Future Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: Dec. 22, 2024
Organoselenium
chemistry
has
become
a
significant
field
due
to
its
role
in
synthesizing
numerous
biologically
active
and
therapeutic
compounds.
In
early
phase,
researchers
focused
on
designing
organoselenium
compounds
with
antioxidant
properties
were
quite
successful.
last
two
decades,
synthetic
chemists
shifted
their
focus
toward
synthesis
of
biological
properties,
moving
beyond
traditional
properties.
The
review
includes
study
organo-selenium
as
anticancer,
antimicrobial,
antiviral,
antidiabetic,
antithyroid,
anti-inflammatory
therapies,
contributing
disease
treatment.
This
covers
the
medicinal
applications
over
past
10
years,
thus
making
it
valuable
resource
for
chemistry.
Medical Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Abstract
Selenium
(Se)
is
an
essential
trace
mineral
crucial
for
human
health.
Nearly
a
dozen
clinical
trials
with
seleno-methionine
(SeMet)
and
selenized-yeast
(contains
mostly
SeMet)
the
prevention
of
non-cutaneous
solid
organ
cancers
in
North
America
European
countries
conclusively
refuted
their
utility.
We
have
articulated
two
lessons
from
these
trials:
(1)
anti-oxidant
hypothesis
was
tested
inappropriate
Se-adequate
populations,
(2)
selection
Se
forms
not
supported
by
cell
culture
animal
efficacy
data.
Nevertheless,
preclinical
studies
proximal
methylselenol
precursors
(“methyl
Se”)
shown
many
desirable
attributes,
involving
molecules
pathways
cancer
epithelial
cells,
vascular
endothelial,
immune
inflammatory
cells
tumor
microenvironment,
potential
use
as
chemopreventive
therapy
agents.
Methylseleninic
acid
Se-methylselenocysteine
are
prototypical
methyl-Se,
yet
equal
targets.
Selenate,
selenite
selenious
had
been
recently
studied
trials,
providing
novel
safety
data,
but,
missing
critical
genotoxicity
assessments.
Given
popularity
Se-enriched
foods
China
continued
presence
nutritional
deficiency
localities,
we
discuss
recommendations
or
chemoprevention
other
similar
nutrition
predicament.
JACS Au,
Journal Year:
2025,
Volume and Issue:
5(2), P. 578 - 585
Published: Jan. 21, 2025
A
general
method
for
the
catalytic
asymmetric
α-selenenylation
of
simple
carbonyl
compounds
is
lacking.
Herein,
a
copper(I)-catalyzed
enantioselective
2-acylimidazoles
with
electrophilic
selenosulfonates
uncovered.
The
reaction
enjoys
advantages
mild
conditions,
easy
protocol,
and
broad
substrate
scopes
on
both
selenosulfonates.
Mechanistic
studies
reveal
pincer
Cu(I)-(S,S)-Ph-BOPA
complex
as
active
catalyst.
Some
traditional
selenenylation
reagents,
such
PhSeCl,
PhSeSePh,
2-(phenylselanyl)isoindoline-1,3-dione
lead
to
inferior
results
in
terms
yield
enantioselectivity,
highlighting
superiority
Finally,
several
transformations
based
2-acylimidazole
group
selenoether
are
successfully
carried
out,
demonstrating
synthetic
utilities
present
methodology.
A
mild
and
efficient
FeCl
3
-catalyzed
oxidative
diselenylation
of
pyrrole-tethered
indoles
has
been
achieved
by
using
RSeSeR
as
the
source
selenium
m
-chloroperoxybenzoic
acid
(
CPBA)
oxidant
(yields
17–70%).
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
A
copper
hydride
(CuH)-catalyzed
regio-
and
enantioselective
hydroboration
of
1-trifluoromethylseleno
(SeCF3)-alkenes
with
H-Bpin
has
been
developed.
The
hydrocupration
an
in
situ
generated
CuH
species
is
followed
by
a
boration
reaction
to
successfully
construct
SeCF3-
Bpin-substituted
chiral
carbon
center.
key
success
the
appropriate
choice
tBu-modified
biphosphine
ligands,
which
enables
overwhelming
high
efficiency.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(8), P. 1714 - 1714
Published: April 11, 2025
Despite
the
wealth
of
data
related
to
advantages
formulating
a
wide
range
compounds
as
salts
ameliorate
their
biological
properties,
there
is
scant
information
regarding
therapeutic
potential
selenium
(Se)
salts.
In
this
work,
we
have
formulated
six
antibiotics
hydroselenite
in
order
compare
vitro
antibacterial
and
anticancer
effects
evaluate
if
approach
could
enhance
water
solubility.
regard,
almost
all
cases,
solubility
was
increased
by
one
magnitude.
All
were
screened
against
panel
three
Gram-positive
Gram-negative
bacteria.
Likewise,
antiproliferative
activity
evaluated
breast,
prostate,
glioblastoma,
pancreatic
cancer
cell
lines.
Normal
human
dermal
fibroblasts
(NHDF)
used
determine
selectivity
indexes
(SI).
Additionally,
these
novel
submitted
National
Cancer
Institute
(NCI)
study
antitumoral
potential.
Compounds
SLT-2
SLT-6
showed
potent
cytotoxicity
glioblastoma
line,
ability
induce
apoptosis
reactive
oxygen
species
(ROS)
further
assessed.
To
conclude,
demonstrated
that
formulation
several
be
feasible
obtain
biologically
active
with
an
enhanced
effect.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(19), P. 10240 - 10246
Published: Jan. 1, 2024
Herein,
we
report
a
general
and
sustainable
electrochemically
promoted
oxidative
selenocyclization
protocol
for
the
synthesis
of
organoselenyl
isoxazoles
from
2-alkyn-1-one
O
-methyloximes
diorganyl
diselenides.
ACS Medicinal Chemistry Letters,
Journal Year:
2024,
Volume and Issue:
15(9), P. 1559 - 1565
Published: Aug. 14, 2024
Carbonic
anhydrase
(CA)
inhibitors
represent
intriguing
tools
for
treating
pain.
This
study
aims
at
studying
the
pharmacological
profile
of
chalcogen
bioisosteres
aspirin,
as
CA
isoforms
(hCA
I,
II,
IV,
VII,
IX,
and
XII).
Our
results
show
that
selenoaspirin
(
