Mycotoxins in Feed: Hazards, Toxicology, and Plant Extract-Based Remedies

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 219 - 219

Published: March 24, 2025

Background: Mycotoxins, which are secondary metabolites produced by fungi, prevalent in animal feed and pose a serious risk to the healthy growth of livestock poultry. Methods: This review aims conclude current knowledge on detrimental effects mycotoxins health demonstrate potential plant extracts as means counteract mycotoxin toxicity feed. A systematic literature was conducted identify studies impact poultry health, well research into use additives mitigate effects. Studies were selected based their relevance topic, data extracted regarding mechanisms action efficacy extracts. Results: Excessive can lead reduced appetite, impaired digestion, general issues animals, resulting decreased food intake, slowed weight gain, instances acute poisoning. Plant with antioxidant, anti-inflammatory, anti-mutagenic properties have shown improve production efficiency reduce toxic mycotoxins. Conclusion: comprehensive not only consolidates well-documented adverse but also introduces novel perspective highlighting promising natural solution toxicity.

Language: Английский

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Multi-omics reveals the protective effects of curcumin against AFB1-induced oxidative stress and inflammatory damage in duckling intestines

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 276, P. 109815 - 109815

Published: Dec. 5, 2023

Language: Английский

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Quercetin dietary supplementation protects against difenoconazole-induced carp spleen inflammatory damage via regulating ROS/NF-κB/NLRP3 inflammasome axis

Aquaculture, Journal Year: 2023, Volume and Issue: 579, P. 740162 - 740162

Published: Sept. 28, 2023

Language: Английский

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Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and Pyroptosis

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 5729 - 5754

Published: Dec. 1, 2023

Background: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases. However, underlying molecular mechanisms its pathogenesis are unknown. This study aimed to identify biomarkers ferroptosis and pyroptosis in RA screen potential drugs. Methods: The RA-related differentially expressed genes (DEGs) GSE55235 were screened by R software intersected with gene libraries obtain ferroptosis-related (DEFRGs) pyroptosis-related (DEPRGs). We performed Gene Ontology (GO), Kyoto Encyclopedia Genome (KEGG), ClueGO, Protein-Protein Interaction (PPI) analysis for DEFRGs DEPRGs validated them machine learning. microRNA/transcription factor (TF)-hub regulatory network was further constructed. key using GSE77298 validation set, cellular vitro experiments, immune infiltration CIBERSORT. Network pharmacology used find gene-targeting drugs, followed docking dynamics simulations analyze binding stability between small-molecule drugs large-molecule proteins. Results: Three hub (CASP8, PTGS2, JUN) via bioinformatics, (CASP8) obtained through diagnostic efficacy verified be excellent receiver operating characteristic (ROC) curves. phenotypes constructed fibroblast-like synoviocytes (FLS), caspase-8 detected as a biomarker RA, quercetin can reduce levels. Quercetin found target drug pharmacology, their simulations. Conclusion: Caspase-8 an important therapy targeting pyroptosis. Keywords: rheumatoid arthritis, ferroptosis, pyroptosis, caspase-8,

Language: Английский

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Leydig cells pyroptosis in testis mediates deoxynivalenol-induced male reproductive toxicity in mice

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176432 - 176432

Published: Sept. 21, 2024

Language: Английский

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