Review on bioproduction of sialylated human milk oligosaccharides: Synthesis methods, physiologic functions, and applications DOI
Chenchen Li, Zhu Liu, Mengli Li

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123177 - 123177

Published: Dec. 25, 2024

Language: Английский

Synthesising human milk oligosaccharide using biotechnology-driven enzymes DOI

Jayashree Niharika,

Ravindra Pal Singh

Systems Microbiology and Biomanufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
Highly efficient biosynthesis of 3′-sialyllactose in engineered Escherichia coli DOI
Wenbo Zhang, Yingying Zhu, Hao Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132081 - 132081

Published: May 3, 2024

Language: Английский

Citations

6
Multi-level metabolic engineering of 6ʹ-sialyllactose in Escherichia coli DOI
Chenchen Li, Mengli Li,

Mo Han

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106078 - 106078

Published: Feb. 1, 2025

Language: Английский

Citations

0
Improving 3′-sialyllactose biosynthesis in Escherichia coli by engineering Neisseria meningitidis 406Y α2,3-sialyltransferase DOI

Qian Lin,

Yuanlin Liu, Hao Wang

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Comprehensive review on human Milk oligosaccharides: Biosynthesis, structure, intestinal health benefits, immune regulation, neuromodulation mechanisms, and applications DOI

Jieting Yu,

Le Li, Supaluck Kraithong

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116328 - 116328

Published: April 6, 2025

Language: Английский

Citations

0
Biosynthesis of Sialyllacto-N-tetraose c in Engineered Escherichia coli DOI
Chenchen Li, Mengli Li, Wei Gao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(46), P. 25836 - 25846

Published: Nov. 7, 2024

Human milk oligosaccharides (HMOs) have attracted considerable interest for their vital role in supporting infant health. Among these, sialyllacto-

Language: Английский

Citations

2
Human milk oligosaccharides produced by synthetic biology DOI Creative Commons

Jessica Bensimon,

Xiaonan Lu

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 18, P. 101361 - 101361

Published: Aug. 15, 2024

The benefits of human breast milk (HBM) to newborn growth, development, and overall health have been well investigated. As breastfeeding rate has declined significantly, the use infant formula risen remains a significant component infant's diet. HBM contains several essential nutritional components, with oligosaccharides (HMO) being third most abundant following lactose lipids. A diverse array HMOs is known exert great in intestinal, immune, cognitive functions. In contrast HBM, containing mainly bovine lacks diversity HMOs. Efforts made replicate this characteristic through chemical chemoenzymatic synthesis as microbial production. Utilizing hosts appears be more favourable due its accessibility cost-efficiency. Escherichia coli preferably used high incorporation DNA, high-level expression capability, rapid growth. However, potential endotoxin contamination raises concerns prevents approval Generally Recognized Safe (GRAS) by FDA. This prompts other microbes such Bacillus subtilis. Future research area needed optimize effective procedures using hosts, yield production, economic feasibility. may lead formulas closely mimicking benefits.

Language: Английский

Citations

1
Review on bioproduction of sialylated human milk oligosaccharides: Synthesis methods, physiologic functions, and applications DOI
Chenchen Li, Zhu Liu, Mengli Li

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123177 - 123177

Published: Dec. 25, 2024

Language: Английский

Citations

1