Siweixizangmaoru Decoction Ameliorated Type II Collagen-Induced Arthritis in Rats <i>via</i> Regulating JAK2–STAT3 and NF-κB Signaling Pathway DOI Open Access

Yanfei Niu,

Qianjing Feng,

Mingxue Cui

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 47(9), P. 1511 - 1524

Published: Sept. 12, 2024

Siweixizangmaoru decoction (SXD) is widely used as an anti-rheumatoid arthritis (RA) in Tibet, however, the specific anti-inflammatory mechanism of SXD still unclear. This research attempts to examine efficacy and possible mechanisms treating RA. The primary chemical components were identified using UHPLC-Q-Exactive Orbitrap MS. We established a lipopolysaccharide (LPS)-induced RAW264.7 macrophage inflammatory injury model explore validated it through vivo experiments. According our vitro well vivo, exhibits qualities. can suppress nitric oxide (NO) pro-inflammatory factor production cells activated by LPS. underlying this effect might be connected janus tyrosine kinase 2-signal transducer activator transcription 3 (JAK2/STAT3) nuclear factor-κB (NF-κB) signaling pathways. In alleviates joint swelling, decreases generation factors serum, lowers oxidative stress, improves damage. short, degeneration symptoms associated with RA regulating inflammation via suppression NF-κB JAK2/STAT3 pathway activation.

Language: Английский

Caspase-8 in inflammatory diseases: a potential therapeutic target DOI Creative Commons

Wangzheqi Zhang,

Chenglong Zhu,

Yan Liao

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 8, 2024

Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for regulatory role in extrinsic apoptosis. With advancing research, growing body of evidence has substantiated involvement other cell death processes, such as pyroptosis and necroptosis, well modulatory effects on inflammasomes proinflammatory cytokines. PANoptosis, an emerging concept death, encompasses pyroptosis, apoptosis, providing insight into the often overlapping cellular mortality observed during disease progression. The activation or deficiency caspase-8 enzymatic activity is closely linked to positioning key regulator survival across various physiological pathological processes. Aberrant expression associated with development progression range inflammatory diseases, including immune system disorders, neurodegenerative diseases (NDDs), sepsis, cancer. This paper delves impact these conditions, aiming elucidate potential therapeutic strategies future intervention.

Language: Английский

Citations

10
Contemporary insights and prospects on ferroptosis in rheumatoid arthritis management DOI Creative Commons
Hongyu Zhao, Qiumei Dong, Hao Hua

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 24, 2024

Rheumatoid arthritis (RA) is a common autoimmune disease characterized primarily by persistent synovial inflammation and joint destruction. In recent years, ferroptosis, as novel form of cell death, has garnered widespread attention due to its critical role in various diseases. This review explores the potential mechanisms ferroptosis RA relationship with pathogenesis RA, systematically analyzing regulatory cells, chondrocytes, immune cells. We emphasize evaluation ferroptosis-related pathways their therapeutic targets, including development application inhibitors activators. Although shows some promise treatment, dual safety issues clinical still require in-depth study. Future research should focus on elucidating specific pathology developing more effective safer strategies provide new treatment options for patients.

Language: Английский

Citations

4
Nanodrug delivery systems targeting ferroptosis as an innovative therapeutic approach for Rheumatoid Arthritis DOI Creative Commons

Xiaolin Dai,

Yu‐Jun Zheng,

J. J. Cui

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101804 - 101804

Published: April 25, 2025

Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, progressive cartilage degradation, and bone erosion. Recent research has implicated ferroptosis not only in autoimmune hepatitis but also the pathogenesis progression of disorders like RA. Consequently, numerous therapeutic strategies have begun to target pathway, particularly design development nanodrug delivery systems (NDDSs). While previous reviews comprehensively discussed mechanisms ferroptosis, related signaling pathways, NDDS materials, recent studies further elucidated interplay between various metabolic providing robust theoretical basis for NDDS-based strategies. This review focuses on investigating role RA, aiming elucidate how targeting can offer novel concepts potential treatments RA patients. Specifically, it summarizes ferroptosis-based NDDSs via different pathways highlights feasibility treatment regimens based mechanism. Furthermore, critically discusses current limitations offers perspectives future directions this field.

Language: Английский

Citations

0
Nanometer preparation of natural bioactive compounds for treatment of rheumatoid arthritis DOI Creative Commons

Junping Zhu,

Xiang Qin, Qi Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101341 - 101341

Published: May 1, 2025

Language: Английский

Citations

0
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? DOI Open Access

Shania Bieri,

Burkhard Möller, Jennifer Amsler

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8212 - 8212

Published: July 27, 2024

Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation lipid peroxides. In this review, we summarize research on impact ferroptosis disease models and isolated cells in various types arthritis. While most studies have focused rheumatoid arthritis (RA) osteoarthritis (OA), there limited spondylarthritis crystal arthropathies. The effects inducing or inhibiting strongly depend studied type. search for new therapeutic targets, chondrocytes might promising any type On other hand, induction may also lead to desired decrease synovial fibroblasts RA. Thus, must consider cell-type-specific Further investigation needed clarify these complexities.

Language: Английский

Citations

3
Decoding ferroptosis: transforming orthopedic disease management DOI Creative Commons

Guochen Huo,

Yumeng Lin,

Lusheng Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, other death mechanisms. It implicated the advancement multiple diseases across body. Researchers currently know that osteosarcoma, osteoporosis, orthopedic disorders are caused NRF2, GPX4, star proteins. effective relief osteoarthritis symptoms from deterioration been confirmed clinical treatment with inhibitors. At same time, it should be reminded mechanisms involved regulate not understood. In this manuscript, we present discovery ferroptosis, role variety diseases. We expect manuscript can provide new perspective on diagnosis related

Language: Английский

Citations

1
Siweixizangmaoru Decoction Ameliorated Type II Collagen-Induced Arthritis in Rats <i>via</i> Regulating JAK2–STAT3 and NF-κB Signaling Pathway DOI Open Access

Yanfei Niu,

Qianjing Feng,

Mingxue Cui

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 47(9), P. 1511 - 1524

Published: Sept. 12, 2024

Siweixizangmaoru decoction (SXD) is widely used as an anti-rheumatoid arthritis (RA) in Tibet, however, the specific anti-inflammatory mechanism of SXD still unclear. This research attempts to examine efficacy and possible mechanisms treating RA. The primary chemical components were identified using UHPLC-Q-Exactive Orbitrap MS. We established a lipopolysaccharide (LPS)-induced RAW264.7 macrophage inflammatory injury model explore validated it through vivo experiments. According our vitro well vivo, exhibits qualities. can suppress nitric oxide (NO) pro-inflammatory factor production cells activated by LPS. underlying this effect might be connected janus tyrosine kinase 2-signal transducer activator transcription 3 (JAK2/STAT3) nuclear factor-κB (NF-κB) signaling pathways. In alleviates joint swelling, decreases generation factors serum, lowers oxidative stress, improves damage. short, degeneration symptoms associated with RA regulating inflammation via suppression NF-κB JAK2/STAT3 pathway activation.

Language: Английский

Citations

0