Development and Validation of the Particle into Nitroxide Quencher System with BPEAnit Probe for High-Sensitivity Reactive Oxygen Species Detection in Atmospheric Monitoring DOI Creative Commons

Ruiwen Wang,

Jiawen Li, Hao Wang

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(4), P. 1129 - 1129

Published: Feb. 13, 2025

Reactive oxygen species (ROS) play an important role in atmospheric pollution, and their detection is essential for assessing air quality health risks. This study developed validated a standardized methodology using the BPEAnit probe specially designed particle-into-liquid sampler, Particle Into Nitroxide Quencher (PINQ), to measure reactive monitoring applications. The method demonstrated high sensitivity, with limit of 0.03 nmol·m-3, robust linearity (R2 = 0.9999), negligible system residue, ensuring accurate ROS quantification. Comparative analyses startup conditions revealed superior baseline stability under cold start despite longer stabilization time required. auto-oxidation probe, measured at rate 3.01 nmol·m-3 per hour, was identified as critical factor long-term monitoring, highlighting necessity procedures mitigate drift effect. established system's suitability urban assessments public risk evaluations, offering insights into its limitations operational challenges. Future advancements could focus on enhancing expanding method's utility diverse environments, thereby broadening applicability scenarios.

Language: Английский

Oxidative potential associated with water-soluble components of PM2.5 in Beijing: The important role of anthropogenic organic aerosols DOI
Qing Yu, Jing Chen,

Weihua Qin

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 433, P. 128839 - 128839

Published: April 4, 2022

Language: Английский

Citations

47
Are reactive oxygen species (ROS) a suitable metric to predict toxicity of carbonaceous aerosol particles? DOI Creative Commons
Zhihui Zhang, Elena Hartner, Battist Utinger

et al.

Atmospheric chemistry and physics, Journal Year: 2022, Volume and Issue: 22(3), P. 1793 - 1809

Published: Feb. 7, 2022

Abstract. It is being suggested that particle-bound or particle-induced reactive oxygen species (ROS), which significantly contribute to the oxidative potential (OP) of aerosol particles, are a promising metric linking compositions toxicity and adverse health effects. However, accurate ROS quantification remains challenging due short-lived nature many components lack appropriate analytical methods for reliable quantification. Consequently, it difficult gauge their impact on human health, especially identify how particle sources atmospheric processes drive formation in real-world urban environment. In this study, using novel online instrument (OPROSI), we comprehensively characterized compared secondary organic aerosols (SOAs) generated from compounds represent anthropogenic (naphthalene, SOANAP) biogenic (β-pinene, SOAβPIN) precursors. The SOA mass was condensed onto soot particles (SP) under varied atmospherically relevant conditions (photochemical aging humidity) mimic mixing traffic-related carbonaceous primary volatile (VOCs). We systematically analyzed ability aqueous extracts two types (SOANAP-SP SOAβPIN-SP) induce production OP. further investigated cytotoxicity cellular after exposing lung epithelial cell cultures (A549) aerosols. A significant finding study more than 90 % all both have short lifetime, highlighting need develop instruments meaningful ROS. Our results also show photochemical promotes enhances OP Compared SOAβPIN-SP, SOANAP-SP elicited higher acellular production, OP, lower viability. These consistent between chemical-based biological-based analyses indicate could be feasible predict Moreover, caused by exposure not only depends type but affected dose, process deposition cells interactions as realistically possible avoid unknown biases.

Language: Английский

Citations

47
Dynamic Wood Smoke Aerosol Toxicity during Oxidative Atmospheric Aging DOI

Shunyao Wang,

Peter J. Gallimore, Carolyn Liu-Kang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(3), P. 1246 - 1256

Published: Jan. 11, 2023

Wildfires are a major source of biomass burning aerosol to the atmosphere, with their incidence and intensity expected increase in warmer future climate. However, toxicity evolution organic (BBOA) during atmospheric aging remains poorly understood. In this study, we report unique set chemical toxicological metrics BBOA from pine wood smoldering multiphase by gas-phase hydroxyl radicals (OH). Both fresh OH-aged show activity relevant adverse health outcomes. The results two acellular assays (DTT DCFH) significant oxidative potential (OP) reactive oxygen species (ROS) formation BBOA. Also, radical concentrations assessed electron paramagnetic resonance (EPR) spectroscopy increased 50% following heterogeneous aging. This enhancement was accompanied transition predominantly carbon-centered (85%) oxygen-centered (76%) aged aerosols trigger prominent antioxidant defense

Language: Английский

Citations

31
Secondary Organic Aerosol Generated from Biomass Burning Emitted Phenolic Compounds: Oxidative Potential, Reactive Oxygen Species, and Cytotoxicity DOI Creative Commons
Zheng Fang, Alexandra Lai, Dongmei Cai

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(19), P. 8194 - 8206

Published: April 29, 2024

Phenolic compounds are largely emitted from biomass burning (BB) and have a significant potential to form SOA (Phc-SOA). However, the toxicological properties of Phc-SOA remain unclear. In this study, phenol guaiacol were chosen as two representative phenolic gases in BB plumes, water-soluble components their generated under different photochemical ages NOx levels investigated. contribute greatly oxidative (OP) biomass-burning SOA. OH-adducts (e.g., 2-methoxyhydroquinone) identified (GSOA) with high OP. The addition nitro groups 2,5-dimethyl-1,4-benzoquinone, surrogate quinone compound Phc-SOA, increased its toxicity both (PSOA) GSOA vitro human alveolar epithelial cells decreased aging terms cell death cellular reactive oxygen species (ROS), possibly due more ring-opening products relatively low toxicity. influence was consistent between ROS for but not PSOA, indicating that production does necessarily represent all processes contributing caused by PSOA. Combining acellular assays can provide comprehensive understanding aerosol properties.

Language: Английский

Citations

10
Development and Validation of the Particle into Nitroxide Quencher System with BPEAnit Probe for High-Sensitivity Reactive Oxygen Species Detection in Atmospheric Monitoring DOI Creative Commons

Ruiwen Wang,

Jiawen Li, Hao Wang

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(4), P. 1129 - 1129

Published: Feb. 13, 2025

Reactive oxygen species (ROS) play an important role in atmospheric pollution, and their detection is essential for assessing air quality health risks. This study developed validated a standardized methodology using the BPEAnit probe specially designed particle-into-liquid sampler, Particle Into Nitroxide Quencher (PINQ), to measure reactive monitoring applications. The method demonstrated high sensitivity, with limit of 0.03 nmol·m-3, robust linearity (R2 = 0.9999), negligible system residue, ensuring accurate ROS quantification. Comparative analyses startup conditions revealed superior baseline stability under cold start despite longer stabilization time required. auto-oxidation probe, measured at rate 3.01 nmol·m-3 per hour, was identified as critical factor long-term monitoring, highlighting necessity procedures mitigate drift effect. established system's suitability urban assessments public risk evaluations, offering insights into its limitations operational challenges. Future advancements could focus on enhancing expanding method's utility diverse environments, thereby broadening applicability scenarios.

Language: Английский

Citations

1