Regional and longitudinal dynamics of human milk protein components assessed by proteome analysis on a fast and robust micro-flow LC–MS/MS system DOI

Junxia Cao,

Xinling Cui, Haiyan Lu

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 465, P. 141981 - 141981

Published: Nov. 9, 2024

Language: Английский

Revealing the diversity of endogenous peptides and parent proteins in human colostrum and mature milk through peptidomics analysis DOI
Jianting Ning, Mei Yang,

Qing Zhu

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 445, P. 138651 - 138651

Published: Feb. 5, 2024

Language: Английский

Citations

5

A review of genetic resources and trends of omics applications in donkey research: focus on China DOI Creative Commons
Muhammad Zahoor Khan, Wenting Chen, Xinrui Wang

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 11, 2024

Omics methodologies, such as genomics, transcriptomics, proteomics, metabolomics, lipidomics and microbiomics, have revolutionized biological research by allowing comprehensive molecular analysis in livestock animals. However, despite being widely used various animal species, on donkeys has been notably scarce. China, renowned for its rich history donkey husbandry, plays a pivotal role their conservation utilization. China boasts 24 distinct breeds, necessitating efforts, especially smaller breeds facing extinction threats. So far, omics approaches employed studies of milk meat, shedding light composition quality. Similarly, methods utilized to explore the basis associated with growth, meat production, quality traits. also unraveled critical microbiota health nutrition, gut microbiome revealing associations factors pregnancy, age, transportation stress, altitude. Furthermore, applications addressed issues, including infectious diseases reproductive problems. In addition, these provided insights into improvement efficiency research. conclusion, methodologies are essential advancing knowledge about donkeys, genetic diversity, across domains. is still infancy, there need continued enhance breeding, welfare beyond.

Language: Английский

Citations

4

Peptidomic Differences Between Natural Musk and Secretions from Forest Musk Gland Cells Cultured In Vitro DOI Creative Commons
Zhiying Huang, Guijun Zhao,

Dejun Zeng

et al.

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Background The Chinese forest musk deer, a solitary ungulate renowned for its secretion, is under extinction threat despite extensive use in traditional medicine and perfumery. demand significantly outstrips natural supply. Purpose This study aimed to explore the differences peptide profiles between cultured gland cells develop sustainable alternatives production aid conservation of deer. Materials Methods Musk samples from deer were collected analyzed using EASY-nLC 1000 system. Peptide extraction, nano LC–MS/MS analysis, advanced peptidomics techniques employed identify compare compositions. Results found significant secreted Cultured could partially replicate complex environment musk, with some unique peptides identified not present secretions. Conclusion While show potential mimicking synthesis, notable suggest importance gland’s microenvironment deer’s physiological conditions. research establishes foundation optimizing culture enhance therapeutic qualities synthesized contributing species.

Language: Английский

Citations

0

Whey protein and endogenous oligopeptide profiles: A comparative study of human and major domestic animal milk DOI
Mengru Zhang, Zeyuan Deng,

Hailing Song

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106309 - 106309

Published: March 1, 2025

Language: Английский

Citations

0

The Milk Compositions and Blood Parameters of Lactating Dezhou Donkeys Changes With Lactation Stages DOI Creative Commons
Miaomiao Zhou,

Zongjie Ma,

Xinyi Du

et al.

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(2)

Published: March 1, 2025

The aim of this study was to investigate the changes in milk compositions and blood parameters Dezhou donkeys during lactation. Milk serum samples from six lactating were collected at 1, 30, 60, 90, 120, 150 180 days results displayed that yield lactation first increased then gradually decreased, with peak production period 30-60 after parturition. Compared other stages, fat, protein, solids non-fat (SNF) higher early (p < 0.05). Conversely, late stage had a lactose content 0.05); mineral elements donkey decreased prolongation prolactin (PRL), insulin-like growth factor 1 (IGF-1), total protein (TP), albumin (ALB), glucose (GLU), cholesterol (TG), triglyceride (TC), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), high density lipoprotein (HDL) low (LDL) 0.05), similar correlation analysis showed positively correlated PRL, IGF-1 ALP, negatively ALB composition, such as SNF GLU, LDH, TP, ALB, TC, TG, HDL LDL above indicated significant effects on production, biochemical indicators hormone donkeys. This investigated donkeys' performance stages for time, which may contribute exploration nutritional value provide theoretical support regulation utilisation milk.

Language: Английский

Citations

0

A Comprehensive Review of Milk Components: Recent Developments on Extraction and Analysis Methods DOI Creative Commons
Maria Assunta Acquavia,

A. Villone,

Rosa Rubino

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1994 - 1994

Published: April 30, 2025

In recent years, there has been a growing interest in identifying both the macro- and micro-constituents of milk, as their functional health benefits have recognized. This review provides comprehensive overview all milk constituents, including fats, proteins, oligosaccharides polysaccharides, vitamins, minerals polyphenols, along with extraction protocols analytical methods employed for separation detection over last ten years. The principles, strengths limitations these are discussed, highlighting importance advancing research. Traditional such spectrophotometry, advanced technologies, like mass spectrometry omics approaches, described to collectively enable understanding milk’s nutritional components. Election criteria platforms suitable target analytes provided.

Language: Английский

Citations

0

Science and Faith to Understand Milk Bioactivity for Infants DOI Open Access
Per Torp Sangild

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1676 - 1676

Published: May 29, 2024

Milk bioactivity refers to the specific health effects of milk components beyond nutrition. The science involves systematic study these and their effects, as verified by empirical data, controlled experiments, logical arguments. Conversely, ’faith in bioactivity’ can be defined personal opinion, meaning, value, trust, hope for that are investigation natural, social, or human sciences. Faith strictly secular, but also influenced spirituality religion. aim this paper is show scientific knowledge frequently supplemented with faith convictions establish public understanding bioactivity. Mammalian an immensely complex fluid containing myriad proteins, carbohydrates, lipids, micronutrients multiple functions across species, genetics, ages, environments, cultures. Human includes not only physical health, mental, spiritual requiring widely different fields prove relevance, safety, efficacy interventions. These relationships between feeding outcomes prevent firm conclusions based on logic alone. Current beliefs value breast milk, colostrum, infant formula, isolated proteins (e.g., immunoglobulins, α-lactalbumin, lactoferrin, growth factors) both contribute understand, stimulate, restrict use benefits breastfeeding infants doubt, strong its rely science, mechanisms unclear. Likewise, fear of, trust in, formula may faith. Knowledge from safeguards individuals society against ‘milk superstition’. wisdom faith-based protect unrealistic scientism’. Honesty transparency about potentials limitations important when informing nutritious bioactive qualities milk.

Language: Английский

Citations

3

Glutamine‐derived peptides: Current progress and future directions DOI
Tianfei Yu,

T. Hu,

Kai Na

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(4)

Published: June 7, 2024

Abstract Glutamine, the most abundant amino acid in body, plays a critical role preserving immune function, nitrogen balance, intestinal integrity, and resistance to infection. However, its limited solubility instability present challenges for use functional nutrient. Consequently, there is preference utilizing glutamine‐derived peptides as an alternative achieve enhanced functionality. This article aims review applications of glutamine monomers clinical, sports, enteral nutrition. It compares effectiveness provides comprehensive assessment terms their classification, preparation, mechanism absorption, biological activity. Furthermore, this study explores potential integration artificial intelligence (AI)‐based peptidomics synthetic biology de novo design large‐scale production these peptides. The findings reveal that possess significant structure‐related bioactivities, with smaller molecular weight fraction serving primary active ingredient. These ability promote homeostasis, exert hypotensive hypoglycemic effects, display antioxidant properties. our understanding structure–function relationships remains largely exploratory at current stage. combination AI based presents opportunity explore untapped resources food ingredients. Additionally, utilization bioavailability can be through delivery systems vivo. serves valuable reference future investigations developments discovery, validation, biomanufacturing science.

Language: Английский

Citations

3

Is there sufficient evidence to support the health benefits of including donkey milk in the diet? DOI Creative Commons
Muhammad Zahoor Khan, Wenting Chen, Mengmeng Li

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Donkey milk has attracted attention due to its distinctive nutritional composition and potential health advantages, particularly because of whey protein content, which includes lysozyme,

Language: Английский

Citations

3

Bovine Milk Fat Globule Membrane Supplementation and Neurocognitive Development: A Systematic Review and Meta-Analysis DOI Open Access
Therdpong Thongseiratch, Kulnipa Kittisakmontri,

Nutthaporn Chandeying

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2374 - 2374

Published: July 22, 2024

Given the limited evidence, there is no conclusive proof of neurocognitive benefits bovine milk fat globule membrane supplementation in infant formula. This study evaluates formula, comparing it to standard formula and assessing its noninferiority breast milk. Data were sourced from studies published between January 2000 March 2024 PubMed, Cochrane Library, Web Science, Embase. Eight randomized controlled trials involving 1352 healthy term neonates, infants, children up 2 years old included. Bovine was significantly associated with improved cognitive development (mean difference: 3.29, 95% CI: 1.65 4.93, p < 0.001) demonstrated minimal heterogeneity (I2 = 0%, 0.564). It showed significant improvement executive function but not language, motor, or social-emotional development. In non-inferiority analysis, difference compared regarding These findings support as a valuable addition for benefits.

Language: Английский

Citations

2