Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(29), P. 5845 - 5851
Published: Jan. 1, 2022
A metal-free inactive C(sp3)-H bond functionalization of thioethers with styrenes using TBHP as an initiator and DBU a base has been developed. This transformation broken through the low activity realized moderate yields. Herein extended experiments were conducted to confirm radical relay process, reaction energy intermediate transformations.
Language: Английский
Science Bulletin, Journal Year: 2021, Volume and Issue: 66(23), P. 2412 - 2429
Published: July 13, 2021
Language: Английский
Citations
293
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(19), P. 11269 - 11335
Published: Sept. 26, 2023
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or diversification of novel molecular entities with improved physicochemical biological activities. LSF can thus greatly accelerate development medicinally relevant compounds, crop protecting agents, and functional materials. Electrochemical synthesis has emerged as an environmentally friendly platform transformation organic compounds. Over past decade, electrochemical late-stage (eLSF) gained major momentum, which is summarized herein up to February 2023.
Language: Английский
Citations
141
Advanced Energy Materials, Journal Year: 2024, Volume and Issue: 14(28)
Published: Feb. 21, 2024
Abstract Electrocatalytic C−N couplings are promising alternatives to construct bonds and synthesize vital chemicals, including amine, amide, amino acid, oxime, imine, nitrile, under ambient conditions. In recent years, the electrocatalytic coupling has attracted a wide range of research interest achieved considerable developments. Here, is systematically reviewed aiming at reductive cathode oxidative anode. cathodic part, reaction systems, corresponding design principles electrocatalysts for different mechanism studies from experimental theoretical aspects, application‐oriented devices summarized. Anodic offers potential approach replace conventional energy‐demand synthesis protocols, an indispensable part green controllable construction unsaturated C = N C≡N bonds. According principle that electron transfer crucial point in anodic coupling, reactions sorted out based on direct indirect paths, respectively. Finally, challenges outlooks this field proposed. appealing topic electrochemistry possesses infinite possibilities future.
Language: Английский
Citations
21
Science Advances, Journal Year: 2024, Volume and Issue: 10(3)
Published: Jan. 17, 2024
Data science is assuming a pivotal role in guiding reaction optimization and streamlining experimental workloads the evolving landscape of synthetic chemistry. A discipline-wide goal development workflows that integrate computational chemistry data tools with high-throughput experimentation as it provides experimentalists ability to maximize success expensive campaigns. Here, we report an end-to-end data-driven process effectively predict how structural features coupling partners ligands affect Cu-catalyzed C–N reactions. The established workflow underscores limitations posed by substrates while also providing systematic ligand prediction tool uses probability assess when will be successful. This platform strategically designed confront intrinsic unpredictability frequently encountered deployment.
Language: Английский
Citations
19
Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(12), P. 6419 - 6424
Published: Jan. 20, 2021
Abstract Electrooxidative annulations involving mild transition metal‐catalyzed C−H activation have emerged as a transformative strategy for the rapid construction of five‐ and six‐membered heterocycles. In contrast, we herein describe first electrochemical [5+2] cycloadditions to assemble valuable seven‐membered benzoxepine skeletons by C−H/O−H activation. The efficient alkyne annulation featured ample substrate scope, using electricity only oxidant. Mechanistic studies provided strong support rhodium(III/I) regime, benzoxepine‐coordinated rhodium(I) sandwich complex catalyst resting state, which was re‐oxidized rhodium(III) anodic oxidation.
Language: Английский
Citations
74
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(8), P. 2256 - 2279
Published: Jan. 1, 2022
In this review article, we summarized recent advances in the transition metal-catalyzed heteroannulative difunctionalization of alkenes via direct C–H activation to access heterocyclic frameworks.
Language: Английский
Citations
57
Green Chemistry, Journal Year: 2023, Volume and Issue: 25(9), P. 3606 - 3614
Published: Jan. 1, 2023
We describe a cobalta-electro-catalyzed enantioselective C–H annulation of arylphosphinamides with alkynes for P-stereogenic compounds via desymmetrization and kinetic resolution processes.
Language: Английский
Citations
40
Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 442, P. 213986 - 213986
Published: May 13, 2021
Language: Английский
Citations
44
Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(7), P. 1319 - 1325
Published: Feb. 23, 2022
Abstract An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety polycyclic quinazolinones were successfully synthesized in 52–81% yields under transition metal‐ oxidant‐free conditions. The used this strategy possesses the advantages bench‐stablity, cost‐effectivity high‐efficiency. Additionally, gram‐scale reaction, broad substrate scope good functional group tolerance demonstrated synthetic usefulness protocol. magnified image
Language: Английский
Citations
36
Green Chemistry, Journal Year: 2022, Volume and Issue: 24(3), P. 1342 - 1349
Published: Jan. 1, 2022
Electrocatalysis for the controllable coupling of thiols with DCE was achieved to generate value-added β-chloro-tethered sulfur compounds in batch and flow.
Language: Английский
Citations
30