A Highly Chemically Robust 3D Interpenetrated MOF Heterogeneous Catalyst for the Synthesis of Hantzsch 1,4‐Dihydropyridines and Drug Molecules

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 8, 2024

Abstract Metal–organic frameworks (MOFs) have attracted immense attention as efficient heterogeneous catalysts over other solid catalysts, however, their chemical environment instability often limits catalytic potential. Herein, utilizing a flexible unexplored tetra‐acid ligand and employing the mixed approach, 3D interpenetrated robust framework is strategically developed, IITKGP‐51 (IITKGP stands for Indian Institute of Technology Kharagpur), which retained its crystallinity wide range pH solution (4–12). Having ample open metal sites (OMSs), explored catalyst in one‐pot Hantzsch condensation reaction, with low loading broad substrates. The synthesis drug molecules remains one most significant emergent areas organic medicinal chemistry. Considering such practical utility, biologically important Nemadipine B Nifedipine (calcium channel protein inhibitor) are synthesized first time by using this fully characterized via SC‐XRD spectroscopic methods. This report inaugurates usage MOF material molecules.

Language: Английский

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Flexible Hexacarboxylate-Based Cobalt Metal–Organic Framework for the Turn-On/Off Detection of Cr³⁺, Al³⁺, Fe³⁺, and Phenylglyoxylic Acid

Crystal Growth & Design, Journal Year: 2024, Volume and Issue: 24(5), P. 2064 - 2074

Published: Feb. 14, 2024

Two novel cobalt(II)-based metal–organic frameworks (MOFs), namely, {[Co3(TTHA)(bibp)2(H2O)]}n (1) and {[Co2(H2TTHA)(bidpe)2]}n (2) (H6TTHA = 1,3,5-triazine-2,4,6-triamine hexaacetic acid, bibp 4,4′-bis(imidazolyl)biphenyl, bidpe 4,4-bis(imidazoly)diphenyl ether), were hydrothermally prepared based on the mixed ligands strategy fully characterized. Due to rich coordination modes of carboxylic acid ligand, 1 possesses a three-dimensional (3D) structure with two secondary building units ([Co3N3(CO2)4(CO)4] [Co2N2(CO2)4]), whereas 2 exhibits tangled one-dimensional (1D) chain further forms 3D assembled by weak interactions. Interestingly, can serve as an unusual turn-on sensor for detection trivalent metal ions (Al3+, Cr3+, Fe3+) in aqueous solution low limit, shows high-sensitivity fluorescence turn-off behavior toward polystyrene styrene biomarker phenylglyoxylic (PGA). Significantly, effectively sense PGA complicated biological environments. The mechanism study indicated that absorbance-caused enhancement is responsible phenomena induced ions, while occurrence structural collapse leads effect PGA.

Language: Английский

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Two Water-Stable Zn(II) Coordination Polymers as Luminescent Sensors for Detection of Uric Acid in Serum, MnO₄^–, and Cr(VI) Oxo-Anions in Tap Water

Crystal Growth & Design, Journal Year: 2024, Volume and Issue: 24(12), P. 5335 - 5348

Published: May 31, 2024

Two novel coordination polymers (CPs), [Zn2(μ-OH)2(μ-1,5-NDS-κ2O:O′)(μ-Mbimb-κ2N:N′)]n (1) and {[Zn(CH3COO-κ1O)(μ-bbimb-κ2N:N′)1.5](1,5-NDS)0.5}n (2), were synthesized by hydrothermal reaction of Zn(Ac)2·2H2O with 1,5-naphthalenedisulfonate (1,5-NDS2–), 1,4-bis(2-methyl-1H-imidazole-1-yl)butane (Mbimb), or 1,4-bis(1H-benzimidazol-1-yl)butane (bbimb). In the crystal structure 1, Zn(II) centers are connected μ-OH– anions into an infinite –[Zn(OH)]n– chain, which is further linked Mbimb 1,5-NDS2– to form a 3D dia network. 2, bbimb ligands 2D (6,3) brick wall layer Ac– as dangling arms threaded space adjacent layers, resulting in → polythreading structure. Luminescent studies reveal that both CPs have excellent luminescence stability can selectively detect uric acid (UA), MnO4–, Cr(VI) oxo-anions aqueous solutions high quenching efficiency. The limits detection toward UA, CrO42–, Cr2O72– 0.46, 4.33, 5.50, 1.60 μM for CP 1 5.63, 2.84, 7.60, 2.90 respectively. Moreover, two also serve sensors UA serum MnO4– tap water. luminescent films prepared visual naked eye.

Language: Английский

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Advances on silver-based MOFs and/or CPs and their composites: Synthesis strategies and applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215924 - 215924

Published: May 11, 2024

Language: Английский

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Metal-Organic frameworks (MOFs) for Oxo-Anion removal in wastewater Treatment: Advancements and applications

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157396 - 157396

Published: Nov. 1, 2024

Language: Английский

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Mechanistical Insights into the Ultrasensitive Detection of Radioactive and Chemotoxic UO₂²⁺ Ions by a Porous Anionic Co-Metal–Organic Framework

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(22), P. 10403 - 10413

Published: May 18, 2024

Development of a simple, cost-efficient, and portable UO22+ sensory probe with high selectivity sensitivity is highly desirable in the context monitoring radioactive contaminants. Herein, we report luminescent Co-based metal–organic framework (MOF), {[Me2NH2]0.5[Co(DATRz)0.5(NH2BDC)]·xG}n (1), equipped abundant amino functionalities for selective detection uranyl cations. The ionic structure consists two types channels decorated plentiful Lewis basic moieties, which trigger stronger acid–base interaction diffused cationic units thus can selectively quench fluorescence intensity presence other interfering ions. Furthermore, limit sensing was achieved to be as low 0.13 μM (30.94 ppb) rapid responsiveness multiple recyclabilities, demonstrating its excellent efficacy. Density functional theory (DFT) calculations further unraveled preferred binding sites ions tubular channel MOF structure. Orbital hybridization between NH2BDC/DATRz together significantly large electron-accepting ability identified responsible luminescence quenching. More importantly, prepared 1@PVDF {poly(vinylidene difluoride)} mixed-matrix membrane (MMM) displayed good activity comparable 1, great significance their practical employment MOF-based luminosensors real-world application.

Language: Английский

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Highly stable Ni(ii)/Zn(ii)-CPs as multiresponsive luminescent sensors for detection of IO₄⁻, 2,6-dichloro-4-nitrophenol and folic acid

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(31), P. 11982 - 11994

Published: Jan. 1, 2024

This work describes two Ni( ii )/Zn( )-CPs with 3D (4,5)-connected net for 1 and pcu 2, both can serve as multiresponsive luminescent sensors of IO 4 − , 2,6-dichloro-4-nitrophenol folic acid.

Language: Английский

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A Chemically Robust 2D Ni‐MOF as an Efficient Heterogeneous Catalyst for One‐Pot Synthesis of Therapeutic and Bioactive 2‐Amino‐3‐Cyano‐4H‐Pyran Derivatives

ChemSusChem, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Despite possessing numerous catalytic advantages of MOFs, developing 2D frameworks having excellent chemical stability along with new properties remains a grand challenge. Herein, by employing mixed ligand synthetic approach, we have constructed Ni‐MOF, IITKGP‐52 , which exhibits framework robustness in open air, water, as well over wide range aqueous pH solutions (2–12). Benefitting from its and abundant Lewis acidic metal sites (OMSs), is explored catalyzing the heterogeneous three‐component condensation reaction for tandem synthesis bioactive 2‐amino‐3‐cyano‐4H‐pyran derivatives low loading, greater compatibility substrates, recyclability superior efficiency than previously employed homo systems. inaugurates employment MOF‐based catalysts one‐pot therapeutic derivatives.

Language: Английский

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Variation in Catalytic Efficacies of a 2D pH‐Stable MOF by Altering Activation Methods

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Although it is well-known that the Lewis acidity of Metal-Organic Frameworks (MOFs) can effectively enhance their catalytic activity in organic transformations, access to these Lewis-acidic sites remains a key hurdle widespread applications catalysis by MOFs. Easy accessibility strong acidic onto 2D MOFs using proper activation methods be cornerstone attaining desired performance. Herein, we report new chemically stable MOF, IITKGP-60, which displayed excellent framework robustness over wide pH range (2-12). Benefiting from abundant open metal (OMSs) and robustness, developed material was explored one-pot three-component Strecker reaction Knoevenagel condensation reaction. Moreover, catalyst superior catalyzing reactions involving sterically hindered substrate (1-naphthaldehyde) with high turnover number. A comparative study conducted different (chloroform methanol exchanged activated samples), highlighting significant effect on its performances. The sustainable synthetic pathway under solvent-free conditions for broad scope substrates low loading recyclability made pH-stable promising heterogeneous catalyst.

Language: Английский

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Highly Water‐Stable 2D MOF as Dual Sensor for the Ultra‐Sensitive Aqueous Phase Detection of Nitrofuran Antibiotics and Organochlorine Pesticides

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Misuse of antibiotics and pesticides has led to hazardous effects on human health, livestock, agriculture, aquaculture, which urges researchers find simple, rapid, efficient, cost‐effective methods for quick on‐site analysis these organic pollutants with functional materials. Herein, a 2D chemically robust MOF: IITKGP‐71 , {[Cd(MBPz)(2,6‐NDC)]·2H 2 O} n is strategically developed ease in scalability exploited as dual sensors toward the toxic antibiotic pesticide detection via luminescence quenching aqueous medium . The framework displays exceptional chemical robustness water 3 months, an open atmosphere over wide range pH solution (pH = 3–12) day. can selectively quench nitrofuran (NFZ NFT) organochlorine DCN while remaining unaffected by other interfering pesticides, respectively. An excellent trade‐off between high effectivity (high K sv ) sensitivity (low LOD) was achieved targeted analytes. easy scalability, stability, fast responsivity, multi‐responsive nature, recyclability outstanding structural stability made this viable playing crucial role safeguarding aquatic ecosystems public health from pesticides.

Language: Английский

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