ROS are universal cell-to-cell stress signals

Current Opinion in Plant Biology, Journal Year: 2024, Volume and Issue: 79, P. 102540 - 102540

Published: April 21, 2024

Language: Английский

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DSF-family quorum sensing signal-mediated intraspecies, interspecies, and inter-kingdom communication

Trends in Microbiology, Journal Year: 2022, Volume and Issue: 31(1), P. 36 - 50

Published: Aug. 5, 2022

DSFs are cis-2-unsaturated fatty acids containing acid carbon chains of various lengths and cis double-bond configurations. DSF-producing bacteria widely distributed in nature.Based on their genomic origins, DSF-mediated intraspecies communication pathways generally affiliated to three different groups, respectively represented by Xanthomonas campestris pv. (Xcc), Burkholderia cenocepacia (Bcc), Pseudomonas aeruginosa.DSF-mediated interspecies occurs between B. cenocepacia, Stenotrophomonas maltophilia, Bacillus, Francisella novicida, Salmonella, Bdellovibrio bacteriovorus.DSF-mediated inter-kingdom Candida albicans.DSF signaling plant development defense, Xylella fastidiosa colonization insects, the zebrafish inflammatory response. While most unicellular microbes they communicate with each other environments adapt behaviors. Quorum sensing (QS) is one best-studied cell–cell modes. QS not restricted bacterial cell-to-cell – it also allows eukaryotic hosts. The diffusible signal factor (DSF) family represents an intriguing type multiple roles found diverse Gram-negative bacteria. Over last decade, extensive progress has been made understanding among bacteria, fungi, plants, zebrafish. This review provides update these new developments aim building a more comprehensive picture intraspecies, interspecies, communication. Microbes ubiquitous populate plants animals, as well soil, water, air. They form communities multitude environments. It becoming increasingly apparent that isolated specific but rather interact surroundings [1.Thompson L.R. et al.The Earth microbiome project consortium. A communal catalogue reveals Earth's multiscale microbial diversity.Nature. 2017; 551: 457-463Crossref PubMed Scopus (1204) Google Scholar]. One key challenges microbiology dissect diversity, metabolic activities, interactions within community associated (see Glossary), process whereby monitor population density regulate gene expression using chemical signals, [2.Leoni L. al.Leoni Rampioni G. Sensing Methods Protocols. Humana Press, 2017: 1-4Google widespread eubacteria, archaea, fungi. Research recent decades identified rich inventory signals QS-regulated beneficial or competitive Recent evidence shows limited hosts [3.Hughes D. al.Inter-kingdom signaling: hosts.Nat. Rev. Microbiol. 2008; 6: 111-120Crossref (550) Scholar, 4.Hartmann A. al.Importance N-acyl-homoserine lactone-based quorum quenching pathogen control growth promotion.Pathogens. 2021; 10: 1561Crossref (8) 5.Fan Q. al.Structure regulation mechanism interkingdom system receptors.J. Agric. Food Chem. 2022; 70: 429-445Crossref (7) Understanding mechanisms outcomes signal-mediated important implications for appreciating host–pathogen and, ultimately, may provide targets strategies antimicrobial therapies block interfere networks. [6.Deng Y. al.Listening language: DSF-based bacteria.Chem. 2011; 111: 160-173Crossref (191) Scholar,7.Zhou DSF signals: biosynthesis, turnover Xanthomonas.Trends 25: 293-303Abstract Full Text PDF (121) Recently, reported [8.Tran T.M. hijacks Arabidopsis thaliana sterol biosynthesis suppress innate immunity.Life Sci. Alliance. 2020; 3e202000720Crossref 9.Ma Z. al.Formin nanoclustering-mediated actin assembly during flagellin signaling.Cell Rep. 34108884Abstract (15) 10.Zhu H. al.Bacterial inhibits LPS-induced inflammations suppressing Toll-like receptor preventing lysosome mediated apoptosis zebrafish.Int. J. Mol. 23: 7110Crossref (1) More detailed descriptions structures, biological functions, can be previous reviews Scholar,11.He Y.W. al.Quorum virulence campestris.FEMS 32: 842-857Crossref (200) 12.Dow J.M. Diffusible factor-dependent pathogenic its exploitation disease control.J. Appl. 2016; 122: 2-11Crossref (32) 13.Wang M. cis-2-dodecenoic (BDSF) cenocepacia.Appl. Environ. 88e0234221Crossref (4) For convenience, will used collective term DSF-family unless otherwise specified. first discovered was cis-11-methyl-dodecenoic (XcDSF) phytopathogen (Xcc). Subsequently, several analogs, (BDSF), cis, cis-11-methyldodeca-2,5-dienoic (CDSF), cis-10-methyl-2-dodecenoic (IDSF), 13-methyltetradecanoic (LeDSF), cis-2-tetradecenoic (XfDSF1), cis-2-hexadecenoic (XfDSF2), cis-2-decenoic (PDSF), have identified. Except LeDSF, all configurations (Figure 1). Until now, members detected range species belonging γ-proteobacteria β-proteobacteria including spp., fastidiosa, Lysobacter enzymogenes brunescens, Leptospirillum ferri philum ferrooxidans, Cronobacter turicensis, aeruginosa [7.Zhou Scholar,14.An S.Q. al.Diffusible regulates functions opportunistic maltophilia.BMC Res. Notes. 2018; 11: 569Crossref (16) 15.Li (DSF)-mediated modulates traits citri responses citrus promote disease.BMC Genomics. 2019; 20: 55Crossref (24) 16.Feng T. al.Interspecies synergistically twitching motility.Appl. 85e01742Crossref (12) 17.Ling al.LbDSF, brunescens quorum-sensing factor, anti- XSAC colony morphology, surface motility.Front. 1230Crossref 18.Alcaraz E. rpf/DSF signalling maltophilia positively biofilm formation, production virulence-associated factors β-lactamase induction.FEMS Lett. 366fnz069Crossref (18) 19.Yero al.Genetic variants influence resistance phenotypes genotypically clinical isolates.Front. 1160Crossref (11) 20.Bellenberg S. controls bioleaching activity niche protection acidophilic, mineral-oxidizing Leptospirilli.Sci. 16275Crossref (5) 21.Singh P. synthase, RpfF, oryzae required maintenance membrane integrity virulence.Mol. Plant Pathol. 118-132Crossref In silico analysis suggests Methylobacillus flagellates, Thiobacillus denitrificans, genera Frateuria, Luteibacter, Pseudoxanthomonas, Rhodanobacter produce DSF. By definition, individuals same species. helps sense size degree confinement, allowing them function multicellular organism execute broad Based Xcc, aeruginosa. distinguished presence 'regulation pathogenicity factors' (rpf) cluster encoding components such synthase RpfF perception RpfC/RpfG functionally verified phytopathogens X. strains environmental relevance spp. [14.An Scholar,16.Feng Bacteria this through classic synthesis pathway final bifunctional enzyme, having both dehydratase thioesterase activities [22.Zhou synthesized from carbohydrate branched-chain amino via FAS elongation cycle.Sci. 2015; 5: 13294Crossref (55) However, strictly regulated growth. whole QS-dependent comprises stages: pre-QS, QS, post-QS, Xcc At pre-QS stage, cell density-dependent autoinduced protein–protein interaction mechanism. sensor RpfC forms complex receiver domain [23.He al.Dual hybrid kinase involve either phosphorelay domain–protein interaction.J. Biol. 2006; 281: 33414-33421Abstract (99) post-QS RpfB-dependent induced levels return those stage [24.Zhou al.Identification characterization naturally occurring Xanthomonas.Environ. 17: 4646-4658Crossref (41) Scholar] 2A ). perceived transduced two-component comprising response regulator RpfG. activated HD-GYP RpfG phosphodiesterase degrade second messenger cyclic-di-GMP, ligand global cyclic AMP receptor-like protein (Clp), which, turn, directly indirectly [25.He al.Xanthomonas cell-cell involves putative nucleotide Clp hierarchical network.Mol. 2007; 64: 281-292Crossref (157) Scholar,26.Tao F. monophosphate defines class di-GMP effectors.J. Bacteriol. 2010; 192: 1020-1029Crossref (148) Activated shown two GGDEF domain-containing proteins motility [27.Ryan R.P. al.Cell-cell signal-dependent dynamic mediate campestris.Proc. Natl. Acad. U. 107: 5989-5994Crossref (117) addition, negatively aggregate ABC (xagABC)-dependent formation [28.Tao modulation glycosyltransferase essential formation.Environ. 12: 3159-3170Crossref (60) 2B). Interestingly, atypical RpfF/RpfC-regulated were (Xoo) strain BXO43 [29.Rai R. promotes ferric iron uptake oryzicola contribute inside rice.Mol. 96: 708-727Crossref (20) Scholar,30.Ionescu al.Promiscuous responsiveness rpf System.mBio. 7e01054Crossref (31) These findings suggest category I might than what current models suggest. pathogens, biofilm, multidrug resistance, integrity, [15.Li Scholar,21.Singh Scholar,31.He al.Genome scale regulon campestris: identification novel communication-dependent genes functions.Mol. 59: 610-622Crossref (150) Scholar,32.Barel V. al.Virulence planta movement hortorum pelargonii affected (DSF)-dependent system.Mol. 16: 710-723Crossref (13) soil bacterium Lysobacter, LeDSF antibiotics pigment, [16.Feng Scholar,17.Ling acidophilic Leptospirilli [20.Bellenberg characterized rpfF homolog rpfFBC rpfR, BDSF cepacia (Bcc) genus [33.Deng al.Structural functional produced complex.Appl. 76: 4675-4683Crossref (95) Scholar,34.Suppiger al.Evidence molecules aid biosensors.Environ. 8: 38-44Crossref major II system, RqpS/RqpR, modulating rpfFBc transcription [35.Cui C. al.A cenocepacia.Mol. 108: 32-44Crossref (26) recently reviewed [13.Wang RpfR Per/Arnt/Sim (PAS), GGDEF, EAL domain. binds PAS RpfR, causing conformation change. change plays critical role regulating thereby influencing intracellular cyclic-di-GMP [36.Waldron E.J. basis recognition regulatory RpfF.PLoS 17e3000123Crossref able bind [34.Suppiger regulator, GtrR, interacts cepI, acyl homoserine lactone (AHL)-type [37.Yang al.Burkholderia integrates dimeric guanosine virulence.Proc. 114: 13006-13011Crossref (43) link AHL-dependent underlining complexity signaling. drug-resistant produces DSF-type molecule PDSF. PDSF attributed dspI (PA0745), located PA0743–PA0747 PAO1 [38.Amari D.T. enoyl-coenzyme hydratase DspI dispersion autoinducer acid.J. 2013; 195: 4600-4610Crossref (46) another cluster, PA4978–PA4983, suggested involved [39.Rahmani-Badi al.Dissection network microarray technique.Front. 383PubMed induce PA14 Microarray revealed dispersion, motility, virulence, persistence PA14, PDSF-deficiency provoked remarkable reduction pyoverdine production, swarming [40.Liu studies DspI: biosynthesis.Sci. 3928Crossref (19) transduction remains elucidated. Given PDSF-regulated mostly overlap signaling, likely never live alone natural ecosystems physically trophically other. detect only self-produced neighbors [41.Coquant al.(2020) Impact lactones, molecules, gut immunity.Front. Immunol. 1827; 2020: 11Google prodigious diversity nature, surprising enormous repertoire occurs. aeruginosa, multidrug-resistant pathogens. Chronic infection occur 80% cystic fibrosis (CF) patients, who often coinfected fungus Aspergillus sp. [42.Hughes D.A. al.Clinical characteristics co-infected patients: UK registry study.J. Cyst. Fibros. 21: 129-135Abstract As described previously, PDSF, BDSF, XcDSF, respectively, mediate, order, III, II, maltophilia–P. cocultures, influences architecture biofilm. requires PA1396 [43.Ryan polymyxin tolerance aeruginosa.Mol. 68: 75-86Crossref (179) Mutation exogenous addition XcDSF results increased stress suggesting sensed Further, at physiologically relevant concentrations sputum samples CF patients infected Bcc [44.Twomey K.B. airway modulate aeruginosa.ISME 2012; 939-950Crossref (78) correlated polymicrobial infections involving and/or together When inoculated intratracheally into transmembrane conductance (CFTR) knockout mice, observed lung Furthermore, could biofilms human CF-derived epithelial cells vitro culture system. Addition significantly enhanced biofilms. [45.Deng al.Cis-2-dodecenoic interference systems T3SS.BMC 13: 231Crossref Exogenous decreases transcriptional level lasR, rhlR, pqsR leading reduced AHL quinolone (PQS) III secretion (T3SS) micromolar reduces HeLa models. PA1396, long-chain PsrA. Instead, appeared inhibit T3SS alternative independent Taken together, clearly operate lungs

Language: Английский

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ROS are evolutionary conserved cell-to-cell stress signals

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(31)

Published: July 26, 2023

Cell-to-cell communication is fundamental to multicellular organisms and unicellular living in a microbiome. It thought have evolved as stress- or quorum-sensing mechanism organisms. A unique cell-to-cell that uses reactive oxygen species (ROS) signal (termed the “ROS wave”) was identified flowering plants. This process essential for systemic signaling plant acclimation stress can spread from small group of cells entire within minutes. Whether similar found other however unknown. Here, we report ROS wave be algae, amoeba, ferns, mosses, mammalian cells, isolated hearts. We further show this triggered by local H 2 O treatment blocked application catalase NADPH oxidase inhibitors algae it communicates important stress–response signals between cells. Taken together, our findings suggest an active signaling, like wave, before diverged. could communicated environmental coordinated response many different community. The finding process, contributes understanding diseases impact development drugs target example cancer heart disease.

Language: Английский

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Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Feb. 13, 2024

Abstract Aeromonas species (spp.) are well-known fish pathogens, several of which have been recognized as emerging human pathogens. The organism is capable causing a wide spectrum diseases in humans, ranging from gastroenteritis, wound infections, and septicemia to devastating necrotizing fasciitis. systemic form infection often fatal, particularly patients with underlying chronic diseases. Indeed, recent trends demonstrate rising numbers hospital-acquired especially immuno-compromised individuals. Additionally, -associated antibiotic resistance an increasing challenge combating both infections. acquisition related ’ innate transformative properties including its ability share plasmids integron-related gene cassettes between the environment. As result, alternatives treatments desperately needed. In that vein, many proposed studied extensively fish-farming industry, target quorum sensing. this review, we discuss current strategies targeting sensing inhibition propose such studies empower development novel chemotherapeutic approaches combat drug-resistant spp. infections humans. Key points • notoriously acquires maintains antimicrobial resistance, making treatment options limited. Quorum essential virulence mechanism Inhibiting can be effective strategy animals

Language: Английский

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A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 5, 2025

Quorum sensing, first described in marine systems five decades ago, is a well-characterized chemical communication system used to coordinate bacterial gene expression and behavior; however, the impact of quorum sensing on interkingdom interactions has been vastly understudied. In this review, we examine how these molecules mediate between bacteria eukaryotes; influencing processes such as development, disease pathogenesis, microbiome regulation within ecosystems. We describe varied mechanisms eukaryotes have evolved interfere with signaling, crucial role signals play host-virus interactions, their exchange may be governed by outer membrane vesicles, prevalent systems. Here, present dynamic portrayal beyond communication, laying groundwork for future investigations roles shaping ecosystem structure function. A review examines system, shapes eukaryote

Language: Английский

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Chlamydomonas reinhardtii, a Reference Organism to Study Algal–Microbial Interactions: Why Can’t They Be Friends?

Plants, Journal Year: 2023, Volume and Issue: 12(4), P. 788 - 788

Published: Feb. 9, 2023

The stability and harmony of ecological niches rely on intricate interactions between their members. During evolution, organisms have developed the ability to thrive in different environments, taking advantage each other. Among these organisms, microalgae are a highly diverse widely distributed group major primary producers whose with other play essential roles habitats. Understanding basis is crucial control exploit communities for biotechnological applications. green microalga Chlamydomonas reinhardtii, well-established model, emerging as model organism studying wide variety microbial economic significance. In this review, we unite discuss current knowledge that points C. reinhardtii interactions.

Language: Английский

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Cooperation of quorum sensing and central carbon metabolism in the pathogenesis of Gram-positive bacteria

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127655 - 127655

Published: Feb. 21, 2024

Language: Английский

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Aptamer-based therapy for fighting biofilm-associated infections

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 522 - 539

Published: Feb. 3, 2024

Biofilms are key players in the pathogenesis of most chronic infections associated with host tissue or fluids and indwelling medical devices. These hard to be treated due increased biofilms tolerance towards antibiotics comparison planktonic (or free living) cells. Despite advanced understanding their formation physiology, continue a challenge there is no standardized therapeutic approach clinical practice eradicate them. Aptamers offer distinctive properties, including excellent affinity, selectivity, stability, making them valuable tools for purposes. This review explores flexibility designability aptamers as antibiofilm drugs but, importantly, targeting diverse drug delivery systems. It highlights specific examples application species according different modes action inhibition motility adhesion, blocking quorum sensing molecules, dispersal biofilm-cells state. Moreover, it discusses limitations challenges that impaired an success use on biofilm management, well opportunities related modifications can significantly expand applicability field.

Language: Английский

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AI-2 quorum sensing-induced galactose metabolism activation in Streptococcus suis enhances capsular polysaccharide-associated virulence

Veterinary Research, Journal Year: 2024, Volume and Issue: 55(1)

Published: June 17, 2024

Abstract Bacteria utilize intercellular communication to orchestrate essential cellular processes, adapt environmental changes, develop antibiotic tolerance, and enhance virulence. This communication, known as quorum sensing (QS), is mediated by the exchange of small signalling molecules called autoinducers. AI-2 QS, regulated metabolic enzyme LuxS (S-ribosylhomocysteine lyase), acts a universal mechanism across gram-positive gram-negative bacteria crucial for diverse bacterial processes. In this study, we demonstrated that in Streptococcus suis ( S. ), notable zoonotic pathogen, QS enhances galactose utilization, upregulates Leloir pathway capsular polysaccharide (CPS) precursor production, boosts CPS synthesis, leading increased resistance macrophage phagocytosis. Additionally, our molecular docking dynamics simulations suggest that, similar pneumoniae , FruA, fructose-specific phosphoenolpyruvate phosphotransferase system prevalent pathogens, may also function an membrane surface receptor . conclusion, study significance synthesis metabolism-dependent conducted preliminary analysis potential role FruA AI-2.

Language: Английский

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Coumarins: Quorum Sensing and Biofilm Formation Inhibition

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4534 - 4534

Published: Sept. 24, 2024

Quorum sensing (QS) is a bacterial cell-to-cell communication mechanism that plays an essential role in pathogenesis. QS governs behavior and controls biofilm formation, which turn contributes to antibiotic resistance. Therefore, identifying synthesizing novel compounds overcome inhibit formation are essential. Coumarins important plant-derived natural products with wide-ranging bioactivities extensive applications, including antibacterial, antifungal, anticoagulant, antioxidant, anticancer, anti-inflammatory properties. Additionally, coumarins capable of rewiring inhibition, leading higher susceptibility antimicrobial agents less this review, we aim provide overview formation. This review also discusses the synthesized controlling QS, inhibiting inducing synergy antibiotic–coumarin combinations. Hence, emphasizes potential coumarin act as antibacterial demonstrates their ability alleviate

Language: Английский

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