Semi-rational engineering of a novel halohydrin dehalogenase from Sneathiella limimaris for the enantioselective synthesis of (S)-5-phenoxymethyl-2-oxazolidinone DOI

Ji Ding,

Jinsong Song,

Shan Huang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108292 - 108292

Published: Feb. 19, 2025

Language: Английский

Biocatalytic Efficient and Enantiocomplementary Synthesis of 3-Hydroxy-3-hydroxymethyloxindoles by Combining Halohydrin Dehalogenase and Epoxide Hydrolase DOI

Run‐Ping Miao,

Haixia Zhang, Ke Lü

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 992 - 1001

Published: Jan. 2, 2025

Language: Английский

Citations

0
Biocatalytic enantioselective formation and ring-opening of oxetanes DOI Creative Commons
Xia Hua, Yuanfei Wang, Xiao Jin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 30, 2025

Although biocatalysis offers complementary or alternative approaches to traditional synthetic methods, the limited range of available enzymatic reactions currently poses challenges in synthesizing a diverse array desired compounds. Consequently, there is significant demand for developing novel biocatalytic processes enable that were previously unattainable. Herein, we report discovery and subsequent protein engineering unique halohydrin dehalogenase develop platform enantioselective formation ring-opening oxetanes. This platform, exhibiting high efficiency, excellent enantioselectivity, broad scopes, facilitates preparative-scale synthesis chiral oxetanes variety γ-substituted alcohols. Additionally, both oxetane are proven scalable large-scale transformations at substrate concentrations, can be integrated efficiently one-pot, one-catalyst cascade system. work expands toolbox non-natural will promote further exploration catalytic repertoire dehalogenases pharmaceutical chemistry. Oxetane four-membered, oxygen-containing heterocyclic compound importance medicinal chemistry drug development. Here, authors dehalogenase,

Language: Английский

Citations

0
Characterization of the phenotype and functional alternations of three HCN1 variants in Chinese epilepsy patients DOI
Ziyao Han, Lingling Xie, Xiaorui Liu

et al.

Epilepsy Research, Journal Year: 2025, Volume and Issue: 211, P. 107521 - 107521

Published: Feb. 7, 2025

Language: Английский

Citations

0
Semi-rational engineering of a novel halohydrin dehalogenase from Sneathiella limimaris for the enantioselective synthesis of (S)-5-phenoxymethyl-2-oxazolidinone DOI

Ji Ding,

Jinsong Song,

Shan Huang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108292 - 108292

Published: Feb. 19, 2025

Language: Английский

Citations

0