Evaluation of Antioxidant, Anti-inflammatory and Antimicrobial Potential of Aegel marmelos Fruit Pulp Extracts against Clinical Pathogens DOI Creative Commons

A. Saranya,

K Sivakumari,

Rajesh Selvaraj

et al.

International Journal of experimental research and review, Journal Year: 2024, Volume and Issue: 46, P. 58 - 75

Published: Dec. 30, 2024

In India, a wide range of medicinal plants are reported. Since ancient times, these have been used by people for the treatment several diseases. Herbal medicines typically fewer side effects compared to synthetic medicines, and they also non-expensive. The aim this study is evaluate antioxidant, in vitro anti-inflammatory activity through HRBC membrane stabilization, as well antimicrobial potential fruit pulp extracts obtained from Aegle marmelos (A. marmelos). antioxidant was assessed using DPPH assay. Various A. viz., aqueous, chloroform, ethyl acetate, hexane, methanol L-ascorbic acid were found IC50 values 91.168 µg/mL, 153.22 195.58 164.741 µg/mL 39.488 respectively, while (standard) it 57.823 µg/mL. hexane dependent on concentrations. hemp production (IC50) concentration 99.761 114.443 167.423 118.397 23.244 Likewise, demonstrated significant against clinical pathogens. Comparatively, extract showed higher than that other four extracts; contributed significantly development properties. findings study, thus, extract, clearly had strongest when extracts.

Language: Английский

In Vitro and In Vivo Biotransformation Profiling of 6PPD-Quinone toward Their Detection in Human Urine DOI

Man Deng,

Xiaotong Ji,

Bo Peng

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(21), P. 9113 - 9124

Published: May 14, 2024

The antioxidant N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidized quinone product 6PPD-quinone (6PPD-Q) in rubber have attracted attention due to the ecological risk that they pose. Both 6PPD 6PPD-Q been detected various environments humans cohabit. However, date, a clear understanding of biotransformation potential biomarker for exposure are lacking. To address this issue, study presents comprehensive analysis extensive across species, encompassing both vitro vivo models. We tentatively identified 17 metabolites vitro, 15 mice vivo, confirmed presence two human urine samples. Interestingly, different patterns were observed species. Through semiquantitative based on peak areas, we found almost all underwent within 24 h mice, primarily via hydroxylation subsequent glucuronidation. This suggests rapid metabolic processing mammals, underscoring importance identifying effective biomarkers exposure. Notably, monohydroxy 6PPD-Q-O-glucuronide consistently most predominant our studies, highlighting as key epidemiological research. These findings represent first data set mammalian systems, offering insights into pathways involved possible biomarkers.

Language: Английский

Citations

22

Potential human health risk of the emerging environmental contaminant 6-PPD quinone DOI
Wan Xin, Geyu Liang, Dayong Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175057 - 175057

Published: July 26, 2024

Language: Английский

Citations

22

P-phenylenediamine antioxidants and their quinone derivatives: A review of their environmental occurrence, accessibility, potential toxicity, and human exposure DOI

Yuting Liang,

Feng Zhu, Jie Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174449 - 174449

Published: July 3, 2024

Language: Английский

Citations

18

Characterization of Chemical Additives in Daily Clothing Regarding Human Exposure and Environmental Emissions DOI

Xiaomeng Ji,

Jiale Liu, Jie Shen

et al.

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(6), P. 619 - 625

Published: May 17, 2024

Despite the ubiquitous use of textiles, chemical additives used in textile manufacturing, their human exposure, and environmental release have been largely overlooked. Herein, we screened for numerous additives, including synthetic antioxidants, organophosphate esters, phthalate detecting 93 98 chemicals 78 items clothing (sum concentration: 328 to 2.51 × 105 ng/g, median: 2.77 104 ng/g). Compared with esters significantly high concentrations antioxidants (median: ng/g) were found clothes both children adults. Different compositions observed between cotton artificial fabrics, 3 times higher than Dermal contact via sweaty may be a major exposure pathway 2,4-di-tert-butyl-phenol (contributing 39.1% total exposure); thus, it is recommended avoid rewearing minimize exposure. Additionally, emissions through laundry wastewater estimated at 11.2 tons/year China. The discharge 2,6-di-tert-butyl-p-benzoquinone contributed 20.4% input into treatment plants China, indicating non-negligible source this chemical. This work provides comprehensive evidence unwanted underscores necessity continuous monitoring risks associated products.

Language: Английский

Citations

13

Bringing Organophosphate Ester Tris(2,4-di-tert-butylphenyl) Phosphate to the Forefront: A Hidden Threat to the Environment DOI
J. Chen,

Chunzhao Chen,

Jianmin Chen

et al.

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(9), P. 920 - 930

Published: Aug. 13, 2024

Tris(2,4-di-tert-butylphenyl) phosphite (AO168) is a widely utilized organophosphite antioxidant in the field of plastics. Throughout production and usage processes, AO168 can undergo oxidation convert into tris(2,4-di-tert-butylphenyl) phosphate (AO168═O), which has been identified as one novel organophosphate esters (OPEs). AO168═O now extensively present environment, with concentrations generally exceeding those traditional OPEs such triphenyl tri(2-chloroisopropyl) phosphate. Consequently, emerged significant concern that receiving attention from scientific community. However, there exists some controversy regarding formation mechanisms potential risks AO168═O. This Review provides comprehensive overview for first time environmental occurrence, pathways, toxicities, linked to AO168═O, aiming assist researchers policymakers obtaining an unbiased description its impacts on both environment human health. Given numerous unresolved aspects surrounding along wide greater should be devoted this emerging contaminant.

Language: Английский

Citations

6

Identification and Prioritization of Organic Pollutants in Human Milk from the Yangtze River Delta, China DOI
Xin Cheng, Lirong Gao, Xiaoying Cao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(27), P. 11935 - 11944

Published: June 24, 2024

Pollutants in human milk are critical for evaluating maternal internal exposure and infant external exposure. However, most studies have focused on a limited range of pollutants. Here, 15 pooled samples (prepared from 467 individual samples) three areas the Yangtze River Delta (YRD) China were analyzed by gas chromatography quadrupole time-of-flight mass spectrometry. In total, 171 compounds nine types preliminarily identified. Among these, 16 compounds, including 2,5-di-tert-butylhydroquinone 2-tert-butyl-1,4-benzoquinone, detected first time. Partial least-squares discriminant analysis identified ten area-specific pollutants, 2-naphthylamine, 9-fluorenone, 2-isopropylthianthrone, benzo[a]pyrene, among Shanghai (n = 3), Jiangsu Province 6), Zhejiang 6). Risk index (RI) values calculated indicated that legacy polycyclic aromatic hydrocarbons (PAHs) contributed only 20% total RIs PAHs derivatives, indicating more attention should be paid to with various functional groups. Nine priority pollutants YRD The important 4-tert-amylphenol, caffeine, 2,6-di-tert-butyl-p-benzoquinone, which associated apoptosis, oxidative stress, other health hazards. results improve our ability assess risks posed milk.

Language: Английский

Citations

4

Child exposure to N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment DOI
Qingyuan Dai, Qihua Wang, Jing Zhang

et al.

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 153, P. 217 - 228

Published: July 27, 2024

Language: Английский

Citations

4

Presence of N, N’-substituted p-phenylenediamine quinones in Tap Water: Implication for human exposure DOI
Zhijia Miao,

Zhirui Zhao,

Xueqiang Song

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 262, P. 119817 - 119817

Published: Aug. 20, 2024

Language: Английский

Citations

4

Tire Wear Chemicals in the Urban Atmosphere: Significant Contributions of Tire Wear Particles to PM2.5 DOI

Lele Tian,

Shizhen Zhao, Ruiling Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Tire wear particles (TWPs) containing tire chemicals (TWCs) are of global concern due to their large emissions and potential toxicity. However, TWP contributions urban fine poorly understood. Here, 72 paired gas-phase PM

Language: Английский

Citations

4

p-phenylenediamines (PPDs) and PPD-quinones (PPD-Qs) in human urine and breast milk samples: Urgent need for focus on PPD-Qs and the establishment of health threshold criteria DOI
Xiaojun Wu, Ji‐Fan Hu,

Zijiao Yuan

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136176 - 136176

Published: Oct. 15, 2024

Language: Английский

Citations

4