather than go extinct, way which respond variable environments, origin cycles.The next two chapters focus on application manage for prevention extinction, well fisheries sustainable, high yields. final chapter recapitulates how different behaviors arise situations levels density dependence replacement (the potential lifetime reproduction per individual), variability arises time scales set by species’ history.

Language: Английский

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Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish

Environment International, Journal Year: 2019, Volume and Issue: 124, P. 511 - 520

Published: Jan. 26, 2019

Endocrine disruption is one of the consequences industrialization and chemicals released into environment have a profound impact on organisms. Waterborne micromolar concentrations ioxynil (IOX) diethylstilbestrol (DES) in fish affect development heart, vasculature thyroid gland. The present study aimed to determine how IOX DES disrupt crosstalk between developing gland cardio-vascular system zebrafish. Twelve hours post fertilization (hpf) wild type, Tg(fli1:GFP) or Tg(cmalc2:GFPCaaX) zebrafish embryos were exposed 0.1 μM for 36 h (up until 48 hpf) 60 72 hpf). Embryos used vascular endothelial cell sorting, whole-mount immunohistochemistry, tissue selective transcriptomics, selected gene expression analysis by quantitative real-time polymerase chain reaction determination heart rate live imaging. Exposure (0.1 μM) increased beat frequency reduced ventricle volume aorta diameter. transcriptome cells from blood vessels hypertrophic, dilated arrhythmogenic right ventricular cardiomyopathy was significantly changed compound-specific toxic effects found embryos. Both directly affected this indirectly impaired Even though toxicity end-point two similar, their action seemed be via different regulatory pathways physiological mechanisms. cardiovascular there an associated that most likely has long term endocrine axis.

Language: Английский

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Direct and indirect parental exposure to endocrine disruptors and elevated temperature influences gene expression across generations in a euryhaline model fish

PeerJ, Journal Year: 2019, Volume and Issue: 7, P. e6156 - e6156

Published: Jan. 8, 2019

Aquatic organisms inhabiting polluted waterways face numerous adverse effects, including physiological disruption by endocrine disrupting compounds (EDCs). Little is known about how the temperatures associated with global climate change may influence response of exposed to EDCs, and effects that these combined stressors have on molecular endpoints such as gene expression. We Menidia beryllina (inland silversides) environmentally relevant concentrations (1 ng/L) two estrogenic EDCs (bifenthrin 17α-ethinylestradiol; EE2) at 22 °C 28 °C. conducted this experiment over multiple generations better understand potential chronically populations in wild. adult parental fish (F0) for 14 days prior spawning next generation. F1 larvae were then from fertilization until 21 post hatch (dph) before being transferred clean water tanks. reared adulthood, spawned test further exposure offspring (F2 generation). Gene expression was quantified performing qPCR F0 gonads, well F2 larvae. did not detect any significant differences genes measured or gonads. found EE2 treatment significantly decreased nearly all This pattern generation follicle-stimulating hormone receptor (FSHR) gene. Expression 17β-hydroxysteroid dehydrogenase (17β-HSD) G protein-coupled 30 (GPR30) revealed changes previous Effects bifenthrin treatments observed generation, which chemicals indirectly germ cells. Our results indicate their interactions abiotic factors, be adequately represented singular testing. These findings will contribute determination risk EDC contamination contaminated under changing temperature regimes.

Language: Английский

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