Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: April 18, 2023
Gastric cancer is one of the top causes cancer-related death globally. Although novel treatment strategies have been developed, attempts to eradicate gastric proven insufficient. Oxidative stress continually produced and present in human body. Increasing evidences show that oxidative contributes significantly development cancer, either through initiation, promotion, progression cells or causing cell death. As a result, purpose this article review role response subsequent signaling pathways as well potential stress-related therapeutic targets cancer. Understanding pathophysiology developing new therapies for depends on more researches focusing contributors carcinogenesis.
Language: Английский
Citations
34
Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108724 - 108724
Published: May 1, 2024
The mass concentration of atmospheric particulate matter (PM) has been continuously decreasing in the Beijing-Tianjin-Hebei region. However, health endpoints do not exhibit a linear correlation with PM concentrations. Thus, it is urgent to clarify prior toxicological components further improve air quality. In this study, we analyzed long-term oxidative potential (OP) water-soluble PM2.5, which generally considered more effective assessing hazardous exposure Beijing from 2018 2022 based on dithiothreitol assay and identified crucial drivers OP PM2.5 online monitoring pollutants, receptor model, random forest (RF) model. Our results indicate that dust, traffic, biomass combustion are main sources Beijing. complex interactions dust particles, black carbon, gaseous pollutants (nitrogen dioxide sulfur dioxide) factors driving evolution, particular, leading abnormal rise 2022. data shows higher observed winter spring compared summer autumn. diurnal variation characterized by declining trend 0:00 14:00 an increasing 23:00. spatial was as lower than Shijiazhuang, while Zhenjiang Haikou, primarily influenced distribution carbon. significance identifying key influencing provide new insights for advancing quality improvement efforts focus safeguarding human
Language: Английский
Citations
11
Current Pollution Reports, Journal Year: 2023, Volume and Issue: 9(3), P. 590 - 601
Published: June 16, 2023
Language: Английский
Citations
19
Chemical Research in Chinese Universities, Journal Year: 2023, Volume and Issue: 39(3), P. 326 - 341
Published: April 29, 2023
Language: Английский
Citations
16
ACS ES&T Air, Journal Year: 2024, Volume and Issue: 1(4), P. 273 - 282
Published: Feb. 21, 2024
Biomass burning brown carbon (BrC) aerosol affects the climate by absorbing light in visible and UV wavelengths, with daytime photochemistry changing its optical properties. Here, aging UVB irradiation of BrC both aqueous particle states was conducted to evaluate conditions mechanism required change ability absorb an emphasis on role radicals oxidation. Photoreactions enhanced absorption O2 present phase particulate states. Deoxygenated samples did not show this enhancement, indicating importance oxidation mechanism. Using furfuryl alcohol as a singlet oxygen (1O2) scavenger, it shown that 1O2 contributes roughly one third increase phase. Conversely, hydroxyl (OH) were demonstrated have no impact. Carbon-centered radicals, measured electron paramagnetic resonance state, formed when but for deoxygenated irradiation. Overall, dependence indicates highly viscous particles, will be atmosphere at low temperatures and/or relative humidity, may experience same degree photochemical more liquid-like particles.
Language: Английский
Citations
5
Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109102 - 109102
Published: Oct. 28, 2024
Language: Английский
Citations
4
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165180 - 165180
Published: June 27, 2023
Language: Английский
Citations
9
Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)
Published: March 8, 2024
Abstract Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity woodsmoke, complex mixture gases, volatile organic compounds, and particulate matter, is commonly studied vitro using isolated exposures conventionally cultured lung cells either resuspended matter or solvent extracts smoke, leading incomplete evaluations. This study aimed improve our understanding woodsmoke inhalation by building an advanced exposure system that emulates human airway epithelium. We report development characterization innovative permits live-cell monitoring intracellular redox status differentiated primary bronchial epithelial at air–liquid interface (pHBEC-ALI) as they are unfractionated generated tube furnace real time. pHBEC-ALI freshly showed oxidative changes were dose-dependent reversible, not attributable carbon monoxide exposure. These findings show utility this novel for studying molecular initiating events underlying woodsmoke-induced physiologically relevant model, its potential provide biological plausibility risk assessment public measures.
Language: Английский
Citations
3
Environmental Science Atmospheres, Journal Year: 2024, Volume and Issue: 4(6), P. 611 - 619
Published: Jan. 1, 2024
Indoor BrC-containing cooking organic aerosols (BrCOA) can act as sensitizers generating the first excited state of molecular oxygen, singlet under indoor lighting conditions. Sustained oxygen steady-state levels lead to prolonged oxidation impacting air quality.
Language: Английский
Citations
3
ACS ES&T Air, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
0