Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 33(9), P. 2221 - 2243

Published: July 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Language: Английский

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Antioxidant mechanism of tea polyphenols and its impact on health benefits

Animal nutrition, Journal Year: 2020, Volume and Issue: 6(2), P. 115 - 123

Published: Jan. 23, 2020

Tea trees have a long history of cultivation and utilization. People in many countries the habit drinking tea choosing green tea, oolong or black according to different regions personal tastes. polyphenols are general term for polyphenol compounds has been shown good effects on antioxidant, anti-inflammatory, cancer prevention regulation lipid metabolism. widely used as antioxidants disease treatment animal husbandry, but their specific mechanism action needs be further clarified revealed. This review focuses definition, classification, antioxidant activity signaling pathways polyphenols. paper also aims examine application human health, providing scientific basis this addition proposing future directions development resource.

Language: Английский

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Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Sept. 7, 2021

Abstract Background Alteration of the gut microbiota may contribute to development inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent green tea, is known be beneficial in IBD alleviation. However, it unclear whether exerts an effect when EGCG attenuates IBD. Results We first explored oral or rectal delivery on DSS-induced murine colitis. Our results revealed that anti-inflammatory and colonic barrier integrity were enhanced by oral, but not rectal, EGCG. observed distinct EGCG-mediated alteration microbiome increasing Akkermansia abundance butyrate production. Next, we demonstrated pre-supplementation induced similar outcomes administration. Prophylactic attenuated colitis significantly enriched short-chain fatty acids (SCFAs)-producing bacteria such as SCFAs production mice. To validate these discoveries, performed fecal transplantation (FMT) sterile filtrate (SFF) inoculate DSS-treated Microbiota from EGCG-dosed mice alleviated over control SFF shown superiorly integrity, also SCFAs. Collectively, attenuation suggests intimate involvement SCFAs-producing , SCFAs, which was further prophylaxis FMT. Conclusions This study provides data indicating ameliorated inflammation microbiota-dependent manner. findings provide novel insights into remission potential modulator for prevent treat

Language: Английский

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Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

Food Research International, Journal Year: 2021, Volume and Issue: 142, P. 110189 - 110189

Published: Jan. 29, 2021

Language: Английский

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Bioactive Phenolic Compounds From Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: May 7, 2020

Phenolic compounds are broadly represented in plant kingdom, and their occurrence easily accessible low-cost sources like wastes from agri-food processing have led the last decade to an increase of interest recovery further exploitation. Indeed, most these endowed with beneficial properties human health (e.g. prevention cancer cardiovascular diseases), that may be largely ascribed potent antioxidant scavenging activity against reactive oxygen species generated settings oxidative stress responsible for onset several inflammatory degenerative diseases. Apart use as food supplements or additives functional foods, natural phenolic become increasingly attractive also a technological point view, due possible exploitation materials science. Several extraction methodologies been reported mostly based on organic solvents such methanol, ethanol, acetone. However, there is increasing need green sustainable approaches leading phenolic-rich extracts low environmental impact. This review addresses promising innovative waste appeared recent literature. In particular, procedures technologies (supercritical fluid, microwaves, ultrasounds) well deep eutectic (DES) surveyed

Language: Английский

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Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 146, P. 112442 - 112442

Published: Jan. 4, 2022

Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence progression. Antioxidants have attracted attention as emerging therapeutic agents. Among these are flavonoids, which natural polyphenols with established anticancer antioxidant capacities. Increasing evidence shows that flavonoids can inhibit carcinogenesis via suppressing ROS levels. Surprisingly, also trigger excessive oxidative stress, but this induce death malignant cells. In review, we explore inherent characteristics contribute to capacity dissect scenarios they contrasting role pro-oxidants. Furthermore, elaborate on pathways link flavonoid-mediated modulation prevention treatment cancer. Special given ROS-mediated functions (-)-epigallocatechin gallate (EGCG), hesperetin, naringenin, quercetin, luteolin, apigenin evoke various cancers. We delve into structure-function relations make potent antioxidants. This review provides detailed perspective be utilized future experiments or trials aim at utilizing verifying their efficacy for developing new pharmacologic support argument attractive candidates therapy.

Language: Английский

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Tea and tea drinking: China’s outstanding contributions to the mankind

Chinese Medicine, Journal Year: 2022, Volume and Issue: 17(1)

Published: Feb. 22, 2022

Tea trees originated in southwest China 60 million or 70 years ago. Written records show that Chinese ancestors had begun drinking tea over 3000 Nowadays, with the aging of populations worldwide and more people suffering from non-communicable diseases poor health, beverages have become an inexpensive fine complementary alternative medicine (CAM) therapy. At present, there are 3 billion who like to drink world, but few them actually understand tea, especially on its development process spiritual cultural connotations.We searched PubMed, Google Scholar, Web Science, CNKI, other relevant platforms key word "tea", reviewed analyzed tea-related literatures pictures past 40 about tea's history, culture, customs, experimental studies, markets.China is hometown trees, drinking, culture. has oldest wild planted fossil a leaf 35,400,000 ago, abundant art works. Moreover, may be first herbal (CHM) used by ancient times. many benefits our physical health via antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity activities. moment, COVID-19 wreaking havoc across globe causing severe damages people's lives. anti-COVID-19 functions enhancement innate immune response inhibition viral growth. Besides, can allow acquire peaceful, relaxed, refreshed cheerful enjoyment, even longevity. According meridian theory traditional medicine, different kinds activate systems human body. black (fermented tea) green (non-fermented most popular world. Black accounts for 90% all teas sold western countries. The world's top-grade include Qi Men China, Darjeeling Assam India, Uva Sri Lanka. However, top ten famous world produced Xi Hu Long Jing among teas. More than 700 components 27 mineral elements found tea. polyphenols theaflavin/thearubigins considered major bioactive respectively. Overly strong overheated liquid should avoided when tea.Today, CAM provides array treatment modalities promotion both developed developing countries simple herb-based therapy, man-made non-alcoholic beverage widely consumed worldwide, it improve growth economy as well. mental promote harmonious society through chemical elements.

Language: Английский

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Natural polyphenols in drug delivery systems: Current status and future challenges

Giant, Journal Year: 2020, Volume and Issue: 3, P. 100022 - 100022

Published: Aug. 1, 2020

Natural polyphenols have attracted great interests in medicine, food and cosmetics due to their versatile functions such as antioxidant, anticancer antibacterial. The polyphenolic structures (i.e. catechol, pyrogallol) natural are responsible for strong noncovalent interactions via multiple hydrogen bonding hydrophobic interactions, dynamic covalent complexation with boronate groups metal ions. In this review, we focused on the preparation applications of polyphenol-based coating films, nanoparticles, nanocapsules, hydrogels emerged from chemical functional signatures. beneficial role mechanism facilitating delivery proteins, nucleic acids conventional drug molecules were reviewed. Finally, challenges systems perspectives rational design next generation polyphenol biomaterials will be discussed.

Language: Английский

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A review on insoluble-bound phenolics in plant-based food matrix and their contribution to human health with future perspectives

Trends in Food Science & Technology, Journal Year: 2020, Volume and Issue: 105, P. 347 - 362

Published: Sept. 28, 2020

Language: Английский

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Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Molecules, Journal Year: 2020, Volume and Issue: 25(20), P. 4613 - 4613

Published: Oct. 10, 2020

Polyphenols are micronutrients that widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, for cancer prevention, heart protection the treatment of neurodegenerative diseases. However, due to vulnerability environmental conditions low bioavailability, application food medical fields is greatly limited. Nanoformulations, excellent drug delivery systems, can overcome these limitations maximize pharmacological effects polyphenols. In this review, we summarize biological activities polyphenols, together with systems delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based niosomes, polymers, micelles, emulsions metal nanoparticles. The polyphenol nanoparticles medicine also discussed. Although loading into solves main limitation polyphenolic compounds, there some concerns about toxicological safety after entry body. It therefore necessary conduct toxicity residue analysis on carrier.

Language: Английский

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