ChemistrySelect,
Journal Year:
2021,
Volume and Issue:
6(44), P. 12342 - 12345
Published: Nov. 23, 2021
Abstract
A
synthetic
method
of
polysubstituted
pyrroles
has
been
established
by
electro‐oxidative
intermolecular
annulation
easily
available
materials,
anilines
and
alkynoates.
In
an
undivided
cell,
alkynoates
aniline
converted
smoothly
into
desired
products
under
external
oxidant‐free
mild
conditions,
mechanism
verification
experiments
indicating
that
in
situ
formed
enamines
are
crucial
intermediates
for
the
transformation.
Asian Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Herein,
we
report
a
calcium‐catalyzed,
one‐pot,
four‐component
reaction
to
synthesize
diversely
substituted
pyrroles.
This
atom‐economy
involves
sequence
of
reactions
that
proceed
via
in
situ
formation
α
‐
imino
ketones,
Friedel‐Crafts
arylation,
aza‐cyclization,
and
aromatization
the
single
pot.
The
showed
broad
substrate
scope
with
good
yields.
We
demonstrated
gram‐scale
synthesis
post‐synthetic
modifications.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(18), P. 3653 - 3674
Published: Jan. 1, 2022
This
review
features
a
broad
interest
in
compiling
range
of
cascade
transformations
under
various
classifications
based
on
nature
and
reactivity
the
main
ingredient
to
solve
diverse
challenges
organic
synthesis
create
fascinating
molecules.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Herein,
we
report
an
efficient
mechanochemical
synthesis
of
α,α-amino
thioketones
involving
a
one-pot,
three-component
milling
2-oxo
aldehydes,
amines,
and
thiols.
Unlike
previous
methods,
this
protocol
does
not
require
any
catalyst
or
oxidizing
additive.
The
reaction
proceeds
through
the
thiolation
in
situ
formed
α-imino
ketones
by
liquid-assisted
grinding.
We
have
successfully
extended
to
synthesizing
benzothiazoles,
thiazoles,
quinoxalines,
demonstrating
its
efficiency
potential
field.
Importantly,
shown
gram-scale
synthesis,
synthetic
applications,
substrate
scope
protocol,
instilling
confidence
practicality.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Herein,
we
report
an
efficient
synthetic
protocol
for
the
Friedel–Crafts
reaction
of
imidazo[1,2-a]pyridines
with
propargyl
alcohols
in
HFIP.
Notably,
this
FC
allenylation
works
without
any
additional
solvent
or
catalyst
and
requires
neither
inert
conditions
nor
heating.
In
method,
HFIP,
besides
offering
hydrogen
bonding
alcohol,
also
stabilizes
resultant
carbocation,
thus
forming
product.
This
method
enables
straightforward
synthesis
1,3-enynes.
The
current
offers
a
large
substrate
diversity
good
to
excellent
yields.
We
demonstrated
gram-scale
modifications.
Asian Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Abstract
Calcium
catalysis
has
garnered
significant
attention
from
synthetic
organic
chemists
as
a
sustainable
alternative
to
Lewis
acidic
transition
metals,
rare‐earth
and
strong
Brønsted
acids.
This
alkaline
earth
metal,
abundant
in
nature,
environmentally
benign,
moisture‐tolerant,
biodegradable,
low
toxicity,
offers
distinct
advantages.
catalysts
exhibit
exceptional
proficiency
activating
diverse
functional
groups,
particularly
π‐activated
species
such
ketones,
alcohols,
enamines,
aldehydes,
alkenes,
alkynes,
allenes,
thereby
enabling
nucleophilic
additions
tandem
chemical
transformations.
These
characteristics
resonate
with
the
core
tenets
of
green
chemistry,
enhancing
atom
step
economy
while
minimizing
waste
generation.
review
presents
thorough
in‐depth
analysis
calcium‐catalyzed
multi‐component
reactions
(MCRs),
underscoring
their
transformative
role
advancing
synthesis.
Furthermore,
it
explores
untapped
potential
calcium
broadening
horizons
MCRs,
fostering
innovative
eco‐friendly
methodologies
for
applications
pharmaceuticals
materials
science.
Key
challenges
future
prospects
within
this
evolving
domain
are
also
critically
examined.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(75), P. 11050 - 11053
Published: Jan. 1, 2020
A
mild
synthetic
protocol
to
access
2-ester
pyrroles
through
Cu(OTf)2-catalysed
carbene
insertion/ester
migration/cyclization
of
enaminones
and
α-diazo
compounds
is
reported.
Synthesis,
Journal Year:
2023,
Volume and Issue:
55(08), P. 1298 - 1308
Published: Jan. 11, 2023
Abstract
A
one-pot,
four-component
strategy
for
the
synthesis
of
trifluoromethylated,
and
other
fully-substituted
pyrroles
is
reported
using
minimum
loading
calcium
catalyst
at
room
temperature.
variety
arenes,
α-keto
aldehydes,
amines,
activated
alkynes
took
part
in
reaction
to
produce
high-yielding
products.
Friedel–Crafts
arylation
aza-Michael
addition
are
key
reactions
this
approach.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(19)
Published: March 5, 2024
Abstract
We
report
here
a
catalyst‐free,
(sp
2
)C−H
imination
reaction
of
in‐situ
formed
imidazo[1,2‐
]pyridines
and
α‐iminoketones.
This
one‐pot,
multicomponent,
atom
economic
is
performed
at
moderate
to
room
temperature
without
the
need
for
any
catalyst
inert
conditions.
The
showed
good
substrate
tolerance
with
appreciable
yields.
Gram‐scale
synthesis
post‐synthetic
modifications
obtain
1,2‐diketones
are
also
described.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(22), P. 16838 - 16849
Published: Nov. 6, 2024
Herein,
we
report
an
atom-economical,
one-pot,
four-component,
diastereoselective
double-annulation
reaction
to
construct
polyfused
pyrroloquinolines.
This
highlights
the
cyclization
of
in
situ
