Design, synthesis and antiviral activity of coumarin derivatives containing 1,3,4- oxadiazole/thidiazole DOI Creative Commons

Yuzhi Hu,

Zhiling Sun, Wei Zeng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract In this paper, a series of oxadiazole/thidiazole containing coumarin derivative derivatives were designed, synthesized and characterized using NMR HRMS. The evaluation antiviral activity revealed that some the compounds exhibited good in vivo efficacy against tobacco mosaic virus (TMV). Notably, H6 Y5 demonstrated exceptional therapeutic protective effects TMV, with EC50 values 180.7, 190.3 215.8, 218.6 µg/mL, respectively, surpassing NingNanmycin, which 284.1 247.1 µg/mL. preliminary mechanistic studies indicated had ahigh binding affinity for capsid protein (TMV-CP), potentially obstructing self-assembly replication processes TMV particles. Furthermore, chlorophyll content superoxide dismutase (SOD) in leaves increased, while malondialdehyde (MDA) decreased. has potential to be developed as novel antiviral.

Language: Английский

Coumarin derivatives containing the 1,3,4 oxadiazole/thiadiazole moiety discovered as potential anti-tobacco mosaic virus agents DOI Creative Commons

Yuzhi Hu,

Zhiling Sun, Wei Zeng

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents DOI
Betül Kaya, Ulviye Acar Çevik, Pervin Soyer

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract This study assessed the in vitro antibacterial and antibiofilm properties of new 1,3,4-thiadiazole derivatives. 1 H NMR 13 C analyses were employed to confirm structure synthesized compounds, characterization is followed by assessments their efficacy against Bacillus subtilis NRRL B478, Staphylococcus aureus ATCC 29213, Escherichia coli 25922, Pseudomonas aeruginosa 27853, as well for antifungal activity Candida albicans 90028 krusei 6258, using broth microdilution method. Notably, among tested compound 4a exhibited highest antimicrobial activity, with a minimal inhibitory concentration 125 μg/mL P. 27853 significant achieving 94 %, 98 % 100 biofilm inhibition at 250, 500 1,000 μg/mL, respectively. Besides, 4h achieved 81 89 S. 29213 respectively, displayed potent this bacterium. Finally, theoretical ADME compounds - analyzed calculations. has consolidated base development agents advanced our understanding potential mode action biofilm-associated infections.

Language: Английский

Citations

0
Ionic Liquid-Assisted Approaches in the Synthesis of Nitrogen-Containing Heterocycles: A Focus on 3- to 6-Membered Rings DOI Creative Commons

P. K. Maity,

Amrit Krishna Mitra

Journal of Ionic Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 100146 - 100146

Published: March 1, 2025

Language: Английский

Citations

0
Thiol-Epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing a 1,2,4-Triazole Ring DOI Creative Commons
Artyom V. Petrosyan, Astghik A. Shahkhatuni, Andranik M. Davinyan

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(2), P. 53 - 53

Published: April 1, 2025

As examples of “Click Chemistry”, the reaction 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. a result, shows that oxirane ring opens regiospecifically, according to Krasusky’s rule, without using catalyst. The basic nitrogen present in has catalytic (anchimer) effect.

Language: Английский

Citations

0
Decanal: A Direct Defense Volatile Induced by Colletotrichum fructicola in the Tea Cultivar “Qiancha No. 1” DOI

Yongjia Cheng,

Yao Chen, Jianjun Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Plants release a variety of defensive volatiles in response to biotic stress. The present study examined interactions between Colletotrichum fructicola and the defense induced by this fungal species tea cultivar "Qiancha No. 1". Analysis emitted from C. fructicola-infected leaves 1" revealed that four showed relative content increase more than 2%. Fungicidal activity assays demonstrated decanal exhibited strongest antifungal among volatiles. Further physiological experiments mechanism was associated with disruption cell wall membrane. Transcriptome analysis genes encoding Chitinase 1, chitin synthase endochitinase42 were identified as potential targets may be involved degradation decanal. Additionally, cytochrome P450-DIT2 multidrug resistance protein fer6 membrane damage. This is first demonstrate acts direct volatile interaction 1," highlighting its an effective agent.

Language: Английский

Citations

0
Structural activity of synthesized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as anticancer agents DOI Creative Commons

Abeer Mogadem,

Abrar Bayazeed,

Abdulmajeed F. Alrefaei

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 101813 - 101813

Published: Sept. 23, 2024

Language: Английский

Citations

2
Design, Synthesis, and Biological Activity Studies of Myricetin Derivatives Containing a Diisopropanolamine Structure DOI

Youshan An,

Hongqian Zou,

Qing Zhou

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(45), P. 25034 - 25044

Published: Nov. 5, 2024

A series of myricetin derivatives containing diisopropanolamine were designed and synthesized. The in vitro inhibitory effects the target compounds on 9 fungal pathogens 3 bacterial also evaluated. A12 had best effect against Xanthomonas oryzae pv. (Xoo), with an EC50 value 4.9 μg/mL, which was better than zinc–thiazole (ZT: = 7.3 μg/mL) thiodiazole–copper (TC: 65.5 μg/mL); A25 Phomopsis sp. (Ps), 17.2 azoxystrobin (Az: 22.3 μg/mL). In vivo inhibition tests performed kiwifruit for rice leaves A12. At 200 curative activity leaf blight 40.7%, that ZT (37.2%) TC (32.9%), protective 44.8%, (39.5%) (34.6%). kiwi soft rot disease 70.1%, Az (62.8%). Preliminary elucidation possible mechanisms action carried out by experiments fluorescence microscopy, scanning electron formation biofilms, density functional theory calculations, so on.

Language: Английский

Citations

1
Synthesis and Antifungal Activity Evaluation of Novel L-Carvone-Based 1,3,4-Thiadiazole-amide Derivatives as a Potential Succinate Dehydrogenase Inhibitor DOI
Baoyu Li, Wengui Duan,

Guishan Lin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(47), P. 26116 - 26124

Published: Nov. 14, 2024

In an effort to explore new-type high-efficiency antifungal agents, 25 novel

Language: Английский

Citations

1
New chalcone derivatives containing morpholine-thiadiazole: Design, synthesis and evaluation of against tobacco mosaic virus DOI
Wei Zeng, Zhiling Sun, Yufang Zhang

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 179, P. 106272 - 106272

Published: Oct. 22, 2024

Language: Английский

Citations

0
Antifungal activity of chalcone derivatives containing 1,2,3,4‐tetrahydroquinoline and studies on them as potential SDH inhibitors DOI Open Access

Tianyu Deng,

Hui Xin,

Xingping Luo

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

A large number of pathogenic fungi have caused serious damage to the global crop yield, and drug resistance is always a topic that cannot be avoided for traditional fungicides. Therefore, finding efficient, green, low-toxic fungicides our primary task, which brings opportunities development natural product green pesticides.

Language: Английский

Citations

0