Study on the Protective Effect and Mechanism of Umbilicaria esculenta Polysaccharide in DSS-Induced Mice Colitis and Secondary Liver Injury

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(19), P. 10923 - 10935

Published: May 1, 2024

This study aimed to explore the ameliorative effects and potential mechanisms of Huangshan Umbilicaria esculenta polysaccharide (UEP) in dextran sulfate sodium-induced acute ulcerative colitis (UC) UC secondary liver injury (SLI). Results showed that UEP could ameliorate both colon pathologic injuries, upregulate mouse intestinal tight junction proteins (TJs) MUC2 expression, reduce LPS exposure, thereby attenuating gut–liver axis. Importantly, significantly downregulated secretion levels TNF-α, IL-1β, IL-6 through inhibition NF-κB pathway activated Nrf2 signaling increase expression SOD GSH-Px. In vitro, inhibited LPS-induced phosphorylation P65 promoted nuclear translocation RAW264.7 cells. These results revealed ameliorated SLI Nrf2-mediated inflammation oxidative stress. The first investigated anticolitis effect UEP, suggesting its for treatment colitis-associated disease.

Language: Английский

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Wheat peptide alleviates DSS-induced colitis by activating the Keap1–Nrf2 signaling pathway and maintaining the integrity of the gut barrier

Food & Function, Journal Year: 2024, Volume and Issue: 15(10), P. 5466 - 5484

Published: Jan. 1, 2024

Inflammatory bowel disease (IBD) is difficult to cure, and formulating a dietary plan an effective means prevent treat this disease.

Language: Английский

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Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 112024 - 112024

Published: April 11, 2024

Language: Английский

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p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155941 - 155941

Published: Aug. 6, 2024

Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease (IBD), presents with limited current drug treatment options. Consequently, the search for safe and effective UC prevention is imperative. Our prior studies have demonstrated that phenolic compound p-Hydroxybenzaldehyde (HD) from Nostoc commune, effectively mitigates intestinal inflammation. However, mechanisms underlying HD's anti-inflammatory effects remain unclear.

Language: Английский

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Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139929 - 139929

Published: Jan. 1, 2025

Language: Английский

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Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157484 - 157484

Published: Nov. 1, 2024

Language: Английский

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Effect of Food Matrix on Regulation of Intestinal Barrier and Microbiota Homeostasis by Polysaccharides Sulfated Carrageenan

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 635 - 635

Published: Feb. 14, 2025

Carrageenan (CGN) has side effects on the intestinal barrier. Damage to barrier is associated with exposure sulfate groups. Food matrix significant influence quantity of groups and conformation in κ-CGN, but corresponding are not reported specifically. This study aimed explore regulatory effect κ-CGN dissolved aqueous (κ-CGN) 3% casein (κ-carrageenan-casein, κ-CC) microbiota homeostasis. Research shown that both κ-CC can induce different extents damage through disrupting Importantly, lower content was found repair injury induced by an equivalent dose increasing abundance Oscillibacter decreasing Weissella. These alleviating were reflected levels tumor necrosis factor (TNF)-α C-reaction protein (CRP), higher interleukin (IL)-10, raised secretion mucus goblet cells, improved expression epithelial cell compact proteins zonula occluden (ZO)-1 mucin 2 (MUC2). states a positive compared solution, which provide guidance for processing utilization CGN.

Language: Английский

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Arginine-terminated egg white peptide Leu-Phe-Arg (LFR) repairs intestinal barrier damage through the PI3K/AKT/mTOR/p70s6k signaling pathway: An analysis combined transcriptomics and proteomics

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106502 - 106502

Published: April 1, 2025

Language: Английский

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Structure and regulatory mechanisms of food‐derived peptides in inflammatory bowel disease: A review

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(9), P. 6055 - 6069

Published: June 18, 2024

Abstract The number of patients with inflammatory bowel disease (IBD) is increasing worldwide. Since IBD a chronic that seriously affects patients' life quality, preventing and alleviating natural less side effect substances has become research hotspot. Food‐derived bioactive peptides have been an attractive focus due to their high efficiency low toxicity. This paper comprehensively summarizes food‐derived intestinal health effects, focusing on peptide sequences IBD‐regulatory effects emphasizing the structure physicochemical properties such as length, amino acid composition, net charge function. We also analyzed its regulatory mechanisms, mainly in 5 aspects: modulating microbiota, decreasing epithelial permeability, antioxidant ability, regulating expression cytokines, targeting signaling pathways. review will help establish novel, efficient screening methods for contribute further discovery them.

Language: Английский

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Pharmacological modulation of mitochondrial function as novel strategies for treating intestinal inflammatory diseases and colorectal cancer

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101074 - 101074

Published: Aug. 1, 2024

Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal disease, has become major global health issue. Individuals with IBD face an elevated risk of developing colorectal cancer (CRC), recent studies have indicated that mitochondrial dysfunction plays pivotal role in the pathogenesis both CRC. This review covers CRC, focusing on dysfunction, explores pharmacological targets strategies for addressing conditions by modulating function. Additionally, advancements modulation treating encompassing damage, release DNA (mtDNA), impairment mitophagy, are thoroughly summarized. The also provides systematic overview natural compounds (such as flavonoids, alkaloids, diterpenoids), Chinese medicines, microbiota, which can alleviate attenuate progression CRC In future, it will be imperative to develop more practical methodologies real-time monitoring accurate detection function, greatly aid scientists identifying effective agents through

Language: Английский

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