Red and NIR light-triggered enhancement of anticancer and antibacterial activities of dinuclear Co(ii)-catecholate complexes

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Photoactive complexes of bioessential 3d metals, activable within the phototherapeutic window (650-900 nm), have gained widespread interest due to their therapeutic potential. Herein, we report synthesis, characterization, and light-enhanced anticancer antibacterial properties four new dinuclear Co(II) complexes: [Co(phen)(cat)]2 (Co-1), [Co(dppz)(cat)]2 (Co-2), [Co(phen)(esc)]2 (Co-3), [Co(dppz)(esc)]2 (Co-4). In these complexes, phen (1,10-phenanthroline) dppz (dipyrido[3,2-a:2',3'-c]phenazine) act as neutral N,N-donor ligands, while cat2- esc2- serve O,O-donor catecholate ligands derived from catechol (1,2-dihydroxybenzene) esculetin (6,7-dihydroxy coumarin). Their high-spin paramagnetic nature dimeric identity in solution were confirmed by magnetic susceptibility, UV-visible, emission, mass spectral data. Co-1-Co-4 exhibited an absorption band 600-850 nm range, originating a charge transfer transition. The electrically demonstrated sufficient stability both dark under irradiated conditions. Co-2 Co-4 notable toxicity towards A549 lung carcinoma cells, with potency increasing significantly brief (5 min) exposure 660 (red) 808 (NIR) laser light (IC50 ∼ 8.9 14.9 μM). Notably, normal NIH-3T3 fibroblast cells was minimal. Cellular assays highlighted that induced cell death followed apoptotic pathway, primarily mitochondrial damage. also significant against Gram-(+) S. aureus Gram-(-) P. aeruginosa, effectiveness enhanced upon irradiation (MIC 15-142 increase efficacies attributed generation cytotoxic singlet oxygen (1O2) species red/NIR exposure. NIR produced more pronounced effects compared nm. This study is first on cobalt exhibiting red light-triggered enhancement activities, illuminating path for development long-wavelength absorbing efficacy.

Language: Английский

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Exploring the potential of ruthenium(ii)–phosphine–mercapto complexes as new anticancer agents

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(26), P. 10947 - 10960

Published: Jan. 1, 2024

The search for new metal-based anticancer drug candidates is a fundamental task in medicinal inorganic chemistry. In this work, we assessed the potential of two Ru(II)-phosphine-mercapto complexes as agents. complexes, with formula [Ru(bipy)(dppen)(Lx)]PF

Language: Английский

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Investigation on photophysical and photochemical properties of Ir and Ru complexes featuring sulfurated pyridine-1,2,3-triazole based ligands

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117423 - 117423

Published: Jan. 1, 2025

Language: Английский

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Subcellular Photocatalysis Enables Tumor-Targeted Inhibition of Thioredoxin Reductase I by Organogold(I) Complexes

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Selective inhibition of TrxR1 over TrxR2 is a highly sought-after goal, because the two enzymes play distinct roles in cancer progression. However, achieving targeted challenging due to their high homology and identical active site sequence. Herein we report new subcellular photocatalysis approach for by controllably activating organogold(I) prodrugs within cytosol, exclusive location TrxR1. The NHC-Au(I)-alkynyl complexes are stable evenly distributed cell; they can meanwhile be efficiently transformed into NHC-Au(I)-L species (L = labile ligands) via radical mechanism photocatalysts released cytosol (from endosome/lysosome) upon light irradiation, leading selective without affecting TrxR2. This results strong cytotoxicity cells with much higher selectivity than auranofin, pan TrxR inhibitor that cannot discriminate TrxR1/2, along potent antitumor activities multiple zebrafish mouse models. prodrug activation may thus suggest novel precision targeting using remarkable spatial control photocatalysis.

Language: Английский

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Serendipitous crossed aldol reaction in the second coordination sphere of a Ru(II) polypyridyl complex in silica bed: prospect for delivering anticancer agents for photoactivated chemotherapy

Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This work provides a simple new strategy to design Ru( ii ) polypyridyl-based photoactivated chemotherapeutic agents via the attachment of ‘uncageable’ anticancer based on serendipitous crossed aldol reaction in ligand periphery.

Language: Английский

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