Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 2, 2023
The
gut
microbiota
not
only
constitutes
intestinal
microenvironment
homeostasis
and
human
health
but
also
exerts
indispensable
roles
in
the
occurrence
progression
of
multiple
liver
diseases,
including
alcohol-related
disease,
nonalcoholic
fatty
autoimmune
disease
cancer.
Given
therapeutic
status
these
their
prevention
early
therapy
are
crucial,
detailed
mechanism
urgently
needs
to
be
explored.
Meanwhile,
studies
have
shown
that
various
traditional
Chinese
medicines,
such
as
Si
Miao
Formula,
Jiangzhi
Granules,
Liushen
Capsules,
Chaihu-Shugan
Power,
Cassiae
Semen
Gynostemma,
well
some
natural
products,
Costunolide,
Coprinus
comatus
polysaccharide,
Antarctic
krill
oil,
Oridonin
Berberine,
can
repair
injury,
improve
liver,
regulate
immunity,
even
inhibit
cancer
through
targets,
links,
pathways.
Intriguingly,
aforementioned
effects
demonstrated
by
medicines
products
been
closely
related
microbiota,
directly
driving
strategy
one
breakthroughs
treatment
diseases.
Based
on
this,
this
review
comprehensively
summarizes
discusses
characteristics,
functions
potential
mechanisms
targeting
during
treatment.
Research
regulatory
medicine
provides
novel
insights
significant
references
for
developing
strategies.
In
parallel,
explorations
will
enhance
comprehension
modulating
treatment,
thus
facilitating
clinical
investigation
application.
Egyptian Liver Journal,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 29, 2023
Abstract
Background
Natural
bioactive
components
derived
from
plant
secondary
metabolites
have
been
pronounced
as
valuable
alternatives
for
anticipating
and
subsiding
hepatotoxic
effects
its
chronic
complications
based
on
experimental
verification.
The
focus
of
this
review
is
to
elucidate
the
commonly
used
modern
medicine
treatment
liver
disease
how
major
phytoconstituents
tested
hepatoprotective
activity,
mechanism
action
some
promising
agents
natural
sources,
clinical
trial
data
treating
in
patients
with
different
diseases
by
aid
phytoconstituents.
Main
text
shows
fifteen
isolated
phytoconstituents,
their
biological
chemical
structures,
utilized
parts,
type
extracts
used,
assay
method,
possible
hepatoprotection.
Nine
leads
sources
chemistry
are
mentioned
briefly.
further
includes
recent
studies
outcome
patients.
Scientific
revealed
that
antioxidant
properties
central
subside
pathways
upsurging
defense
system
cells,
scavenging
free
radicals,
down
surging
lipid
peroxidation,
improving
anti-inflammatory
potential,
protecting
hepatic
cell
injury.
In
review,
we
summarize
development
product-based
curative
potential
various
sort
diseases.
Furthermore,
usefulness
hit
lead
molecules
significant
benefit
discover
new
drug
molecule
downsizing
problems
medication
chemical-induced
extrapolated.
Conclusion
Further
research
encouraged
pharmacological
principle
these
natural-based
which
will
stimulate
future
pharmaceutical
therapeutically
beneficial
regimens.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 31, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
a
major
chronic
in
contemporary
society,
affected
by
N6-methyladenosine
(m6A)
RNA
methylation,
one
of
the
most
common
modifications.
Compared
with
healthy
control,
m6A
methyltransferase
3
(METTL3)
and
METTL14
increased,
while
Wilms
tumor
1-associated
protein
(WTAP)
RNA-binding
motif
15
(RBM15)
decreased
significantly
NAFLD,
demethylases
fat
mass
obesity-associated
(FTO)
elevated.
Meanwhile,
binding
proteins,
YT521-B
homology
(YTH)
domain-containing
1
(YTHDC1),
YTHDC2,
insulin-like
growth
factor
2
mRNA
(IGF2BP1),
heterogeneous
nuclear
ribonucleoprotein
C
(HNRNPC),
HNRNPA2B1
were
decreased,
eukaryotic
translation
initiation
subunit
H
(EIF3H)
was
increased
significantly.
All
these
changes
regulators
had
significant
differences
between
control
but
no
NAFL
NASH
group.
The
expression
level
RBM15,
HNRNPC,
related
to
body
index.
HNRNPA2B1,
EIF3H
steatosis.
Also,
KIAA1429
YTH
domain
family
(YTHDF1)
lobular
inflammation.
Taken
together,
involved
occurrence
NAFLD.
More
importantly,
abnormal
MYC
determined
as
key
link
regulation
higher
accompanied
HDL
cholesterol
unsaturated
acid
proportions,
well
lower
mass,
glucose,
transaminase.
dysregulation
methylation
caused
steatosis
fibrosis,
affecting
might
be
its
potential
target.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25053 - e25053
Published: Jan. 23, 2024
Abstract
Background
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
prevalent
chronic
condition
with
significant
clinical
implications.
Emerging
research
indicates
endoplasmic
reticulum
(ER)
stress
as
critical
pathogenic
factor
governing
inflammatory
responses,
lipid
metabolism
and
insulin
signal
transduction
in
patients
NAFLD.
ER
stress-associated
activation
of
multiple
pathways,
including
the
unfolded
protein
response,
disrupts
homeostasis
substantially
contributes
to
NAFLD
development
progression.
Targeting
for
function
enhancement
presents
an
innovative
therapeutic
strategy.
Notably,
natural
bioactive
compounds
plant
extracts
have
shown
potential
treating
by
reducing
level
marker
proteins
mitigating
inflammation,
de
novo
lipogenesis.
However,
owing
limited
comprehensive
reviews,
effectiveness
pharmacology
these
remain
uncertain.
Objectives
To
address
abovementioned
challenges,
current
review
categorizes
chemical
structures
properties
into
flavonoids,
phenols,
terpenoids,
glycosides,
lipids
quinones
examines
their
ameliorative
under
stress.
Methods
This
systematically
analyses
literature
on
interactions
from
molecular
targets
stress,
providing
holistic
view
therapy.
3 Biotech,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: Jan. 13, 2025
Abstract
This
study
investigated
the
ameliorative
effects
of
Yinchen
lipid-lowering
tea
(YCLLT)
on
Non-alcoholic
fatty
liver
disease
(NAFLD),
specific
mechanism
involved
was
also
studied.
We
modeled
hepatocellular
steatosis
with
HepG2
cells
and
intervened
different
concentrations
YCLLT-containing
serum.
Lipid
deposition
assessed
by
oil
red
O
staining
AdipoR1
expression
analyzed
Western
blot.
The
hepatocyte
model
further
treated
serum
and/or
silencing
AdipoR1.
observed
staining.
Flow
cytometry
used
to
detect
apoptosis
mitochondrial
membrane
potential.
levels
TNF-α,
IL-6,
MDA,
8-OHdG,
ATP
were
ELISA
or
corresponding
kits.
structure
transmission
electron
microscopy.
AdipoR1/AMPK/SIRT1
signaling
pathway
factors
blot,
co-localization
SIRT1
immunofluorescence.
results
revealed
that
YCLLT
attenuated
lipid
deposition,
inhibited
inflammatory
TNF-α
reduced
MDA
up-regulated
content
potential,
promoted
AdipoR1,
p-LKB1,
p-AMPKα,
SIRT1,
PGC-1a
in
a
cellular
NAFLD.
Further,
effect
NAFLD
cell
model.
Altogether,
attenuates
improving
function
via
activating
AdipoR1/AMPK/
signaling.
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
rapidly
emerging
as
a
global
health
crisis,
affecting
over
30%
of
the
population
and
demanding
urgent
attention.
This
redefined
condition,
previously
known
non-alcoholic
fatty
(NAFLD),
reflects
deeper
understanding
intricate
interplay
between
metabolic
dysfunction
health.
At
heart
MASLD
lies
troubling
accumulation
triglycerides
(TGs)
in
hepatocytes,
which
precipitates
insulin
resistance
oxidative
stress,
ultimately
leading
to
more
severe
forms
like
steatohepatitis
(MASH).
Excitingly,
recent
research
has
spotlighted
farnesoid
X
receptor
(FXR)
groundbreaking
therapeutic
target.
FXR
not
only
regulates
lipid
metabolism
but
also
combats
inflammation
resistance,
making
it
potential
game-changer
fight
against
MASLD.
With
one
FDA-approved
drug,
resmetirom,
currently
available,
exploration
agonists
opens
new
avenues
for
innovative
treatments
that
could
revolutionize
patient
care.
By
harnessing
power
restore
balance
integrating
advanced
strategies
lipidomics
acid
profiling,
we
stand
on
brink
transforming
how
approach
its
associated
complications,
paving
way
healthier
future.
review
delves
into
promising
role
combating
implications
related
disorders,
emphasizing
urgency
detect
manage
this
burgeoning
epidemic.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(29), P. 25521 - 25531
Published: July 12, 2022
Gardeniae
fructus
(GF),
the
fruit
from
Gardenia
jasminoides
Ellis,
is
a
traditional
Chinese
medicine
used
for
treatment
of
nonalcoholic
fatty
liver
disease
(NAFLD)
in
clinic.
To
explore
hepatoprotective
mechanism
GF
NAFLD,
we
proposed
novel
strategy
that
integrated
vivo
efficacy
evaluation,
network
pharmacology
analysis,
molecular
docking,
and
experimental
validation.
A
NAFLD
animal
model
induced
by
high
fat
diet
(HFD)
feed
was
established,
then
orally
administrated
with
or
without
GF.
The
results
showed
significantly
decreased
levels
serum
total
cholesterol
(TC),
lipoprotein
cholesterol,
triglyceride
(TG),
alanine
aminotransferase,
aspartate
lactate
dehydrogenase,
free
acids,
glucose,
insulin
TG,
TC,
malondialdehyde
compared
nontreated
HFD
group.
Network
studies
quercetin,
oleanolic
acid,
kaempferol,
geniposide
were
main
biocompounds
targeted
PPARα
PPARγ
genes
through
regulating
PPAR
AMPK
signal
pathways
to
protect
against
NAFLD.
interactions
between
bioactive
compounds
their
corresponding
target
proteins
analyzed
docking
subsequently
confirmed
using
qRT-PCR
assay.
Collectively,
therapeutic
drug
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(30), P. 34328 - 34341
Published: July 20, 2022
To
date,
few
effective
treatments
have
been
licensed
for
nonalcoholic
fatty
liver
disease
(NAFLD),
which
a
kind
of
chronic
disease.
Mammalian
sterile
20-like
kinase
1
(MST1)
is
reported
to
be
involved
in
the
development
NAFLD.
Thus,
we
evaluated
suitability
redox-unlockable
polymeric
nanoparticle
Hep@PGEA
vector
deliver
MST1
or
siMST1
(HCP/MST1
HCP/siMST1)
NAFLD
therapy.
The
can
efficiently
condensed
functional
nucleic
acids
into
NAFLD-affected
mouse
upregulate
downregulate
expression.
HCP/MST1
complexes
significantly
improved
insulin
resistance
sensitivity
and
reduced
damage
lipid
accumulation
by
AMPK/SREBP-1c
pathway
without
significant
adverse
events.
Instead,
HCP/siMST1
delivery
exacerbates
analysis
patient
samples
further
clarified
role
hepatic
steatosis
patients
with
MST1-based
gene
intervention
considerable
potential
clinical
therapy,
provides
promising
option
