Heliyon,
Journal Year:
2024,
Volume and Issue:
10(10), P. e31197 - e31197
Published: May 1, 2024
Electroacupuncture
(EA)
is
an
effective
alternative
for
the
treatment
of
functional
dyspepsia
(FD).
It
reduces
low-grade
duodenal
inflammation
and
improves
symptoms
FD
by
downregulating
expression
NF-κB
p65
NLRP3,
but
its
mechanism
needs
to
be
elucidated.
To
examine
regulatory
effect
electroacupuncture
on
intestinal
flora
p65/NLRP3
pyroptosis
pathway
in
rats.
The
rat
model
was
established
via
multi-factor
stress
intervention
two
weeks.
rats
were
randomly
divided
into
NC
group,
NF-kB
inhibitor
group
(NF-κB
BAY
11–7082
administered),
EA
+
group.
After
14
days
treatment,
sacrificed,
protein
mRNA
levels
p65,
IκB,
NLRP3
duodenum
evaluated
Western
blotting
assays
real-time
fluorescent
quantitative
PCR.
Illumina
MiSeq
sequencing
platform
used
analyze
V4
region
16S
rRNA
gene
predict
genes.
concentration
short-chain
fatty
acids
(SCFAs)
feces
assessed
metabolomics.
can
decrease
promote
gastrointestinal
motility
This
mediated
inhibition
pathway,
increase
alpha
beta
diversity
gut
microbiota
duodenum,
abundance
beneficial
bacteria
at
phylum
genus
levels,
content
SCFAs.
protective
against
might
involve
multiple
hierarchy
pathways.
may
remodel
inhibiting
thereby
improving
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(2), P. 1219 - 1236
Published: Feb. 1, 2024
Drug-induced
liver
injury
(DILI)
is
a
disease
that
remains
difficult
to
predict
and
diagnose,
the
underlying
mechanisms
are
yet
be
fully
clarified.
The
gut–liver
axis
refers
reciprocal
interactions
between
gut
liver,
its
homeostasis
plays
prominent
role
in
maintaining
health.
It
has
been
recently
reported
patients
animals
with
DILI
have
disrupted
axis,
involving
altered
microbiota
composition,
increased
intestinal
permeability
lipopolysaccharide
translocation,
decreased
short-chain
fatty
acids
production,
impaired
bile
acid
metabolism
homeostasis.
present
review
will
summarize
evidence
from
both
clinical
preclinical
studies
about
of
pathogenesis
DILI.
Moreover,
we
focus
attention
on
potential
therapeutic
strategies
for
based
improving
function,
including
herbs
phytochemicals,
probiotics,
fecal
microbial
transplantation,
postbiotics,
acids,
Farnesoid
X
receptor
agonists.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Feb. 9, 2024
Autoimmune
hepatitis
(AIH)
is
a
chronic
inflammatory
disease
of
the
liver
that
mediated
by
autoimmunity
and
has
complex
pathogenesis.
Its
prevalence
increased
globally.
Since
first
organ
to
be
exposed
harmful
substances,
such
as
gut-derived
intestinal
microbiota
its
metabolites,
gut
health
closely
related
health,
"liver-gut
axis"
allows
abnormalities
in
influence
development
liver-related
diseases
AIH.
Changes
composition
resultant
disruption
barrier
microbial
transport
are
involved
multiple
ways
immune
homeostasis
inflammation,
thereby
influencing
In
terms
mechanisms
immune,
or
which
decreased
secondary
bile
acids,
short-chain
fatty
acids
(SCFAs),
polyamines,
lipopolysaccharide
(LPS),
branched-chain
amino
(BCAA),
tryptophan
metabolite,
acid,
can
disrupt
activating
various
cells
immune-related
signaling
pathways,
resulting
aberrant
activation
system.
Clarifying
this
mechanism
significant
clinical
implications
for
treatment
AIH
with
drugs
target
pathways.
Therefore,
narrative
review
summarizes
progress
exploring
involvement
pathogenesis
AIH,
aim
helping
improve
precise
targeting
therapeutic
treatments
against
benefit
treatment.
Journal of Asian Natural Products Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: Jan. 10, 2025
Angoroside
C
(AgrC)
is
a
compound
with
many
pharmacological
properties.
However,
its
antitumour
potential
has
not
been
well
studied.
The
low
bioavailability
of
AgrC
suggests
strong
link
to
gut
bacteria.
Therefore,
we
identified
and
quantified
four
metabolites
in
microbiota.
Molecular
docking
inhibitor-based
experiments
demonstrated
that
carboxylesterase
played
key
role
metabolism.
Both
inhibited
the
viability
CT-26
cells,
targets
were
further
explored.
Additionally,
significantly
increased
levels
propionic,
butyric,
valeric
isovaleric
acids.
This
provides
new
insight
for
effects
AgrC.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Numerous
studies
have
shown
that
hyperlipidaemia
is
closely
related
to
the
gut
microbiota,
and
study
of
microbiota
in
treatment
undoubtedly
a
new
target
for
prevention
hyperlipidaemia.
The
efficacy
regulating
microecology
changing
structure
flora
has
been
demonstrated
by
both
western
traditional
medication,
biological
therapy,
dietary
exercise,
so
it
particularly
important
relationship
between
In
this
review,
we
summarize
mechanism
pathogenesis
influencing
various
modalities,
which
provides
diversified
therapeutic
ideas
scientific
basis
clinical
treatment.
It
also
triggers
us
think
about
other
diseases,
explore
influence
goal
still
need
explore.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 30, 2025
Introduction
Polygonatum
kingianum
is
a
well-known
medicinal
herb
with
proven
bioactivities;
however,
little
known
about
the
effects
of
its
polysaccharide
on
intestinal
injuries
in
animals
induced
by
lipopolysaccharide
(LPS).
Methods
A
total
30
Institute
Cancer
Research
(ICR)
mice
were
divided
into
control
(CH),
(MH),
and
treated
(H)
groups.
Mice
group
H
supplemented
100
mg/kg
polysaccharides,
while
groups
C
M
same
amount
normal
saline
gavage
for
18
days.
On
th
day
LPS
(10
mg/kg).
Results
The
results
showed
weight
MH
significantly
dropped
(
P
<
0.0001),
PK
had
higher
0.01).
Pathological
analysis
found
that
majority
villi
broken
short,
PK-treated
longer
considerably
integrated
villi.
length
CH
0.0001)
was
than
M,
value
length/crypt
depth
smaller
crypt
0.0001).
Serum
inspection
MAD
0.05),
IL-1β
IL-6
TNF-α
0.01)
MH,
SOD
0.001),
T-AOC
0.01),
GSH-Px
notably
H.
Microbiome
sequencing
obtained
844,477
raw
725,469
filtered
reads.
There
2,407
ASVs
detected
animals,
there
312
328
shared
between
H,
respectively.
5
phyla
20genera
remarkable
bacteria
among
including
genera
Escherichia,
Pseudomonas_E,
Mailhella,
Paramuribaculum
,
NM07-P-09,
Odoribacter,
Nanosyncoccus
SFM01,
Onthenecus,
Clostridium_Q
UBA6985,
Ructibacterium
UBA946,
Lachnoclostridium_B,
Evtepia
CAG-269,
Limivicinus,
Formimonas,
Dehalobacterium,
Dwaynesavagella
UBA6985.
We
revealed
could
alleviate
promoting
oxidation
resistance,
decreasing
inflammatory
responses,
accommodating
microbiota
mice.
Discussion
Our
suggest
possibility
developing
novel
therapies
diseases.
World Journal of Gastroenterology,
Journal Year:
2025,
Volume and Issue:
31(9)
Published: Feb. 18, 2025
In
the
contemporary
medical
landscape,
burgeoning
interest
in
natural
therapies,
particularly
for
managing
gastrointestinal
disorders,
has
brought
traditional
Chinese
medicine
(TCM)
to
forefront.
This
article
explains
core
principles
and
clinical
applications
of
TCM
treating
these
conditions,
furthering
discourse
through
an
examination
integrated
strategies,
as
demonstrated
study
by
Zhou
et
al.
While
shown
promising
outcomes,
it
encounters
significant
hurdles
standardization,
mechanistic
research,
validation.
Future
investigations
should
aim
solidify
scientific
underpinnings
expand
its
use
disease
management,
striving
a
seamless
fusion
practices.
ABSTRACT
Aims
The
TiaoGanXiaoZhi
formula
(TGXZ),
a
traditional
Chinese
medicine,
has
been
shown
to
alleviate
the
progression
of
metabolic‐associated
fatty
liver
disease
(MAFLD)
clinically.
However,
its
underlying
mechanism
remains
unclear.
This
study
aimed
investigate
effects
and
mechanisms
TGXZ
in
treating
MAFLD
mouse
models.
Methods
model
was
established
using
high‐fat
diet
5%
fructose
water
over
16
weeks.
At
Week
8,
mice
exhibited
significant
steatosis,
inflammation,
insulin
resistance.
A
total
42
were
divided
into
normal
feed
(NFD)
group
(
n
=
18)
(HFD)
24).
Six
from
each
killed
at
8
for
serological
histopathological
assessments.
remaining
allocated
NFD
6),
HFD
+
Placebo
6)
groups.
(or
placebo)
administered
clinical
equivalent
dose
7.699
g/(kg·d)
respective
groups,
while
groups
received
distilled
water.
Daily
gavage
started
9.
16,
after
fasting,
body
weight
condition
recorded,
euthanized
with
pentobarbital
sodium.
Liver
tissue
collected
further
analysis,
feces
stored
−80°C.
Data
graphed
GraphPad
Prism
8.0.0
analyzed
SPSS
Statistics
25.0.
Results
are
expressed
as
mean
±
standard
deviation.
Statistical
comparisons
made
Student's
t
‐test
two
one‐way
ANOVA
more
than
significance
set
p
<
0.05.
Compared
group,
treatment
significantly
downregulated
white
adipose
(1.61
0.66
vs.
3.06
0.34
g,
0.0010),
(1.22
0.16
1.98
0.39
0.0031),
levels
alanine
aminotransferase
(20.6
3.4
46.1
12.3
U/L,
aspartate
(99.9
19.1
168.4
34.3
0.0014),
cholesterol
(2.95
0.56
4.38
mmol/L,
0.0053),
triglycerides
(2.25
0.41
4.18
0.67
low‐density
lipoprotein
(0.66
0.11
1.41
0.52
0.0073),
bile
acid
(0.71
2.18
0.61
0.0017),
except
high‐density
(2.41
0.81
2.55
0.31
0.5655).
transcriptome,
fecal
microbiota
sequencing,
lipidomics
analysis
demonstrated
that
improved
expression
genes
related
lipid
metabolism,
alleviated
intestinal
disorders,
mitigated
disturbances
caused
by
MAFLD.
Conclusions
Our
effectively
inhibitory
on
may
be
attributed
regulation
gut
microbiota,
hepatic
inflammation.
